Publication
The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series
| Summary: | To highlight the effect of salt precursors on the final properties, bioactivity and biocompatibility, five quaternary (Si–Ca–P–Na) glass compositions were successfully prepared through two distinct rapid sol–gel routes; one using acetate salt precursors (A) catalysed by nitric acid, and the other using nitrate salts (N) and citric acid as a catalyst. The sols dried rapidly, and stabilised at 550 & 800 °C to be characterised by X–ray diffraction (XRD), Magic angle spinning–Nuclear magnetic resonance (29Si MAS–NMR) and Fourier transform infra–red spectroscopy (FTIR). Upon immersion in simulated body fluid (SBF), hydroxyapatite (HAp) formation was initially enhanced by increasing Ca–content up to 40 mol%, but the formation of calcite was favoured with further increments of Ca to 45 and 48 mol%. The A–glasses exhibited lower density and lower network connectivity compared with N–glasses. The chemical surface modifications after 4 h in SBF were more evident for N–glasses in comparison to A–glasses. The biocompatibility is favoured for the samples treated at 800 °C and for the samples of the higher silica contents. |
|---|---|
| Main Authors: | Ben-Arfa, Basam A.E. |
| Other Authors: | Palamá, Ilaria E.; Miranda Salvado, Isabel M.; Ferreira, José M.F.; Pullar, Robert C. |
| Subject: | Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| Year: | 2020 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade de Aveiro |
| Language: | English |
| Origin: | RIA - Repositório Institucional da Universidade de Aveiro |
| _version_ | 1868442943852904448 |
|---|---|
| author | Ben-Arfa, Basam A.E. |
| author2 | Palamá, Ilaria E. Miranda Salvado, Isabel M. Ferreira, José M.F. Pullar, Robert C. |
| author2_role | author author author author |
| author_facet | Ben-Arfa, Basam A.E. Palamá, Ilaria E. Miranda Salvado, Isabel M. Ferreira, José M.F. Pullar, Robert C. |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ben-Arfa, Basam A.E.\"},{\"Person.name\":\"Palamá, Ilaria E.\"},{\"Person.name\":\"Miranda Salvado, Isabel M.\"},{\"Person.name\":\"Ferreira, José M.F.\"},{\"Person.name\":\"Pullar, Robert C.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Ben-Arfa, Basam A.E. Palamá, Ilaria E. Miranda Salvado, Isabel M. Ferreira, José M.F. Pullar, Robert C. |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-05-08T08:37:57Z |
| datacite.date.embargoed.fl_str_mv | 2023-05-08T08:37:57Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| datacite.titles.title.fl_str_mv | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| dc.creator.none.fl_str_mv | Ben-Arfa, Basam A.E. Palamá, Ilaria E. Miranda Salvado, Isabel M. Ferreira, José M.F. Pullar, Robert C. |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-05-08T08:37:57Z |
| dc.date.embargoed.fl_str_mv | 2023-05-08T08:37:57Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10773/37560 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| dc.title.fl_str_mv | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | To highlight the effect of salt precursors on the final properties, bioactivity and biocompatibility, five quaternary (Si–Ca–P–Na) glass compositions were successfully prepared through two distinct rapid sol–gel routes; one using acetate salt precursors (A) catalysed by nitric acid, and the other using nitrate salts (N) and citric acid as a catalyst. The sols dried rapidly, and stabilised at 550 & 800 °C to be characterised by X–ray diffraction (XRD), Magic angle spinning–Nuclear magnetic resonance (29Si MAS–NMR) and Fourier transform infra–red spectroscopy (FTIR). Upon immersion in simulated body fluid (SBF), hydroxyapatite (HAp) formation was initially enhanced by increasing Ca–content up to 40 mol%, but the formation of calcite was favoured with further increments of Ca to 45 and 48 mol%. The A–glasses exhibited lower density and lower network connectivity compared with N–glasses. The chemical surface modifications after 4 h in SBF were more evident for N–glasses in comparison to A–glasses. The biocompatibility is favoured for the samples treated at 800 °C and for the samples of the higher silica contents. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ria_4dffdd9720c5f3ccd85b4e7c8f9bc5cf |
| identifier.url.fl_str_mv | http://hdl.handle.net/10773/37560 |
| instacron_str | ua |
| institution | Universidade de Aveiro |
| instname_str | Universidade de Aveiro |
| language | eng |
| network_acronym_str | ria |
| network_name_str | RIA - Repositório Institucional da Universidade de Aveiro |
| oai_identifier_str | oai:ria.ua.pt:10773/37560 |
| organization_str_mv | urn:organizationAcronym:ua |
| person_str_mv | Ben-Arfa, Basam A.E. Palamá, Ilaria E. Miranda Salvado, Isabel M. Ferreira, José M.F. Pullar, Robert C. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RIA - Repositório Institucional da Universidade de Aveiro |
| repository_id_str | urn:repositoryAcronym:ria |
| service_str_mv | urn:repositoryAcronym:ria |
| spelling | pt_PTTo highlight the effect of salt precursors on the final properties, bioactivity and biocompatibility, five quaternary (Si–Ca–P–Na) glass compositions were successfully prepared through two distinct rapid sol–gel routes; one using acetate salt precursors (A) catalysed by nitric acid, and the other using nitrate salts (N) and citric acid as a catalyst. The sols dried rapidly, and stabilised at 550 & 800 °C to be characterised by X–ray diffraction (XRD), Magic angle spinning–Nuclear magnetic resonance (29Si MAS–NMR) and Fourier transform infra–red spectroscopy (FTIR). Upon immersion in simulated body fluid (SBF), hydroxyapatite (HAp) formation was initially enhanced by increasing Ca–content up to 40 mol%, but the formation of calcite was favoured with further increments of Ca to 45 and 48 mol%. The A–glasses exhibited lower density and lower network connectivity compared with N–glasses. The chemical surface modifications after 4 h in SBF were more evident for N–glasses in comparison to A–glasses. The biocompatibility is favoured for the samples treated at 800 °C and for the samples of the higher silica contents.application/pdfengElsevierpt_PTThe role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass seriesBen-Arfa, Basam A.E.Palamá, Ilaria E.Miranda Salvado, Isabel M.Ferreira, José M.F.Pullar, Robert C.Handlehttp://hdl.handle.net/10773/37560ISSNIsPartOf0272-8842DOIIsPartOf10.1016/j.ceramint.2019.09.0732023-05-08T08:37:57Z2020-01-01T00:00:00Z2020-01http://purl.org/coar/access_right/c_abf2open accesspt_PTBioactive glassespt_PTBiocompatibilitypt_PTCa/P ratiopt_PTHigh silica contentpt_PTSol-gel derived glasspt_PTIn vitro MTT tests16805478 byteshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://ria.ua.pt/bitstream/10773/37560/1/The%20role%20of%20calcium%20%28source%20%26%20content%29%20on%20the%20in%20vitro%20behaviour%20of%20sol%e2%80%93gel.pdfliteraturehttp://purl.org/coar/resource_type/c_6501journal article |
| spellingShingle | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series Ben-Arfa, Basam A.E. Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| status | SINGLETON |
| subject.fl_str_mv | Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| title | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| title_full | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| title_fullStr | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| title_full_unstemmed | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| title_short | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| title_sort | The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series |
| topic | Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| topic_facet | Bioactive glasses Biocompatibility Ca/P ratio High silica content Sol-gel derived glass In vitro MTT tests |
| url | http://hdl.handle.net/10773/37560 |
| visible | 1 |