Publicação
Tetracationic porphyrin derivatives against human breast cancer
| Resumo: | Photodynamic therapy (PDT) is an approved therapeutic approach and an alternative to conventional chemotherapy for the treatment of several types of cancer with the advantages of reducing the side effects and developing resistance mechanisms. Here, was evaluated the photosensitization capabilities of 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin (3), its N-confused isomer (4) and of the neutral precursors (1) and (2) and the results were compared with the ones obtained with the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP). Both regular porphyrin derivatives 1 and 3 showed higher efficiency to generate singlet oxygen than TMPyP. The PDT assays towards MCF-7 cells under red light irradiation (λ > 640 nm, 23.7 mW cm-2) demonstrated that the cationic porphyrin 3 is an efficient photosensitizer to kill MCF-7 breast cancer cells. The study of the cell death mechanisms induced by the photodynamic process showed that the studied porphyrin 3 and TMPyP caused cell death by autophagic flux and necrosis. |
|---|---|
| Autores principais: | Gamelas, Sara R. D. |
| Outros Autores: | Moura, Nuno M. M.; Habraken, Yvette; Piette, Jacques; Neves, Maria G. P. M. S.; Faustino, Maria A. F. |
| Assunto: | Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Aveiro |
| Idioma: | inglês |
| Origem: | RIA - Repositório Institucional da Universidade de Aveiro |
| _version_ | 1866173135713206272 |
|---|---|
| author | Gamelas, Sara R. D. |
| author2 | Moura, Nuno M. M. Habraken, Yvette Piette, Jacques Neves, Maria G. P. M. S. Faustino, Maria A. F. |
| author2_role | author author author author author |
| author_facet | Gamelas, Sara R. D. Moura, Nuno M. M. Habraken, Yvette Piette, Jacques Neves, Maria G. P. M. S. Faustino, Maria A. F. |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gamelas, Sara R. D.\"},{\"Person.name\":\"Moura, Nuno M. M.\"},{\"Person.name\":\"Habraken, Yvette\"},{\"Person.name\":\"Piette, Jacques\"},{\"Person.name\":\"Neves, Maria G. P. M. S.\"},{\"Person.name\":\"Faustino, Maria A. F.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Gamelas, Sara R. D. Moura, Nuno M. M. Habraken, Yvette Piette, Jacques Neves, Maria G. P. M. S. Faustino, Maria A. F. |
| datacite.date.Accepted.fl_str_mv | 2021-09-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-06-13T10:45:09Z |
| datacite.date.embargoed.fl_str_mv | 2025-06-13T10:45:09Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| datacite.titles.title.fl_str_mv | Tetracationic porphyrin derivatives against human breast cancer |
| dc.creator.none.fl_str_mv | Gamelas, Sara R. D. Moura, Nuno M. M. Habraken, Yvette Piette, Jacques Neves, Maria G. P. M. S. Faustino, Maria A. F. |
| dc.date.Accepted.fl_str_mv | 2021-09-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-06-13T10:45:09Z |
| dc.date.embargoed.fl_str_mv | 2025-06-13T10:45:09Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10773/37544 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| dc.title.fl_str_mv | Tetracationic porphyrin derivatives against human breast cancer |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Photodynamic therapy (PDT) is an approved therapeutic approach and an alternative to conventional chemotherapy for the treatment of several types of cancer with the advantages of reducing the side effects and developing resistance mechanisms. Here, was evaluated the photosensitization capabilities of 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin (3), its N-confused isomer (4) and of the neutral precursors (1) and (2) and the results were compared with the ones obtained with the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP). Both regular porphyrin derivatives 1 and 3 showed higher efficiency to generate singlet oxygen than TMPyP. The PDT assays towards MCF-7 cells under red light irradiation (λ > 640 nm, 23.7 mW cm-2) demonstrated that the cationic porphyrin 3 is an efficient photosensitizer to kill MCF-7 breast cancer cells. The study of the cell death mechanisms induced by the photodynamic process showed that the studied porphyrin 3 and TMPyP caused cell death by autophagic flux and necrosis. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ria_9e07a95b0c817cbd2b00a1c0f243bb98 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10773/37544 |
| instacron_str | ua |
| institution | Universidade de Aveiro |
| instname_str | Universidade de Aveiro |
| language | eng |
| network_acronym_str | ria |
| network_name_str | RIA - Repositório Institucional da Universidade de Aveiro |
| oai_identifier_str | oai:ria.ua.pt:10773/37544 |
| organization_str_mv | urn:organizationAcronym:ua |
| person_str_mv | Gamelas, Sara R. D. Moura, Nuno M. M. Habraken, Yvette Piette, Jacques Neves, Maria G. P. M. S. Faustino, Maria A. F. |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RIA - Repositório Institucional da Universidade de Aveiro |
| repository_id_str | urn:repositoryAcronym:ria |
| service_str_mv | urn:repositoryAcronym:ria |
| spelling | pt_PTPhotodynamic therapy (PDT) is an approved therapeutic approach and an alternative to conventional chemotherapy for the treatment of several types of cancer with the advantages of reducing the side effects and developing resistance mechanisms. Here, was evaluated the photosensitization capabilities of 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin (3), its N-confused isomer (4) and of the neutral precursors (1) and (2) and the results were compared with the ones obtained with the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP). Both regular porphyrin derivatives 1 and 3 showed higher efficiency to generate singlet oxygen than TMPyP. The PDT assays towards MCF-7 cells under red light irradiation (λ > 640 nm, 23.7 mW cm-2) demonstrated that the cationic porphyrin 3 is an efficient photosensitizer to kill MCF-7 breast cancer cells. The study of the cell death mechanisms induced by the photodynamic process showed that the studied porphyrin 3 and TMPyP caused cell death by autophagic flux and necrosis.application/pdfengElsevierpt_PTTetracationic porphyrin derivatives against human breast cancerGamelas, Sara R. D.Moura, Nuno M. M.Habraken, YvettePiette, JacquesNeves, Maria G. P. M. S.Faustino, Maria A. F.Handlehttp://hdl.handle.net/10773/37544ISSNIsPartOf1011-1344DOIIsPartOf10.1016/j.jphotobiol.2021.1122582025-06-13T10:45:09Z2021-09-01T00:00:00Z2021-09http://purl.org/coar/access_right/c_abf2open accesspt_PTPorphyrinpt_PTPhotodynamic therapypt_PTPhotosensitizerpt_PTCancerpt_PTMCF-7 cells1897743 byteshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://ria.ua.pt/bitstream/10773/37544/1/Tetracationic%20porphyrin%20derivatives%20against%20human%20breast%20cancer.pdfliteraturehttp://purl.org/coar/resource_type/c_6501journal article |
| spellingShingle | Tetracationic porphyrin derivatives against human breast cancer Gamelas, Sara R. D. Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| status | SINGLETON |
| subject.fl_str_mv | Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| title | Tetracationic porphyrin derivatives against human breast cancer |
| title_full | Tetracationic porphyrin derivatives against human breast cancer |
| title_fullStr | Tetracationic porphyrin derivatives against human breast cancer |
| title_full_unstemmed | Tetracationic porphyrin derivatives against human breast cancer |
| title_short | Tetracationic porphyrin derivatives against human breast cancer |
| title_sort | Tetracationic porphyrin derivatives against human breast cancer |
| topic | Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| topic_facet | Porphyrin Photodynamic therapy Photosensitizer Cancer MCF-7 cells |
| url | http://hdl.handle.net/10773/37544 |
| visible | 1 |