Publication
Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease
| Summary: | Objectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. The type of fat intake was evaluated, and the interaction between SNPs and dietary fat in modulating disease activity was analyzed. Results - Individuals who were homozygous for the IL6-174G/C polymorphism had a six-fold higher risk for CD (odds ratio (OR)=6.1; 95% confidence interval (95% CI)=1.9-19.4), whereas the TT genotype on the TNFalpha-857C/T polymorphism was associated with more active disease (OR=10.4; 95% CI=1.1-94.1). A high intake of total, saturated, and monounsaturated fats, as well as a higher ratio of n-6/n-3 polyunsaturated fatty acid (PUFA), was associated with a more active phenotype (P<0.05). Furthermore, there was an interaction between dietary fat intake and SNPs, with a high intake of saturated and monounsaturated fats being associated with active disease, mainly in patients carrying the variant alleles of the 857 TNFalpha polymorphism (OR=6.0, 95% CI=1.4-26.2; OR=5.17; 95% CI=1.4-19.2, respectively) and the 174 IL6 polymorphism (OR=2.95; 95% CI=1.0-9.1; OR=3.21; 95% CI=1.0-10.4, respectively). Finally, low intake of n-3 PUFA and high n-6/n-3 PUFA ratio in patients with the TNFalpha 857 polymorphism were associated with higher disease activity (OR=3.6; 95% CI=1.0-13.0; OR=5.92; 95% CI=1.3-26.5, respectively). Conclusions - These results show that different types of fat may interact with cytokine genotype, modulating disease activity. |
|---|---|
| Main Authors: | Guerreiro, Catarina Sousa |
| Other Authors: | Ferreira, Paula; Tavares, Lourdes; Santos, Paula Moura dos; Neves, Manuela; Brito, Miguel; Cravo, Marília |
| Subject: | Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| Year: | 2009 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Instituto Politécnico de Lisboa |
| Language: | English |
| Origin: | Repositório Científico do Instituto Politécnico de Lisboa |
| _version_ | 1866887300552589312 |
|---|---|
| author | Guerreiro, Catarina Sousa |
| author2 | Ferreira, Paula Tavares, Lourdes Santos, Paula Moura dos Neves, Manuela Brito, Miguel Cravo, Marília |
| author2_role | author author author author author author |
| author_facet | Guerreiro, Catarina Sousa Ferreira, Paula Tavares, Lourdes Santos, Paula Moura dos Neves, Manuela Brito, Miguel Cravo, Marília |
| author_role | author |
| contributor_name_str_mv | RCIPL |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Guerreiro, Catarina Sousa\"},{\"Person.name\":\"Ferreira, Paula\"},{\"Person.name\":\"Tavares, Lourdes\"},{\"Person.name\":\"Santos, Paula Moura dos\"},{\"Person.name\":\"Neves, Manuela\"},{\"Person.name\":\"Brito, Miguel\",\"Person.identifier.orcid\":\"0000-0001-6394-658X\"},{\"Person.name\":\"Cravo, Marília\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RCIPL |
| datacite.creators.creator.creatorName.fl_str_mv | Guerreiro, Catarina Sousa Ferreira, Paula Tavares, Lourdes Santos, Paula Moura dos Neves, Manuela Brito, Miguel Cravo, Marília |
| datacite.date.Accepted.fl_str_mv | 2009-09-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-01-02T16:18:25Z |
| datacite.date.embargoed.fl_str_mv | 2014-01-02T16:18:25Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| datacite.titles.title.fl_str_mv | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| dc.contributor.none.fl_str_mv | RCIPL |
| dc.creator.none.fl_str_mv | Guerreiro, Catarina Sousa Ferreira, Paula Tavares, Lourdes Santos, Paula Moura dos Neves, Manuela Brito, Miguel Cravo, Marília |
| dc.date.Accepted.fl_str_mv | 2009-09-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-01-02T16:18:25Z |
| dc.date.embargoed.fl_str_mv | 2014-01-02T16:18:25Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.21/3052 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Nature |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| dc.title.fl_str_mv | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Objectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. The type of fat intake was evaluated, and the interaction between SNPs and dietary fat in modulating disease activity was analyzed. Results - Individuals who were homozygous for the IL6-174G/C polymorphism had a six-fold higher risk for CD (odds ratio (OR)=6.1; 95% confidence interval (95% CI)=1.9-19.4), whereas the TT genotype on the TNFalpha-857C/T polymorphism was associated with more active disease (OR=10.4; 95% CI=1.1-94.1). A high intake of total, saturated, and monounsaturated fats, as well as a higher ratio of n-6/n-3 polyunsaturated fatty acid (PUFA), was associated with a more active phenotype (P<0.05). Furthermore, there was an interaction between dietary fat intake and SNPs, with a high intake of saturated and monounsaturated fats being associated with active disease, mainly in patients carrying the variant alleles of the 857 TNFalpha polymorphism (OR=6.0, 95% CI=1.4-26.2; OR=5.17; 95% CI=1.4-19.2, respectively) and the 174 IL6 polymorphism (OR=2.95; 95% CI=1.0-9.1; OR=3.21; 95% CI=1.0-10.4, respectively). Finally, low intake of n-3 PUFA and high n-6/n-3 PUFA ratio in patients with the TNFalpha 857 polymorphism were associated with higher disease activity (OR=3.6; 95% CI=1.0-13.0; OR=5.92; 95% CI=1.3-26.5, respectively). Conclusions - These results show that different types of fat may interact with cytokine genotype, modulating disease activity. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ipl.pt/bitstreams/40923961-2ebd-4dde-945c-b5dd4c7b0926/download |
| id | ripl_9ad71cb2fa2c126fcfddca2ec9ecb756 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.21/3052 |
| instacron_str | ipl |
| institution | Instituto Politécnico de Lisboa |
| instname_str | Instituto Politécnico de Lisboa |
| language | eng |
| network_acronym_str | ripl |
| network_name_str | Repositório Científico do Instituto Politécnico de Lisboa |
| oai_identifier_str | oai:repositorio.ipl.pt:10400.21/3052 |
| organization_str_mv | urn:organizationAcronym:ipl |
| person_str_mv | Guerreiro, Catarina Sousa Ferreira, Paula Tavares, Lourdes Santos, Paula Moura dos Neves, Manuela Brito, Miguel Brito, Miguel https://www.ciencia-id.pt/231F-F341-7E93 231F-F341-7E93 http://orcid.org/0000-0001-6394-658X 0000-0001-6394-658X Cravo, Marília |
| publishDate | 2009 |
| publisher.none.fl_str_mv | Nature |
| reponame_str | Repositório Científico do Instituto Politécnico de Lisboa |
| repository_id_str | urn:repositoryAcronym:ripl |
| service_str_mv | urn:repositoryAcronym:ripl |
| spelling | engNatureporObjectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. The type of fat intake was evaluated, and the interaction between SNPs and dietary fat in modulating disease activity was analyzed. Results - Individuals who were homozygous for the IL6-174G/C polymorphism had a six-fold higher risk for CD (odds ratio (OR)=6.1; 95% confidence interval (95% CI)=1.9-19.4), whereas the TT genotype on the TNFalpha-857C/T polymorphism was associated with more active disease (OR=10.4; 95% CI=1.1-94.1). A high intake of total, saturated, and monounsaturated fats, as well as a higher ratio of n-6/n-3 polyunsaturated fatty acid (PUFA), was associated with a more active phenotype (P<0.05). Furthermore, there was an interaction between dietary fat intake and SNPs, with a high intake of saturated and monounsaturated fats being associated with active disease, mainly in patients carrying the variant alleles of the 857 TNFalpha polymorphism (OR=6.0, 95% CI=1.4-26.2; OR=5.17; 95% CI=1.4-19.2, respectively) and the 174 IL6 polymorphism (OR=2.95; 95% CI=1.0-9.1; OR=3.21; 95% CI=1.0-10.4, respectively). Finally, low intake of n-3 PUFA and high n-6/n-3 PUFA ratio in patients with the TNFalpha 857 polymorphism were associated with higher disease activity (OR=3.6; 95% CI=1.0-13.0; OR=5.92; 95% CI=1.3-26.5, respectively). Conclusions - These results show that different types of fat may interact with cytokine genotype, modulating disease activity.application/pdfporFatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's diseaseGuerreiro, Catarina SousaFerreira, PaulaTavares, LourdesSantos, Paula Moura dosNeves, ManuelaPersonalBrito, MiguelDSpacehttp://dspace.org/items/4252d8e0-800c-4d67-8b13-0b711d860669DSpacehttp://dspace.org/items/4252d8e0-800c-4d67-8b13-0b711d860669BritoMiguelCiência IDhttps://www.ciencia-id.pt231F-F341-7E93ORCIDhttp://orcid.org0000-0001-6394-658XResearcher IDhttps://www.researcherid.comA-7970-2016Scopus Author IDhttps://www.scopus.com35224551000Scopus Author IDhttps://www.scopus.com57200288349Cravo, MaríliaHostingInstitutionOrganizationalRCIPLe-mailmailto:rcaap@sp.ipl.ptrcaap@sp.ipl.ptISSNIsPartOf1572-02412014-01-02T16:18:25Z2009-092009-09-01T00:00:00ZHandlehttp://hdl.handle.net/10400.21/3052http://purl.org/coar/access_right/c_abf2open accessCrohn diseaseCytokinesDietary fatsFatty acidsGenetic predisposition to diseaseInterleukin-6NutrigenomicsPolymorphism, Single nucleotideRisk factorTumor necrosis factor-alpha257867 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ipl.pt/bitstreams/40923961-2ebd-4dde-945c-b5dd4c7b0926/downloadAmerican Journal of Gastroenterology10422412249 |
| spellingShingle | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease Guerreiro, Catarina Sousa Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| status | SINGLETON |
| subject.fl_str_mv | Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| title | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| title_full | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| title_fullStr | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| title_full_unstemmed | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| title_short | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| title_sort | Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease |
| topic | Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| topic_facet | Crohn disease Cytokines Dietary fats Fatty acids Genetic predisposition to disease Interleukin-6 Nutrigenomics Polymorphism, Single nucleotide Risk factor Tumor necrosis factor-alpha |
| url | http://hdl.handle.net/10400.21/3052 |
| visible | 1 |