Publicação
Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities
| Resumo: | Introduction: Honey is used in various cultures as a traditional medicine and folkloric treatment. The aim of this study was to determine the antioxidant and the anti-inflammatory activities of 31 Algerian honeys and acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities of phenolic compounds extracts of these honeys. Methods: The anti-inflammatory activity of honey was evaluated by the method of inhibition of BSA (Bovin Serum Albumin) heat-induced denaturation. The inhibition of AChE and alpha-glucosidase by the honey extracts was evaluated by in-vitro methods. Results: The highest percentage of inhibition (85.33%) of BSA denaturation was obtained with polyfloral honey (H27). Radical scavenging activity of honey samples against 1,1-diphenyl-2-picrilhydrazyl (DPPH), and 2,2'-azinobis(-3) -ethylbenzothiazoline-6-sulfonic acid (ABTS) varied from 4.41 to 83.93% and from 2.52 to 63.24%, respectively. AChE inhibitory activity is one target to prevent neurodegenerative damage in Alzheimer's disease. AChE inhibition recorded values from 20.69 to 76.04%. alpha-glucosidase inhibitors such as acarbose is preconized for the control of hyperglycemia and prevent diabetes damages. Honey extracts demonstrated a significant inhibitory effect on alpha-glucosidase activity. Moreover, the effect of Fabacece honey (H19) (IC50 = 52.20 mu g/mL) was found to be more potent than acarbose (IC50 = 204.27 mu g/mL). Correlations were observed between antioxidants and anti-inflammatory activities, AChE and alpha-glucosidase inhibitions with total phenolic compounds and flavonoids content in honey samples. Conclusion: This study showed that honey could be exploited as a potential antioxidant and anti-inflammatory agent within therapeutic medicine. |
|---|---|
| Autores principais: | Zaidi, Hicham |
| Outros Autores: | Ouchemoukh, Salim; Amessis-Ouchemoukh, Nadia; DEBBACHE-BENAIDA, NADJET; Pacheco, Rita; Serralheiro, Maria Luisa; Araujo, Maria Eduarda |
| Assunto: | Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Instituto Politécnico de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Científico do Instituto Politécnico de Lisboa |
| _version_ | 1863852906231365632 |
|---|---|
| author | Zaidi, Hicham |
| author2 | Ouchemoukh, Salim Amessis-Ouchemoukh, Nadia DEBBACHE-BENAIDA, NADJET Pacheco, Rita Serralheiro, Maria Luisa Araujo, Maria Eduarda |
| author2_role | author author author author author author |
| author_facet | Zaidi, Hicham Ouchemoukh, Salim Amessis-Ouchemoukh, Nadia DEBBACHE-BENAIDA, NADJET Pacheco, Rita Serralheiro, Maria Luisa Araujo, Maria Eduarda |
| author_role | author |
| contributor_name_str_mv | RCIPL |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Zaidi, Hicham\"},{\"Person.name\":\"Ouchemoukh, Salim\"},{\"Person.name\":\"Amessis-Ouchemoukh, Nadia\"},{\"Person.name\":\"DEBBACHE-BENAIDA, NADJET\",\"Person.identifier.orcid\":\"0000-0003-1561-7305\"},{\"Person.name\":\"Pacheco, Rita\",\"Person.identifier.orcid\":\"0000-0001-5192-3006\"},{\"Person.name\":\"Serralheiro, Maria Luisa\",\"Person.identifier.orcid\":\"0000-0001-7541-9613\"},{\"Person.name\":\"Araujo, Maria Eduarda\",\"Person.identifier.orcid\":\"0000-0002-9876-9015\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RCIPL |
| datacite.creators.creator.creatorName.fl_str_mv | Zaidi, Hicham Ouchemoukh, Salim Amessis-Ouchemoukh, Nadia DEBBACHE-BENAIDA, NADJET Pacheco, Rita Serralheiro, Maria Luisa Araujo, Maria Eduarda |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-02-08T14:37:06Z |
| datacite.date.embargoed.fl_str_mv | 2019-02-08T14:37:06Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| datacite.titles.title.fl_str_mv | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| dc.contributor.none.fl_str_mv | RCIPL |
| dc.creator.none.fl_str_mv | Zaidi, Hicham Ouchemoukh, Salim Amessis-Ouchemoukh, Nadia DEBBACHE-BENAIDA, NADJET Pacheco, Rita Serralheiro, Maria Luisa Araujo, Maria Eduarda |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-02-08T14:37:06Z |
| dc.date.embargoed.fl_str_mv | 2019-02-08T14:37:06Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.21/9474 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| dc.title.fl_str_mv | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: Honey is used in various cultures as a traditional medicine and folkloric treatment. The aim of this study was to determine the antioxidant and the anti-inflammatory activities of 31 Algerian honeys and acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities of phenolic compounds extracts of these honeys. Methods: The anti-inflammatory activity of honey was evaluated by the method of inhibition of BSA (Bovin Serum Albumin) heat-induced denaturation. The inhibition of AChE and alpha-glucosidase by the honey extracts was evaluated by in-vitro methods. Results: The highest percentage of inhibition (85.33%) of BSA denaturation was obtained with polyfloral honey (H27). Radical scavenging activity of honey samples against 1,1-diphenyl-2-picrilhydrazyl (DPPH), and 2,2'-azinobis(-3) -ethylbenzothiazoline-6-sulfonic acid (ABTS) varied from 4.41 to 83.93% and from 2.52 to 63.24%, respectively. AChE inhibitory activity is one target to prevent neurodegenerative damage in Alzheimer's disease. AChE inhibition recorded values from 20.69 to 76.04%. alpha-glucosidase inhibitors such as acarbose is preconized for the control of hyperglycemia and prevent diabetes damages. Honey extracts demonstrated a significant inhibitory effect on alpha-glucosidase activity. Moreover, the effect of Fabacece honey (H19) (IC50 = 52.20 mu g/mL) was found to be more potent than acarbose (IC50 = 204.27 mu g/mL). Correlations were observed between antioxidants and anti-inflammatory activities, AChE and alpha-glucosidase inhibitions with total phenolic compounds and flavonoids content in honey samples. Conclusion: This study showed that honey could be exploited as a potential antioxidant and anti-inflammatory agent within therapeutic medicine. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ipl.pt/bitstreams/47026846-410f-4261-bfab-e5c6f6391b14/download |
| id | ripl_f1d2777bcfe2f654c19cff366b005224 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.21/9474 |
| instacron_str | ipl |
| institution | Instituto Politécnico de Lisboa |
| instname_str | Instituto Politécnico de Lisboa |
| language | eng |
| network_acronym_str | ripl |
| network_name_str | Repositório Científico do Instituto Politécnico de Lisboa |
| oai_identifier_str | oai:repositorio.ipl.pt:10400.21/9474 |
| organization_str_mv | urn:organizationAcronym:ipl |
| person_str_mv | Zaidi, Hicham Ouchemoukh, Salim Amessis-Ouchemoukh, Nadia DEBBACHE-BENAIDA, NADJET DEBBACHE-BENAIDA, NADJET http://orcid.org/0000-0003-1561-7305 0000-0003-1561-7305 Pacheco, Rita Pacheco, Rita https://www.ciencia-id.pt/9F13-D310-B5A3 9F13-D310-B5A3 http://orcid.org/0000-0001-5192-3006 0000-0001-5192-3006 Serralheiro, Maria Luisa Serralheiro, Maria Luisa http://orcid.org/0000-0001-7541-9613 0000-0001-7541-9613 Araujo, Maria Eduarda Araujo, Maria Eduarda http://orcid.org/0000-0002-9876-9015 0000-0002-9876-9015 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório Científico do Instituto Politécnico de Lisboa |
| repository_id_str | urn:repositoryAcronym:ripl |
| service_str_mv | urn:repositoryAcronym:ripl |
| spelling | engElsevierpt_PTIntroduction: Honey is used in various cultures as a traditional medicine and folkloric treatment. The aim of this study was to determine the antioxidant and the anti-inflammatory activities of 31 Algerian honeys and acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities of phenolic compounds extracts of these honeys. Methods: The anti-inflammatory activity of honey was evaluated by the method of inhibition of BSA (Bovin Serum Albumin) heat-induced denaturation. The inhibition of AChE and alpha-glucosidase by the honey extracts was evaluated by in-vitro methods. Results: The highest percentage of inhibition (85.33%) of BSA denaturation was obtained with polyfloral honey (H27). Radical scavenging activity of honey samples against 1,1-diphenyl-2-picrilhydrazyl (DPPH), and 2,2'-azinobis(-3) -ethylbenzothiazoline-6-sulfonic acid (ABTS) varied from 4.41 to 83.93% and from 2.52 to 63.24%, respectively. AChE inhibitory activity is one target to prevent neurodegenerative damage in Alzheimer's disease. AChE inhibition recorded values from 20.69 to 76.04%. alpha-glucosidase inhibitors such as acarbose is preconized for the control of hyperglycemia and prevent diabetes damages. Honey extracts demonstrated a significant inhibitory effect on alpha-glucosidase activity. Moreover, the effect of Fabacece honey (H19) (IC50 = 52.20 mu g/mL) was found to be more potent than acarbose (IC50 = 204.27 mu g/mL). Correlations were observed between antioxidants and anti-inflammatory activities, AChE and alpha-glucosidase inhibitions with total phenolic compounds and flavonoids content in honey samples. Conclusion: This study showed that honey could be exploited as a potential antioxidant and anti-inflammatory agent within therapeutic medicine.application/pdfpt_PTBiological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activitiesZaidi, HichamOuchemoukh, SalimAmessis-Ouchemoukh, NadiaPersonalDEBBACHE-BENAIDA, NADJETDSpacehttp://dspace.org/items/8f0da1de-6e78-4f94-a98a-46f126fea243DSpacehttp://dspace.org/items/8f0da1de-6e78-4f94-a98a-46f126fea243DEBBACHE-BENAIDANADJETORCIDhttp://orcid.org0000-0003-1561-7305PersonalPacheco, RitaDSpacehttp://dspace.org/items/d6907c0a-3f8f-431c-acf2-0b257692f0d4DSpacehttp://dspace.org/items/d6907c0a-3f8f-431c-acf2-0b257692f0d4PachecoRitaCiência IDhttps://www.ciencia-id.pt9F13-D310-B5A3ORCIDhttp://orcid.org0000-0001-5192-3006Researcher IDhttps://www.researcherid.comC-3062-2012Scopus Author IDhttps://www.scopus.com8853708300PersonalSerralheiro, Maria LuisaDSpacehttp://dspace.org/items/88895442-2a46-4878-a83f-435152a9cbb4DSpacehttp://dspace.org/items/88895442-2a46-4878-a83f-435152a9cbb4SerralheiroMaria LuisaORCIDhttp://orcid.org0000-0001-7541-9613Researcher IDhttps://www.researcherid.comE-3407-2012Scopus Author IDhttps://www.scopus.com6602688573PersonalAraujo, Maria EduardaDSpacehttp://dspace.org/items/ca23020f-df9d-4134-86d2-71dac7a97c1eDSpacehttp://dspace.org/items/ca23020f-df9d-4134-86d2-71dac7a97c1eAraujoMaria EduardaORCIDhttp://orcid.org0000-0002-9876-9015Researcher IDhttps://www.researcherid.comE-6528-2012Scopus Author IDhttps://www.scopus.com7202962614HostingInstitutionOrganizationalRCIPLe-mailmailto:rcaap@sp.ipl.ptrcaap@sp.ipl.ptISSNIsPartOf1876-3820ISSNIsPartOf1876-3839DOIIsPartOf10.1016/j.eujim.2018.11.0082019-02-08T14:37:06Z2019-012019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.21/9474http://purl.org/coar/access_right/c_16ecrestricted accessAlgerian honeysAnti-inflammatory activityAntioxidant activityAcetylcholinesterase inhibitionAlpha-Glucosidase inhibitionPhenolic compounds643529 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ipl.pt/bitstreams/47026846-410f-4261-bfab-e5c6f6391b14/downloadEuropean Journal of Integrative Medicine257784 |
| spellingShingle | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities Zaidi, Hicham Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| subject.fl_str_mv | Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| title | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| title_full | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| title_fullStr | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| title_full_unstemmed | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| title_short | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| title_sort | Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities |
| topic | Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| topic_facet | Algerian honeys Anti-inflammatory activity Antioxidant activity Acetylcholinesterase inhibition Alpha-Glucosidase inhibition Phenolic compounds |
| url | http://hdl.handle.net/10400.21/9474 |
| visible | 1 |