Publicação
The key role of sulfation and branching on fucoidan antitumor activity
| Resumo: | There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mLâ 1), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded Mw as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts. |
|---|---|
| Autores principais: | Oliveira, Catarina |
| Outros Autores: | Ferreira, Andreia S.; Novoa-Carballal, R.; Nunes, Cláudia; Pashkuleva, I.; Neves, N. M.; Coimbra, Manuel A.; Reis, R. L.; Martins, Albino; Silva, Tiago José Quinteiros Lopes Henriques |
| Assunto: | Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866269921175928832 |
|---|---|
| author | Oliveira, Catarina |
| author2 | Ferreira, Andreia S. Novoa-Carballal, R. Nunes, Cláudia Pashkuleva, I. Neves, N. M. Coimbra, Manuel A. Reis, R. L. Martins, Albino Silva, Tiago José Quinteiros Lopes Henriques |
| author2_role | author author author author author author author author author |
| author_facet | Oliveira, Catarina Ferreira, Andreia S. Novoa-Carballal, R. Nunes, Cláudia Pashkuleva, I. Neves, N. M. Coimbra, Manuel A. Reis, R. L. Martins, Albino Silva, Tiago José Quinteiros Lopes Henriques |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Oliveira, Catarina\"},{\"Person.name\":\"Ferreira, Andreia S.\"},{\"Person.name\":\"Novoa-Carballal, R.\"},{\"Person.name\":\"Nunes, Cláudia\"},{\"Person.name\":\"Pashkuleva, I.\"},{\"Person.name\":\"Neves, N. M.\"},{\"Person.name\":\"Coimbra, Manuel A.\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Martins, Albino\"},{\"Person.name\":\"Silva, Tiago José Quinteiros Lopes Henriques\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Oliveira, Catarina Ferreira, Andreia S. Novoa-Carballal, R. Nunes, Cláudia Pashkuleva, I. Neves, N. M. Coimbra, Manuel A. Reis, R. L. Martins, Albino Silva, Tiago José Quinteiros Lopes Henriques |
| datacite.date.Accepted.fl_str_mv | 2017-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2017-01-18T15:41:08Z |
| datacite.date.embargoed.fl_str_mv | 2017-01-18T15:41:08Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| datacite.titles.title.fl_str_mv | The key role of sulfation and branching on fucoidan antitumor activity |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Oliveira, Catarina Ferreira, Andreia S. Novoa-Carballal, R. Nunes, Cláudia Pashkuleva, I. Neves, N. M. Coimbra, Manuel A. Reis, R. L. Martins, Albino Silva, Tiago José Quinteiros Lopes Henriques |
| dc.date.Accepted.fl_str_mv | 2017-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2017-01-18T15:41:08Z |
| dc.date.embargoed.fl_str_mv | 2017-01-18T15:41:08Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/44382 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | John Wiley and Sons |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| dc.title.fl_str_mv | The key role of sulfation and branching on fucoidan antitumor activity |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mLâ 1), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded Mw as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/4dc138b6-29bd-48b9-a253-31b38035acb4/download |
| id | rum_051a597bd18caebdc6f330c00b869394 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/44382 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/44382 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Oliveira, Catarina Ferreira, Andreia S. Novoa-Carballal, R. Nunes, Cláudia Pashkuleva, I. Neves, N. M. Coimbra, Manuel A. Reis, R. L. Martins, Albino Silva, Tiago José Quinteiros Lopes Henriques |
| publishDate | 2017 |
| publisher.none.fl_str_mv | John Wiley and Sons |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engJohn Wiley and SonsporThere is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mLâ 1), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded Mw as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts.application/pdfporThe key role of sulfation and branching on fucoidan antitumor activityOliveira, CatarinaFerreira, Andreia S.Novoa-Carballal, R.Nunes, CláudiaPashkuleva, I.Neves, N. M.Coimbra, Manuel A.Reis, R. L.Martins, AlbinoSilva, Tiago José Quinteiros Lopes HenriquesHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1616-5195DOIIsPartOf10.1002/mabi.2016003402017-01-18T15:41:08Z20172017-012017-01-11T14:28:50Z2017-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/44382http://purl.org/coar/access_right/c_abf2open accessAntitumor activityFucoidanPolymer branchingStructure–activity relationshipSulfation2537622 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/4dc138b6-29bd-48b9-a253-31b38035acb4/download |
| spellingShingle | The key role of sulfation and branching on fucoidan antitumor activity Oliveira, Catarina Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| status | SINGLETON |
| subject.fl_str_mv | Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| title | The key role of sulfation and branching on fucoidan antitumor activity |
| title_full | The key role of sulfation and branching on fucoidan antitumor activity |
| title_fullStr | The key role of sulfation and branching on fucoidan antitumor activity |
| title_full_unstemmed | The key role of sulfation and branching on fucoidan antitumor activity |
| title_short | The key role of sulfation and branching on fucoidan antitumor activity |
| title_sort | The key role of sulfation and branching on fucoidan antitumor activity |
| topic | Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| topic_facet | Antitumor activity Fucoidan Polymer branching Structure–activity relationship Sulfation |
| url | https://hdl.handle.net/1822/44382 |
| visible | 1 |