Publicação
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents
| Resumo: | The synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy). |
|---|---|
| Autores principais: | André, João P. |
| Outros Autores: | Geraldes, Carlos F. G. C.; Martins, J. A. R.; Merbach, André E.; Prata, M. I. M.; Santos, A. C.; Lima, J. J. Pedroso de; Tóth, Éva |
| Assunto: | Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| Ano: | 2004 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866876485309038592 |
|---|---|
| author | André, João P. |
| author2 | Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
| author2_role | author author author author author author author |
| author_facet | André, João P. Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"André, João P.\"},{\"Person.name\":\"Geraldes, Carlos F. G. C.\"},{\"Person.name\":\"Martins, J. A. R.\"},{\"Person.name\":\"Merbach, André E.\"},{\"Person.name\":\"Prata, M. I. M.\"},{\"Person.name\":\"Santos, A. C.\"},{\"Person.name\":\"Lima, J. J. Pedroso de\"},{\"Person.name\":\"Tóth, Éva\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | André, João P. Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
| datacite.date.Accepted.fl_str_mv | 2004-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2005-03-30T14:54:31Z |
| datacite.date.embargoed.fl_str_mv | 2005-03-30T14:54:31Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| datacite.titles.title.fl_str_mv | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | André, João P. Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
| dc.date.Accepted.fl_str_mv | 2004-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2005-03-30T14:54:31Z |
| dc.date.embargoed.fl_str_mv | 2005-03-30T14:54:31Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/948 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| dc.title.fl_str_mv | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy). |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/abf308ae-06da-462f-afde-0add020a21cd/download |
| id | rum_15af8bb30c0d4c4f9ccbe2fefd0d3ff7 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/948 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/948 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | André, João P. Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
| publishDate | 2004 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWileyengThe synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy).application/pdfengLanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agentsAndré, João P.Geraldes, Carlos F. G. C.Martins, J. A. R.Merbach, André E.Prata, M. I. M.Santos, A. C.Lima, J. J. Pedroso deTóth, ÉvaHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf0947-6539DOIIsPartOf10.1002/chem.2004001872005-03-30T14:54:31Z20042004-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/948http://purl.org/coar/access_right/c_abf2open accessGlycoconjugatesLanthanidesLectinsMacrocyclesMagnetic resonance imaging294532 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/abf308ae-06da-462f-afde-0add020a21cd/download |
| spellingShingle | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents André, João P. Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| status | SINGLETON |
| subject.fl_str_mv | Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| title | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| title_full | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| title_fullStr | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| title_full_unstemmed | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| title_short | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| title_sort | Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
| topic | Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| topic_facet | Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging |
| url | https://hdl.handle.net/1822/948 |
| visible | 1 |