Publicação
Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
| Resumo: | Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors. |
|---|---|
| Autores principais: | Oliveira, Ana Isabel Ferreira |
| Outros Autores: | Magalhães, Ana Xavier Silva; Barbosa, Catarina Moreira; Magalhães, Hugo; Henrique, Rui; Jerónimo, Carmen; Costa, Bruno Marques |
| Assunto: | HOTAIR PCa rs12826786 rs920778 SNPs |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438378131128320 |
|---|---|
| author | Oliveira, Ana Isabel Ferreira |
| author2 | Magalhães, Ana Xavier Silva Barbosa, Catarina Moreira Magalhães, Hugo Henrique, Rui Jerónimo, Carmen Costa, Bruno Marques |
| author2_role | author author author author author author |
| author_facet | Oliveira, Ana Isabel Ferreira Magalhães, Ana Xavier Silva Barbosa, Catarina Moreira Magalhães, Hugo Henrique, Rui Jerónimo, Carmen Costa, Bruno Marques |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Oliveira, Ana Isabel Ferreira\"},{\"Person.name\":\"Magalhães, Ana Xavier Silva\"},{\"Person.name\":\"Barbosa, Catarina Moreira\"},{\"Person.name\":\"Magalhães, Hugo\"},{\"Person.name\":\"Henrique, Rui\"},{\"Person.name\":\"Jerónimo, Carmen\"},{\"Person.name\":\"Costa, Bruno Marques\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Oliveira, Ana Isabel Ferreira Magalhães, Ana Xavier Silva Barbosa, Catarina Moreira Magalhães, Hugo Henrique, Rui Jerónimo, Carmen Costa, Bruno Marques |
| datacite.date.Accepted.fl_str_mv | 2018-03-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | HOTAIR PCa rs12826786 rs920778 SNPs |
| datacite.titles.title.fl_str_mv | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Oliveira, Ana Isabel Ferreira Magalhães, Ana Xavier Silva Barbosa, Catarina Moreira Magalhães, Hugo Henrique, Rui Jerónimo, Carmen Costa, Bruno Marques |
| dc.date.Accepted.fl_str_mv | 2018-03-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/57921 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Future Medicine |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | HOTAIR PCa rs12826786 rs920778 SNPs |
| dc.title.fl_str_mv | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/1bf33a4c-9673-4081-ad33-7879fa043a98/download |
| id | rum_25fc950a0969e0dbc95d9301ac990ee8 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/57921 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/57921 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Oliveira, Ana Isabel Ferreira Magalhães, Ana Xavier Silva Barbosa, Catarina Moreira Magalhães, Hugo Henrique, Rui Jerónimo, Carmen Costa, Bruno Marques |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Future Medicine |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engFuture MedicineporAim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors.application/pdfporInfluence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survivalOliveira, Ana Isabel FerreiraMagalhães, Ana Xavier SilvaBarbosa, Catarina MoreiraMagalhães, HugoHenrique, RuiJerónimo, CarmenCosta, Bruno MarquesHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID29436234ISSNIsPartOf1752-0363EISSNIsPartOf1752-0371DOIIsPartOf10.2217/bmm-2017-02582018-032018-03-01T00:00:00ZHandlehttps://hdl.handle.net/1822/57921http://purl.org/coar/access_right/c_abf2open accessHOTAIRPCars12826786rs920778SNPs591654 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/1bf33a4c-9673-4081-ad33-7879fa043a98/download |
| spellingShingle | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival Oliveira, Ana Isabel Ferreira HOTAIR PCa rs12826786 rs920778 SNPs |
| status | SINGLETON |
| subject.fl_str_mv | HOTAIR PCa rs12826786 rs920778 SNPs |
| title | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| title_full | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| title_fullStr | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| title_full_unstemmed | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| title_short | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| title_sort | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival |
| topic | HOTAIR PCa rs12826786 rs920778 SNPs |
| topic_facet | HOTAIR PCa rs12826786 rs920778 SNPs |
| url | https://hdl.handle.net/1822/57921 |
| visible | 1 |