Publicação
Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration
| Resumo: | Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds, appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structuresalone or in combination with cells and bioactive molecules, bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces, furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites, have been employed. Particularly, significance is attributed to the natural-based biopolymer silk ï¬ broin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth. |
|---|---|
| Autores principais: | Ribeiro, Viviana Pinto |
| Outros Autores: | Pina, Sandra Cristina Almeida; Oliveira, J. M.; Reis, R. L. |
| Assunto: | Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866269278993383424 |
|---|---|
| author | Ribeiro, Viviana Pinto |
| author2 | Pina, Sandra Cristina Almeida Oliveira, J. M. Reis, R. L. |
| author2_role | author author author |
| author_facet | Ribeiro, Viviana Pinto Pina, Sandra Cristina Almeida Oliveira, J. M. Reis, R. L. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ribeiro, Viviana Pinto\"},{\"Person.name\":\"Pina, Sandra Cristina Almeida\"},{\"Person.name\":\"Oliveira, J. M.\"},{\"Person.name\":\"Reis, R. L.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Ribeiro, Viviana Pinto Pina, Sandra Cristina Almeida Oliveira, J. M. Reis, R. L. |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| datacite.titles.title.fl_str_mv | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Ribeiro, Viviana Pinto Pina, Sandra Cristina Almeida Oliveira, J. M. Reis, R. L. |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/56305 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| dc.title.fl_str_mv | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_3248 |
| description | Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds, appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structuresalone or in combination with cells and bioactive molecules, bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces, furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites, have been employed. Particularly, significance is attributed to the natural-based biopolymer silk ï¬ broin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | bookPart |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/b05a0cab-0349-43cb-877a-8d099c2a8de7/download |
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| identifier.url.fl_str_mv | https://hdl.handle.net/1822/56305 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/56305 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Ribeiro, Viviana Pinto Pina, Sandra Cristina Almeida Oliveira, J. M. Reis, R. L. |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Springer |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engSpringerporOsteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds, appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structuresalone or in combination with cells and bioactive molecules, bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces, furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites, have been employed. Particularly, significance is attributed to the natural-based biopolymer silk ï¬ broin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth.application/pdfporSilk fibroin-based hydrogels and scaffolds for osteochondral repair and regenerationRibeiro, Viviana PintoPina, Sandra Cristina AlmeidaOliveira, J. M.Reis, R. L.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISBNIsPartOf978-3-319-76710-9ISSNIsPartOf0065-2598DOIIsPartOf10.1007/978-3-319-76711-6_1420182018-022018-10-17T15:53:02Z2018-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/56305http://purl.org/coar/access_right/c_16ecrestricted accessHydrogelsOsteochondral regenerationScaffoldsSilk fibroin1181248 bytesliteraturehttp://purl.org/coar/resource_type/c_3248book parthttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/b05a0cab-0349-43cb-877a-8d099c2a8de7/download |
| spellingShingle | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration Ribeiro, Viviana Pinto Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| status | SINGLETON |
| subject.fl_str_mv | Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| title | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| title_full | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| title_fullStr | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| title_full_unstemmed | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| title_short | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| title_sort | Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration |
| topic | Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| topic_facet | Hydrogels Osteochondral regeneration Scaffolds Silk fibroin |
| url | https://hdl.handle.net/1822/56305 |
| visible | 1 |