Publicação
NIR triggered elastic liposome containing magneto-plasmonic nanoparticles for treatment of skin cancer
| Resumo: | Elastic liposomes (ELs) are excellent nanocarrier for topical applications due to their ultra-deformable properties. The integration of magnetic and plasmonic nanoparticles into these Els, forming magneto-plasmonic elastic liposomes, (MPELs) is a promising approach with potential to treat topical disease conditions. The combination of both magnetic and plasmonic components in a single system maximize the cell damage by increasing localized heat under a NIR laser [1,2], while being potential for magnetic hyperthermia and ideal as triggered drug delivery mediators. In this work, we report the design, development, and characterization of MPELs of DPPC:SP80 (85:15) containing cubic shaped calcium/magnesium ferrite nanoparticles coupled with gold nanorods (figure 1), for photothermal therapy (PTT). The structural, morphological, magnetic and photothermal properties of both magnetic and plasmonic components were evaluated. A new methodology was employed to couple the magnetic and plasmonic nanostructures, using cysteine as bridge molecule. The photothermal potential was evaluated for the magnetic nanoparticles, gold nanorods and the coupled magneto-plasmonic nanoparticles, displaying a maximum temperature variation of 28.9 ◦ , 33.6 ◦C and 37.2 ◦C, respectively, under NIR-laser irradiation. A phase transition temperature (Tm) of 35 ◦C was estimated for MPELs by, ensuring high fluidity for enhanced skin penetration. These findings point to the development of thermos-elastic nanocarriers with suitable features as photothermal hyperthermia agents. |
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| Autores principais: | Pacheco, Ana Rita Faria |
| Outros Autores: | Barros, Ana Margarida Macedo Veloso; Castanheira, Elisabete M. S.; Rodrigues, Ana Rita Oliveira |
| Assunto: | Calcium/magnesium ferrite Gold nanorods Elastic liposomes Photothermia |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Elastic liposomes (ELs) are excellent nanocarrier for topical applications due to their ultra-deformable properties. The integration of magnetic and plasmonic nanoparticles into these Els, forming magneto-plasmonic elastic liposomes, (MPELs) is a promising approach with potential to treat topical disease conditions. The combination of both magnetic and plasmonic components in a single system maximize the cell damage by increasing localized heat under a NIR laser [1,2], while being potential for magnetic hyperthermia and ideal as triggered drug delivery mediators. In this work, we report the design, development, and characterization of MPELs of DPPC:SP80 (85:15) containing cubic shaped calcium/magnesium ferrite nanoparticles coupled with gold nanorods (figure 1), for photothermal therapy (PTT). The structural, morphological, magnetic and photothermal properties of both magnetic and plasmonic components were evaluated. A new methodology was employed to couple the magnetic and plasmonic nanostructures, using cysteine as bridge molecule. The photothermal potential was evaluated for the magnetic nanoparticles, gold nanorods and the coupled magneto-plasmonic nanoparticles, displaying a maximum temperature variation of 28.9 ◦ , 33.6 ◦C and 37.2 ◦C, respectively, under NIR-laser irradiation. A phase transition temperature (Tm) of 35 ◦C was estimated for MPELs by, ensuring high fluidity for enhanced skin penetration. These findings point to the development of thermos-elastic nanocarriers with suitable features as photothermal hyperthermia agents. |
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