Detalhes bibliográficos
| Resumo: | The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age. |
|---|
| Autores principais: | Taipa, Ricardo Jorge Ferreira |
|---|
| Outros Autores: | Ferreira, V.; Brochado, P.; Robinson, A; Reis, I.; Marques, Fernanda; Mann, D. M.; Melo-Pires, M.; Sousa, Nuno |
|---|
| Assunto: | Ageing Alzheimer´s disease Astrocytes Microglia Pathology |
|---|
| Ano: | 2018 |
|---|
| País: | Portugal |
|---|
| Tipo de documento: | artigo |
|---|
| Tipo de acesso: | acesso aberto |
|---|
| Instituição associada: | Universidade do Minho |
|---|
| Idioma: | inglês |
|---|
| Origem: | RepositóriUM - Universidade do Minho |
|---|