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Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival

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Resumo:Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.
Autores principais:Gama, Adelina
Outros Autores:Paredes, Joana; Gärtner, Fátima; Alves, Anabela; Schmitt, Fernando
Assunto:Animals Biomarkers, Tumor Cadherins Disease-Free Survival Dog Diseases Dogs Female Immunohistochemistry Lymph Nodes Lymphatic Metastasis Mammary Neoplasms, Animal Neoplasm Invasiveness Prognosis Survival Analysis Beta Catenin Gene Expression Regulation, Neoplastic Canine Mammary tumours E-cadherin P-cadherin β-Catenin
Ano:2008
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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