Publicação
Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications
| Resumo: | Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young’s modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications. |
|---|---|
| Autores principais: | Amaro, Luís |
| Outros Autores: | Correia, D. M.; Marques-Almeida, Teresa; Martins, Pedro M.; Pérez, Leyre; Vilas, José L.; Botelho, Gabriela; Lanceros-Méndez, S.; Ribeiro, Clarisse |
| Assunto: | Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1864250755939041280 |
|---|---|
| author | Amaro, Luís |
| author2 | Correia, D. M. Marques-Almeida, Teresa Martins, Pedro M. Pérez, Leyre Vilas, José L. Botelho, Gabriela Lanceros-Méndez, S. Ribeiro, Clarisse |
| author2_role | author author author author author author author author |
| author_facet | Amaro, Luís Correia, D. M. Marques-Almeida, Teresa Martins, Pedro M. Pérez, Leyre Vilas, José L. Botelho, Gabriela Lanceros-Méndez, S. Ribeiro, Clarisse |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Amaro, Luís\"},{\"Person.name\":\"Correia, D. M.\"},{\"Person.name\":\"Marques-Almeida, Teresa\"},{\"Person.name\":\"Martins, Pedro M.\"},{\"Person.name\":\"Pérez, Leyre\"},{\"Person.name\":\"Vilas, José L.\"},{\"Person.name\":\"Botelho, Gabriela\"},{\"Person.name\":\"Lanceros-Méndez, S.\"},{\"Person.name\":\"Ribeiro, Clarisse\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Amaro, Luís Correia, D. M. Marques-Almeida, Teresa Martins, Pedro M. Pérez, Leyre Vilas, José L. Botelho, Gabriela Lanceros-Méndez, S. Ribeiro, Clarisse |
| datacite.date.Accepted.fl_str_mv | 2018-07-24T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-09-04T18:10:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-09-04T18:10:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| datacite.titles.title.fl_str_mv | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Amaro, Luís Correia, D. M. Marques-Almeida, Teresa Martins, Pedro M. Pérez, Leyre Vilas, José L. Botelho, Gabriela Lanceros-Méndez, S. Ribeiro, Clarisse |
| dc.date.Accepted.fl_str_mv | 2018-07-24T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-09-04T18:10:00Z |
| dc.date.embargoed.fl_str_mv | 2018-09-04T18:10:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/55733 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| dc.title.fl_str_mv | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young’s modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/728f23e9-2e8c-47fa-a1d1-e2e97a2cbcb0/download |
| id | rum_53738e63c105a537896d07d47b3cbe21 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/55733 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/55733 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Amaro, Luís Correia, D. M. Marques-Almeida, Teresa Martins, Pedro M. Pérez, Leyre Vilas, José L. Botelho, Gabriela Lanceros-Méndez, S. Ribeiro, Clarisse |
| publishDate | 2018 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMDPIporPolymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young’s modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications.application/pdfengTailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applicationsAmaro, LuísCorreia, D. M.Marques-Almeida, TeresaMartins, Pedro M.Pérez, LeyreVilas, José L.Botelho, GabrielaLanceros-Méndez, S.Ribeiro, ClarisseHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1661-6596DOIIsPartOf10.3390/ijms190821492018-09-04T18:10:00Z2018-07-242018-09-04T16:56:10Z2018-07-24T00:00:00ZHandlehttps://hdl.handle.net/1822/55733http://purl.org/coar/access_right/c_abf2open accessBiomaterialsCobalt ferritesPoly(hydroxybutyrate-co-hydroxyvalerate)Tissue engineering5787897 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/728f23e9-2e8c-47fa-a1d1-e2e97a2cbcb0/download |
| spellingShingle | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications Amaro, Luís Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| subject.fl_str_mv | Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| title | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| title_full | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| title_fullStr | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| title_full_unstemmed | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| title_short | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| title_sort | Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications |
| topic | Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| topic_facet | Biomaterials Cobalt ferrites Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering |
| url | https://hdl.handle.net/1822/55733 |
| visible | 1 |