Publicação
Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques
| Resumo: | Magneto-sensitive liposomes can be obtained by encapsulation of magnetic nanoparticles into liposomes or by the coverage of magnetic nanoparticles with a lipid bilayer. The so-called magnetoliposomes make possible to explore the synergistic effect between chemotherapy and magnetic hyperthermia in cancer therapeutics. Both aqueous magnetoliposomes (magnetic nanoparticles entrapped in liposomes) and solid magnetoliposomes (clusters of nanoparticles covered by a lipid bilayer), containing biocompatible magnetic nanoparticles, have been developed [1-3], exhibiting a superparamagnetic behavior and diameters below 150 nm. These nanosystems were successfully tested as nanocarriers for fluorescent potential antitumor drugs. Drug-loaded magnetoliposomes have shown the ability to interact by fusion with models of biomembranes [1-3] and to release the antitumor drugs in in vitro assays using human tumour cell lines [2]. Fluorescence-based methodologies, including Förster Resonance Energy Transfer (FRET), emission quenching and fluorescence anisotropy, have been used as valuable tools for this investigation. |
|---|---|
| Autores principais: | Cardoso, Beatriz D. |
| Outros Autores: | Pereira, Daniela S. M.; Rodrigues, Ana Rita Oliveira; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S. |
| Assunto: | Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866876384760037376 |
|---|---|
| author | Cardoso, Beatriz D. |
| author2 | Pereira, Daniela S. M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
| author2_role | author author author author |
| author_facet | Cardoso, Beatriz D. Pereira, Daniela S. M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Cardoso, Beatriz D.\"},{\"Person.name\":\"Pereira, Daniela S. M.\"},{\"Person.name\":\"Rodrigues, Ana Rita Oliveira\"},{\"Person.name\":\"Coutinho, Paulo J. G.\"},{\"Person.name\":\"Castanheira, Elisabete M. S.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Cardoso, Beatriz D. Pereira, Daniela S. M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
| datacite.date.Accepted.fl_str_mv | 2019-05-31T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-07-01T12:51:21Z |
| datacite.date.embargoed.fl_str_mv | 2019-07-01T12:51:21Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| datacite.titles.title.fl_str_mv | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Cardoso, Beatriz D. Pereira, Daniela S. M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
| dc.date.Accepted.fl_str_mv | 2019-05-31T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-07-01T12:51:21Z |
| dc.date.embargoed.fl_str_mv | 2019-07-01T12:51:21Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/60729 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Óptica e Fotónica |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| dc.title.fl_str_mv | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_1843 |
| description | Magneto-sensitive liposomes can be obtained by encapsulation of magnetic nanoparticles into liposomes or by the coverage of magnetic nanoparticles with a lipid bilayer. The so-called magnetoliposomes make possible to explore the synergistic effect between chemotherapy and magnetic hyperthermia in cancer therapeutics. Both aqueous magnetoliposomes (magnetic nanoparticles entrapped in liposomes) and solid magnetoliposomes (clusters of nanoparticles covered by a lipid bilayer), containing biocompatible magnetic nanoparticles, have been developed [1-3], exhibiting a superparamagnetic behavior and diameters below 150 nm. These nanosystems were successfully tested as nanocarriers for fluorescent potential antitumor drugs. Drug-loaded magnetoliposomes have shown the ability to interact by fusion with models of biomembranes [1-3] and to release the antitumor drugs in in vitro assays using human tumour cell lines [2]. Fluorescence-based methodologies, including Förster Resonance Energy Transfer (FRET), emission quenching and fluorescence anisotropy, have been used as valuable tools for this investigation. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | other |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/f5b3694e-4b9a-4ce3-8604-47953be64328/download |
| id | rum_59ea1ad259a4e0f8fb649c8e753e95ca |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/60729 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/60729 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Cardoso, Beatriz D. Pereira, Daniela S. M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Óptica e Fotónica |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engSociedade Portuguesa de Óptica e FotónicaporMagneto-sensitive liposomes can be obtained by encapsulation of magnetic nanoparticles into liposomes or by the coverage of magnetic nanoparticles with a lipid bilayer. The so-called magnetoliposomes make possible to explore the synergistic effect between chemotherapy and magnetic hyperthermia in cancer therapeutics. Both aqueous magnetoliposomes (magnetic nanoparticles entrapped in liposomes) and solid magnetoliposomes (clusters of nanoparticles covered by a lipid bilayer), containing biocompatible magnetic nanoparticles, have been developed [1-3], exhibiting a superparamagnetic behavior and diameters below 150 nm. These nanosystems were successfully tested as nanocarriers for fluorescent potential antitumor drugs. Drug-loaded magnetoliposomes have shown the ability to interact by fusion with models of biomembranes [1-3] and to release the antitumor drugs in in vitro assays using human tumour cell lines [2]. Fluorescence-based methodologies, including Förster Resonance Energy Transfer (FRET), emission quenching and fluorescence anisotropy, have been used as valuable tools for this investigation.application/pdfporDevelopment of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniquesCardoso, Beatriz D.Pereira, Daniela S. M.Rodrigues, Ana Rita OliveiraCoutinho, Paulo J. G.Castanheira, Elisabete M. S.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.pt2019-07-01T12:51:21Z2019-05-312019-05-31T00:00:00ZHandlehttps://hdl.handle.net/1822/60729http://purl.org/coar/access_right/c_abf2open accessMagnetic nanoparticlesMagnetoliposomesFluorescenceDrug delivery7759 bytesother research producthttp://purl.org/coar/resource_type/c_1843other2019-05-31http://creativecommons.org/licenses/by-nc/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/f5b3694e-4b9a-4ce3-8604-47953be64328/download |
| spellingShingle | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques Cardoso, Beatriz D. Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| status | SINGLETON |
| subject.fl_str_mv | Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| title | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| title_full | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| title_fullStr | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| title_full_unstemmed | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| title_short | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| title_sort | Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques |
| topic | Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| topic_facet | Magnetic nanoparticles Magnetoliposomes Fluorescence Drug delivery |
| url | https://hdl.handle.net/1822/60729 |
| visible | 1 |