Publicação
Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology
| Resumo: | Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimerâ Au complex-based nanoparticles. Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the potential of dendrimerâ Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs. |
|---|---|
| Autores principais: | Milivojevic, Nevena |
| Outros Autores: | Carvalho, Mariana Rodrigues; Caballero, David; Radisavljevic, Snezana; Radoicic, Marija; Živanović, Marko; Kundu, Subhas C; Reis, R. L.; Filipović, Nenad; Oliveira, Joaquim M. |
| Assunto: | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866876679809400832 |
|---|---|
| author | Milivojevic, Nevena |
| author2 | Carvalho, Mariana Rodrigues Caballero, David Radisavljevic, Snezana Radoicic, Marija Živanović, Marko Kundu, Subhas C Reis, R. L. Filipović, Nenad Oliveira, Joaquim M. |
| author2_role | author author author author author author author author author |
| author_facet | Milivojevic, Nevena Carvalho, Mariana Rodrigues Caballero, David Radisavljevic, Snezana Radoicic, Marija Živanović, Marko Kundu, Subhas C Reis, R. L. Filipović, Nenad Oliveira, Joaquim M. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Milivojevic, Nevena\"},{\"Person.name\":\"Carvalho, Mariana Rodrigues\"},{\"Person.name\":\"Caballero, David\"},{\"Person.name\":\"Radisavljevic, Snezana\"},{\"Person.name\":\"Radoicic, Marija\"},{\"Person.name\":\"Živanović, Marko\"},{\"Person.name\":\"Kundu, Subhas C\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Filipović, Nenad\"},{\"Person.name\":\"Oliveira, Joaquim M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Milivojevic, Nevena Carvalho, Mariana Rodrigues Caballero, David Radisavljevic, Snezana Radoicic, Marija Živanović, Marko Kundu, Subhas C Reis, R. L. Filipović, Nenad Oliveira, Joaquim M. |
| datacite.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-03-26T11:05:26Z |
| datacite.date.embargoed.fl_str_mv | 2024-03-26T11:05:26Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| datacite.titles.title.fl_str_mv | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Milivojevic, Nevena Carvalho, Mariana Rodrigues Caballero, David Radisavljevic, Snezana Radoicic, Marija Živanović, Marko Kundu, Subhas C Reis, R. L. Filipović, Nenad Oliveira, Joaquim M. |
| dc.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-03-26T11:05:26Z |
| dc.date.embargoed.fl_str_mv | 2024-03-26T11:05:26Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/90035 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Taylor & Francis |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| dc.title.fl_str_mv | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimerâ Au complex-based nanoparticles. Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the potential of dendrimerâ Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/464b52d2-fc76-4f09-a240-4fa814ea363b/download |
| id | rum_62201b3fd3af8136c577caa2d3e49d6d |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/90035 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/90035 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Milivojevic, Nevena Carvalho, Mariana Rodrigues Caballero, David Radisavljevic, Snezana Radoicic, Marija Živanović, Marko Kundu, Subhas C Reis, R. L. Filipović, Nenad Oliveira, Joaquim M. |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Taylor & Francis |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engTaylor & FrancisporAim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimerâ Au complex-based nanoparticles. Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the potential of dendrimerâ Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs.application/pdfporEvaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncologyMilivojevic, NevenaCarvalho, Mariana RodriguesCaballero, DavidRadisavljevic, SnezanaRadoicic, MarijaŽivanović, MarkoKundu, Subhas CReis, R. L.Filipović, NenadOliveira, Joaquim M.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1743-5889DOIIsPartOf10.2217/nnm-2023-03552024-03-26T11:05:26Z2024-012023-12-142024-03-21T09:30:35Z2024-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/90035http://purl.org/coar/access_right/c_abf2open accessDendrimersMicrofluidicsNanoparticlesAu-complexColorectal cancerDendrimer nanoparticlesNano-oncologyNanomedicine12320678 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2024-01http://creativecommons.org/licenses/by-nc-nd/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/464b52d2-fc76-4f09-a240-4fa814ea363b/download |
| spellingShingle | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology Milivojevic, Nevena Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| status | SINGLETON |
| subject.fl_str_mv | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| title | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| title_full | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| title_fullStr | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| title_full_unstemmed | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| title_short | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| title_sort | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
| topic | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| topic_facet | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
| url | https://hdl.handle.net/1822/90035 |
| visible | 1 |