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Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology

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Resumo:Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimerâ Au complex-based nanoparticles. Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the potential of dendrimerâ Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs.
Autores principais:Milivojevic, Nevena
Outros Autores:Carvalho, Mariana Rodrigues; Caballero, David; Radisavljevic, Snezana; Radoicic, Marija; Živanović, Marko; Kundu, Subhas C; Reis, R. L.; Filipović, Nenad; Oliveira, Joaquim M.
Assunto:Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine
Ano:2024
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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