Publicação
Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications
| Resumo: | The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step was necessary to render the membrane insoluble in water and stable at physiological conditions. Crosslinked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mechanism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechanical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as a wound dressing. |
|---|---|
| Autores principais: | Alves, A. |
| Outros Autores: | Pinho, Elisabete D.; Neves, N. M.; Sousa, R. A.; Reis, R. L. |
| Assunto: | Ulvan Membrane Dressing Medicated dressing Drug delivery |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438295703617536 |
|---|---|
| author | Alves, A. |
| author2 | Pinho, Elisabete D. Neves, N. M. Sousa, R. A. Reis, R. L. |
| author2_role | author author author author |
| author_facet | Alves, A. Pinho, Elisabete D. Neves, N. M. Sousa, R. A. Reis, R. L. |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Alves, A.\"},{\"Person.name\":\"Pinho, Elisabete D.\"},{\"Person.name\":\"Neves, N. M.\"},{\"Person.name\":\"Sousa, R. A.\"},{\"Person.name\":\"Reis, R. L.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Alves, A. Pinho, Elisabete D. Neves, N. M. Sousa, R. A. Reis, R. L. |
| datacite.date.Accepted.fl_str_mv | 2012-04-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2012-05-18T11:08:23Z |
| datacite.date.embargoed.fl_str_mv | 2012-05-18T11:08:23Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Ulvan Membrane Dressing Medicated dressing Drug delivery |
| datacite.titles.title.fl_str_mv | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Alves, A. Pinho, Elisabete D. Neves, N. M. Sousa, R. A. Reis, R. L. |
| dc.date.Accepted.fl_str_mv | 2012-04-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2012-05-18T11:08:23Z |
| dc.date.embargoed.fl_str_mv | 2012-05-18T11:08:23Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/19387 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Ulvan Membrane Dressing Medicated dressing Drug delivery |
| dc.title.fl_str_mv | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step was necessary to render the membrane insoluble in water and stable at physiological conditions. Crosslinked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mechanism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechanical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as a wound dressing. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/86d569c6-6663-4074-b8e7-760889a42c02/download |
| id | rum_666db22ef3392cd8a735e90e18cdeada |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/19387 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/19387 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Alves, A. Pinho, Elisabete D. Neves, N. M. Sousa, R. A. Reis, R. L. |
| publishDate | 2012 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engElsevierporThe polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step was necessary to render the membrane insoluble in water and stable at physiological conditions. Crosslinked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mechanism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechanical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as a wound dressing.application/pdfporProcessing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applicationsAlves, A.Pinho, Elisabete D.Neves, N. M.Sousa, R. A.Reis, R. L.HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID22281048ISSNIsPartOf0378-5173DOIIsPartOf10.1016/j.ijpharm.2012.01.0212012-05-18T11:08:23Z2012-042012-04-01T00:00:00ZHandlehttps://hdl.handle.net/1822/19387http://purl.org/coar/access_right/c_16ecrestricted accessUlvanMembraneDressingMedicated dressingDrug delivery552215 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorium.uminho.pt/bitstreams/86d569c6-6663-4074-b8e7-760889a42c02/download |
| spellingShingle | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications Alves, A. Ulvan Membrane Dressing Medicated dressing Drug delivery |
| status | SINGLETON |
| subject.fl_str_mv | Ulvan Membrane Dressing Medicated dressing Drug delivery |
| title | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| title_full | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| title_fullStr | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| title_full_unstemmed | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| title_short | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| title_sort | Processing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applications |
| topic | Ulvan Membrane Dressing Medicated dressing Drug delivery |
| topic_facet | Ulvan Membrane Dressing Medicated dressing Drug delivery |
| url | https://hdl.handle.net/1822/19387 |
| visible | 1 |