Publicação
Keratin/chitosan as novel grafts for peripheral nerve regeneration
| Resumo: | For many years Peripheral Nerve Injuries (PNI) has been raising major concerns in regenerative medicine. Currently, the gold standard treatment for PNI is the autologous nerve grafting but it presents several drawbacks. Chitosan, along with keratin [1], for their good biocompatibility and physicochemical properties have been widely used as biomaterials in tissue engineering scaffolding. Many engineered biomaterials, natural or synthetic, have also been studied, but its poor architecture and lack of appropriate biological cues have been limiting nerve tissue regeneration [2]. In this study, an innovative combination of chitosan and keratin is obtained in order to create a novel nerve conduit (medical device) aimed at finding applications in the treatment of PNI. |
|---|---|
| Autores principais: | Carvalho, C. R. |
| Outros Autores: | Pedro, A. J.; Ng, K. W.; Neves, N. M.; Reis, R. L.; Oliveira, M. |
| Assunto: | Keratin chitosan Peripheral nerve regeneration |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866270193072734208 |
|---|---|
| author | Carvalho, C. R. |
| author2 | Pedro, A. J. Ng, K. W. Neves, N. M. Reis, R. L. Oliveira, M. |
| author2_role | author author author author author |
| author_facet | Carvalho, C. R. Pedro, A. J. Ng, K. W. Neves, N. M. Reis, R. L. Oliveira, M. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Carvalho, C. R.\"},{\"Person.name\":\"Pedro, A. J.\"},{\"Person.name\":\"Ng, K. W.\"},{\"Person.name\":\"Neves, N. M.\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Oliveira, M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Carvalho, C. R. Pedro, A. J. Ng, K. W. Neves, N. M. Reis, R. L. Oliveira, M. |
| datacite.date.Accepted.fl_str_mv | 2014-06-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-01-16T15:18:38Z |
| datacite.date.embargoed.fl_str_mv | 2015-01-16T15:18:38Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Keratin chitosan Peripheral nerve regeneration |
| datacite.titles.title.fl_str_mv | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Carvalho, C. R. Pedro, A. J. Ng, K. W. Neves, N. M. Reis, R. L. Oliveira, M. |
| dc.date.Accepted.fl_str_mv | 2014-06-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-01-16T15:18:38Z |
| dc.date.embargoed.fl_str_mv | 2015-01-16T15:18:38Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/32934 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | John Wiley and Sons |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Keratin chitosan Peripheral nerve regeneration |
| dc.title.fl_str_mv | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_1843 |
| description | For many years Peripheral Nerve Injuries (PNI) has been raising major concerns in regenerative medicine. Currently, the gold standard treatment for PNI is the autologous nerve grafting but it presents several drawbacks. Chitosan, along with keratin [1], for their good biocompatibility and physicochemical properties have been widely used as biomaterials in tissue engineering scaffolding. Many engineered biomaterials, natural or synthetic, have also been studied, but its poor architecture and lack of appropriate biological cues have been limiting nerve tissue regeneration [2]. In this study, an innovative combination of chitosan and keratin is obtained in order to create a novel nerve conduit (medical device) aimed at finding applications in the treatment of PNI. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | other |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/3d8cf4c2-1f0c-4d6d-a5e7-ab1f456eb4cf/download |
| id | rum_66ffd1fb2fa250386ca1ce7afc6c710d |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/32934 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/32934 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Carvalho, C. R. Pedro, A. J. Ng, K. W. Neves, N. M. Reis, R. L. Oliveira, M. |
| publishDate | 2014 |
| publisher.none.fl_str_mv | John Wiley and Sons |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engJohn Wiley and SonsporFor many years Peripheral Nerve Injuries (PNI) has been raising major concerns in regenerative medicine. Currently, the gold standard treatment for PNI is the autologous nerve grafting but it presents several drawbacks. Chitosan, along with keratin [1], for their good biocompatibility and physicochemical properties have been widely used as biomaterials in tissue engineering scaffolding. Many engineered biomaterials, natural or synthetic, have also been studied, but its poor architecture and lack of appropriate biological cues have been limiting nerve tissue regeneration [2]. In this study, an innovative combination of chitosan and keratin is obtained in order to create a novel nerve conduit (medical device) aimed at finding applications in the treatment of PNI.application/pdfporKeratin/chitosan as novel grafts for peripheral nerve regenerationCarvalho, C. R.Pedro, A. J.Ng, K. W.Neves, N. M.Reis, R. L.Oliveira, M.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1932-62542015-01-16T15:18:38Z2014-0620142015-01-15T14:21:56Z2014-06-01T00:00:00ZHandlehttps://hdl.handle.net/1822/32934http://purl.org/coar/access_right/c_abf2open accessKeratin chitosanPeripheral nerve regeneration164260 bytesother research producthttp://purl.org/coar/resource_type/c_1843otherhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/3d8cf4c2-1f0c-4d6d-a5e7-ab1f456eb4cf/download |
| spellingShingle | Keratin/chitosan as novel grafts for peripheral nerve regeneration Carvalho, C. R. Keratin chitosan Peripheral nerve regeneration |
| status | SINGLETON |
| subject.fl_str_mv | Keratin chitosan Peripheral nerve regeneration |
| title | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| title_full | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| title_fullStr | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| title_full_unstemmed | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| title_short | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| title_sort | Keratin/chitosan as novel grafts for peripheral nerve regeneration |
| topic | Keratin chitosan Peripheral nerve regeneration |
| topic_facet | Keratin chitosan Peripheral nerve regeneration |
| url | https://hdl.handle.net/1822/32934 |
| visible | 1 |