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Medullary control of nociceptive transmission: reciprocal dual communication with the spinal cord

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Summary:Control of pain perception, essential for organism surviving and recovery from disease, is exerted by higher brain centers integrating nociception with emotional and cognitive information and modulating the brainstem-spinal feedback loops that regulate spinal nociceptive transmission. Development of chronic pain deregulates the forebrain-brainstem-spinal pain control system, which leads to neuroplasticity and disruption of a balanced brain-spinal communication. Targets for impeding pain chronification are being developed using the manipulation of the cross talk between brain and dorsal horn, at both sites of the loop.
Main Authors:Almeida, Armando
Other Authors:Almeida, Hugo Leite; Tavares, Isaura
Subject:Pain modulation Pain facilitation Pain inhibition Antinociception Pronociception Brainstem DRt VLMLat LRt Brain-spinal cord circuits Spinal cord Nociception
Year:2006
Country:Portugal
Document type:article
Access type:open access
Associated institution:Universidade do Minho
Language:English
Origin:RepositóriUM - Universidade do Minho

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