Publicação
Mild two-step conversion of primary amides to alcohols by reduction of acylimidodicarbonates with sodium borohydride
| Resumo: | Di-tert-butyl acylimidodicarbonates, prepared from primary amides with two equivalents of di-tert-butyl dicarbonate under catalysis by 4-dimethylaminopyridine, readily undergo selective reductive cleavage of their acyl CO-N bonds by NaBH4 to provide the corresponding alcohols in high yields. |
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| Autores principais: | Ragnarsson, Ulf |
| Outros Autores: | Grehn, Leif; Monteiro, Luís S.; Maia, Hernâni Lopes Silva |
| Assunto: | Alcohols Amides Cleavage reductions sodium borohydride |
| Ano: | 2003 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Di-tert-butyl acylimidodicarbonates, prepared from primary amides with two equivalents of di-tert-butyl dicarbonate under catalysis by 4-dimethylaminopyridine, readily undergo selective reductive cleavage of their acyl CO-N bonds by NaBH4 to provide the corresponding alcohols in high yields. |
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