Publicação
ChemT, an open-source software for building template-based chemical libraries
| Resumo: | In computational chemistry vast quantities of compounds are generated, and there is a need for cheminformatic tools to efficiently build chemical compound libraries. Several software tools for drawing and editing compounds structures are available, but they lack options for automatic generation of chemical libraries. We have implemented ChemT, an easy-to-use open-source software tool that automates the process of preparing custom-made template-based chemical libraries. ChemT automatically generates three-dimensional chemical libraries by inputting a chemical template and the functional groups of interest. The graphical user interface of ChemT is self-explanatory, and a complete tutorial is provided. Several file formats are accepted by ChemT, and it is possible to filter the generated compounds according to different physicochemical properties. The compounds can be subject to force field minimization, and the resulting three-dimensional structures recorded on commonly used file formats. ChemT may be a valuable tool for investigators interested in using in silico virtual screening tools, like QSAR modelling or molecular docking, in order to prioritize compounds for further chemical synthesis. To demonstrate the usefulness of ChemT, we describe an example based on a thieno[3,2-b]pyridine template. |
|---|---|
| Autores principais: | Abreu, Rui M. V. |
| Outros Autores: | Froufe, Hugo J. C.; Daniel, P. O. M.; Queiroz, Maria João R. P.; Ferreira, Isabel C. F. R. |
| Assunto: | ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| Ano: | 2011 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867439811555491840 |
|---|---|
| author | Abreu, Rui M. V. |
| author2 | Froufe, Hugo J. C. Daniel, P. O. M. Queiroz, Maria João R. P. Ferreira, Isabel C. F. R. |
| author2_role | author author author author |
| author_facet | Abreu, Rui M. V. Froufe, Hugo J. C. Daniel, P. O. M. Queiroz, Maria João R. P. Ferreira, Isabel C. F. R. |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Abreu, Rui M. V.\"},{\"Person.name\":\"Froufe, Hugo J. C.\"},{\"Person.name\":\"Daniel, P. O. M.\"},{\"Person.name\":\"Queiroz, Maria João R. P.\"},{\"Person.name\":\"Ferreira, Isabel C. F. R.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Abreu, Rui M. V. Froufe, Hugo J. C. Daniel, P. O. M. Queiroz, Maria João R. P. Ferreira, Isabel C. F. R. |
| datacite.date.Accepted.fl_str_mv | 2011-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2011-11-14T17:21:47Z |
| datacite.date.embargoed.fl_str_mv | 2011-11-14T17:21:47Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| datacite.titles.title.fl_str_mv | ChemT, an open-source software for building template-based chemical libraries |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Abreu, Rui M. V. Froufe, Hugo J. C. Daniel, P. O. M. Queiroz, Maria João R. P. Ferreira, Isabel C. F. R. |
| dc.date.Accepted.fl_str_mv | 2011-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2011-11-14T17:21:47Z |
| dc.date.embargoed.fl_str_mv | 2011-11-14T17:21:47Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/14308 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Taylor and Francis |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| dc.title.fl_str_mv | ChemT, an open-source software for building template-based chemical libraries |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | In computational chemistry vast quantities of compounds are generated, and there is a need for cheminformatic tools to efficiently build chemical compound libraries. Several software tools for drawing and editing compounds structures are available, but they lack options for automatic generation of chemical libraries. We have implemented ChemT, an easy-to-use open-source software tool that automates the process of preparing custom-made template-based chemical libraries. ChemT automatically generates three-dimensional chemical libraries by inputting a chemical template and the functional groups of interest. The graphical user interface of ChemT is self-explanatory, and a complete tutorial is provided. Several file formats are accepted by ChemT, and it is possible to filter the generated compounds according to different physicochemical properties. The compounds can be subject to force field minimization, and the resulting three-dimensional structures recorded on commonly used file formats. ChemT may be a valuable tool for investigators interested in using in silico virtual screening tools, like QSAR modelling or molecular docking, in order to prioritize compounds for further chemical synthesis. To demonstrate the usefulness of ChemT, we describe an example based on a thieno[3,2-b]pyridine template. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/ddd61173-259e-4a72-9467-758dbb5fcc32/download |
| id | rum_7e2cb558fd06cda29227d8f983e7dbe5 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/14308 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/14308 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Abreu, Rui M. V. Froufe, Hugo J. C. Daniel, P. O. M. Queiroz, Maria João R. P. Ferreira, Isabel C. F. R. |
| publishDate | 2011 |
| publisher.none.fl_str_mv | Taylor and Francis |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engTaylor and FrancisporIn computational chemistry vast quantities of compounds are generated, and there is a need for cheminformatic tools to efficiently build chemical compound libraries. Several software tools for drawing and editing compounds structures are available, but they lack options for automatic generation of chemical libraries. We have implemented ChemT, an easy-to-use open-source software tool that automates the process of preparing custom-made template-based chemical libraries. ChemT automatically generates three-dimensional chemical libraries by inputting a chemical template and the functional groups of interest. The graphical user interface of ChemT is self-explanatory, and a complete tutorial is provided. Several file formats are accepted by ChemT, and it is possible to filter the generated compounds according to different physicochemical properties. The compounds can be subject to force field minimization, and the resulting three-dimensional structures recorded on commonly used file formats. ChemT may be a valuable tool for investigators interested in using in silico virtual screening tools, like QSAR modelling or molecular docking, in order to prioritize compounds for further chemical synthesis. To demonstrate the usefulness of ChemT, we describe an example based on a thieno[3,2-b]pyridine template.application/pdfporChemT, an open-source software for building template-based chemical librariesAbreu, Rui M. V.Froufe, Hugo J. C.Daniel, P. O. M.Queiroz, Maria João R. P.Ferreira, Isabel C. F. R.HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID21846264ISSNIsPartOf1062-936XISSNIsPartOf1029-046XDOIIsPartOf10.1080/1062936X.2011.6040972011-11-14T17:21:47Z20112011-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/14308http://purl.org/coar/access_right/c_abf2open accessChemTQSARChemical libraryVirtual screeningDrug discoveryquantitative structure-activity relationship82994 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/ddd61173-259e-4a72-9467-758dbb5fcc32/download |
| spellingShingle | ChemT, an open-source software for building template-based chemical libraries Abreu, Rui M. V. ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| status | SINGLETON |
| subject.fl_str_mv | ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| title | ChemT, an open-source software for building template-based chemical libraries |
| title_full | ChemT, an open-source software for building template-based chemical libraries |
| title_fullStr | ChemT, an open-source software for building template-based chemical libraries |
| title_full_unstemmed | ChemT, an open-source software for building template-based chemical libraries |
| title_short | ChemT, an open-source software for building template-based chemical libraries |
| title_sort | ChemT, an open-source software for building template-based chemical libraries |
| topic | ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| topic_facet | ChemT QSAR Chemical library Virtual screening Drug discovery quantitative structure-activity relationship |
| url | https://hdl.handle.net/1822/14308 |
| visible | 1 |