Publicação
Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy
| Resumo: | Supramolecular hydrogels are highly promising for biomedical materials owing to the wide array of properties that can be tailored and modulated. The combination with plasmonic/magnetic nanoparticles into plasmonic magnetogels further improve its potential in biomedical applications, through the combination of complementary strategies, such as photothermia, magnetic hyperthermia, photodynamic therapy and magnetic-guided drug delivery. Here, a new dehydropeptide hydrogelator, Npx-L-Met-Z-ΔPhe-OH, was developed and combined with two different plasmonic/magnetic nanoparticles architectures: core/shell manganese ferrite/gold nanoparticles or gold-decorated manganese ferrite nanoparticles with ca. 55 nm and 45 nm size, respectively. The characterization of magnetogels were performed by HR-TEM, FTIR, circular dichorism and rheological assays. The gels were tested as nanocarriers for a model antitumor drug, the natural compound curcumin. The incorporation of the drug in magnetogel matrices was confirmed through fluorescence-based techniques (FRET, fluorescence anisotropy and quenching). The curcumin release profiles were studied with and without excitation of the gold plasmon band. The transport of curcumin from magnetogels towards biomembrane models (small unilamellar vesicles) was assessed by FRET between the fluorescent drug and the lipid probe Nile Red. The developed magnetogels showed promising results for photothermia and photo-triggered drug release. The magnetogels bearing gold-decorated nanoparticles showed the best photothermia properties, while the ones containing core/shell nanoparticles had the best photoinduced curcumin release. |
|---|---|
| Autores principais: | Veloso, Sérgio Rafael Silva |
| Outros Autores: | Martins, J. A. R.; Hilliou, L.; Amorim, C. O.; Amaral, V. S.; Almeida, B. G.; Jervis, Peter John; Moreira, R.; Pereira, D. M.; Coutinho, Paulo J. G.; Ferreira, Paula M. T.; Castanheira, Elisabete M. S. |
| Assunto: | magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1864250725516705792 |
|---|---|
| author | Veloso, Sérgio Rafael Silva |
| author2 | Martins, J. A. R. Hilliou, L. Amorim, C. O. Amaral, V. S. Almeida, B. G. Jervis, Peter John Moreira, R. Pereira, D. M. Coutinho, Paulo J. G. Ferreira, Paula M. T. Castanheira, Elisabete M. S. |
| author2_role | author author author author author author author author author author author |
| author_facet | Veloso, Sérgio Rafael Silva Martins, J. A. R. Hilliou, L. Amorim, C. O. Amaral, V. S. Almeida, B. G. Jervis, Peter John Moreira, R. Pereira, D. M. Coutinho, Paulo J. G. Ferreira, Paula M. T. Castanheira, Elisabete M. S. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Veloso, Sérgio Rafael Silva\"},{\"Person.name\":\"Martins, J. A. R.\"},{\"Person.name\":\"Hilliou, L.\"},{\"Person.name\":\"Amorim, C. O.\"},{\"Person.name\":\"Amaral, V. S.\"},{\"Person.name\":\"Almeida, B. G.\"},{\"Person.name\":\"Jervis, Peter John\"},{\"Person.name\":\"Moreira, R.\"},{\"Person.name\":\"Pereira, D. M.\"},{\"Person.name\":\"Coutinho, Paulo J. G.\"},{\"Person.name\":\"Ferreira, Paula M. T.\"},{\"Person.name\":\"Castanheira, Elisabete M. S.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Veloso, Sérgio Rafael Silva Martins, J. A. R. Hilliou, L. Amorim, C. O. Amaral, V. S. Almeida, B. G. Jervis, Peter John Moreira, R. Pereira, D. M. Coutinho, Paulo J. G. Ferreira, Paula M. T. Castanheira, Elisabete M. S. |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-11-11T07:00:16Z |
| datacite.date.embargoed.fl_str_mv | 2020-11-11T07:00:16Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| datacite.titles.title.fl_str_mv | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Veloso, Sérgio Rafael Silva Martins, J. A. R. Hilliou, L. Amorim, C. O. Amaral, V. S. Almeida, B. G. Jervis, Peter John Moreira, R. Pereira, D. M. Coutinho, Paulo J. G. Ferreira, Paula M. T. Castanheira, Elisabete M. S. |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-11-11T07:00:16Z |
| dc.date.embargoed.fl_str_mv | 2020-11-11T07:00:16Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/62170 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Royal Society of Chemistry |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| dc.title.fl_str_mv | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Supramolecular hydrogels are highly promising for biomedical materials owing to the wide array of properties that can be tailored and modulated. The combination with plasmonic/magnetic nanoparticles into plasmonic magnetogels further improve its potential in biomedical applications, through the combination of complementary strategies, such as photothermia, magnetic hyperthermia, photodynamic therapy and magnetic-guided drug delivery. Here, a new dehydropeptide hydrogelator, Npx-L-Met-Z-ΔPhe-OH, was developed and combined with two different plasmonic/magnetic nanoparticles architectures: core/shell manganese ferrite/gold nanoparticles or gold-decorated manganese ferrite nanoparticles with ca. 55 nm and 45 nm size, respectively. The characterization of magnetogels were performed by HR-TEM, FTIR, circular dichorism and rheological assays. The gels were tested as nanocarriers for a model antitumor drug, the natural compound curcumin. The incorporation of the drug in magnetogel matrices was confirmed through fluorescence-based techniques (FRET, fluorescence anisotropy and quenching). The curcumin release profiles were studied with and without excitation of the gold plasmon band. The transport of curcumin from magnetogels towards biomembrane models (small unilamellar vesicles) was assessed by FRET between the fluorescent drug and the lipid probe Nile Red. The developed magnetogels showed promising results for photothermia and photo-triggered drug release. The magnetogels bearing gold-decorated nanoparticles showed the best photothermia properties, while the ones containing core/shell nanoparticles had the best photoinduced curcumin release. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/8a33961c-bdc3-4dab-ace6-59386dddc57b/download |
| id | rum_8cd6b4e3cd7eb209de1386a8fb0db87f |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/62170 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/62170 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Veloso, Sérgio Rafael Silva Martins, J. A. R. Hilliou, L. Amorim, C. O. Amaral, V. S. Almeida, B. G. Jervis, Peter John Moreira, R. Pereira, D. M. Coutinho, Paulo J. G. Ferreira, Paula M. T. Castanheira, Elisabete M. S. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Royal Society of Chemistry |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engRoyal Society of ChemistryporSupramolecular hydrogels are highly promising for biomedical materials owing to the wide array of properties that can be tailored and modulated. The combination with plasmonic/magnetic nanoparticles into plasmonic magnetogels further improve its potential in biomedical applications, through the combination of complementary strategies, such as photothermia, magnetic hyperthermia, photodynamic therapy and magnetic-guided drug delivery. Here, a new dehydropeptide hydrogelator, Npx-L-Met-Z-ΔPhe-OH, was developed and combined with two different plasmonic/magnetic nanoparticles architectures: core/shell manganese ferrite/gold nanoparticles or gold-decorated manganese ferrite nanoparticles with ca. 55 nm and 45 nm size, respectively. The characterization of magnetogels were performed by HR-TEM, FTIR, circular dichorism and rheological assays. The gels were tested as nanocarriers for a model antitumor drug, the natural compound curcumin. The incorporation of the drug in magnetogel matrices was confirmed through fluorescence-based techniques (FRET, fluorescence anisotropy and quenching). The curcumin release profiles were studied with and without excitation of the gold plasmon band. The transport of curcumin from magnetogels towards biomembrane models (small unilamellar vesicles) was assessed by FRET between the fluorescent drug and the lipid probe Nile Red. The developed magnetogels showed promising results for photothermia and photo-triggered drug release. The magnetogels bearing gold-decorated nanoparticles showed the best photothermia properties, while the ones containing core/shell nanoparticles had the best photoinduced curcumin release.application/pdfapplication/pdfporDehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapyVeloso, Sérgio Rafael SilvaMartins, J. A. R.Hilliou, L.Amorim, C. O.Amaral, V. S.Almeida, B. G.Jervis, Peter JohnMoreira, R.Pereira, D. M.Coutinho, Paulo J. G.Ferreira, Paula M. T.Castanheira, Elisabete M. S.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf2050-7518DOIIsPartOf10.1039/C9TB01900F2020-11-11T07:00:16Z20202020-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/62170http://purl.org/coar/access_right/c_abf2open accessmagnetic/plasmonic nanoparticlesmagnetogelsphotothermiacurcumincancer therapy4290398 bytes3109503 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020http://creativecommons.org/licenses/by-nc/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/8a33961c-bdc3-4dab-ace6-59386dddc57b/downloadhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/8f46de63-13a2-4f0b-8122-87cc36862482/download |
| spellingShingle | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy Veloso, Sérgio Rafael Silva magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| subject.fl_str_mv | magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| title | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| title_full | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| title_fullStr | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| title_full_unstemmed | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| title_short | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| title_sort | Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy |
| topic | magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| topic_facet | magnetic/plasmonic nanoparticles magnetogels photothermia curcumin cancer therapy |
| url | https://hdl.handle.net/1822/62170 |
| visible | 1 |