Publicação

How accurate is cytological diagnosis of cervical glandular lesions?

Ver documento

Detalhes bibliográficos
Resumo:Gynecological cytology has some inaccurate morphological categorization and poor interobserver reproducibility especially for glandular lesions. Liquid-based cytology (LBC) preparations are presumed to reduce artifacts that interfere in diagnosis performance, but its value to correctly identify glandular alterations has not been sufficiently reported. The objective of this study was to compare the diagnostic performance and interobserver agreement of LBC and conventional Pap smear to identify histologically confirmed glandular lesions according to five cytologists. Sensitivity ranged from 55.8 to 73.1% and 32.7 to 48.1% for Pap smear and LBC, respectively. Specificity ranged from 66.1 to 87.1% and 69.4 to 94.4%, respectively. In general, agreement between pairs of cytologists was poor with kappa-values around 0.45. In conclusion, relying entirely on cervical cytology to rule out glandular lesions may be risky. The use of HPV DNA test alone or combined to screening glandular lesions may contribute to minimize the limitations of both conventional and LBC preparations to diagnose glandular abnormalities.
Autores principais:Moreira, Marise A. R.
Outros Autores:Longatto, Adhemar; Castelo, Adauto; de Barros, Maria Rita Evangelista; Silva, Ana Paula da; Thomann, Patrícia; Mattosinho de Castro Ferraz, Maria da Gloria; Dores, Gerson Botacini das
Assunto:Cervical Intraepithelial Neoplasia Cytological Techniques Female Humans Papanicolaou Test Reproducibility of Results Retrospective Studies Sensitivity and Specificity Uterine Cervical Neoplasms Vaginal Smears liquid-based cytology adenocarcinoma DNA-Citoliq
Ano:2008
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

Registos relacionados

Registos relacionados