Publicação
Tunable performance of manganese oxide nanostructures as MRI contrast agents
| Resumo: | The development of responsive magnetic resonance imaging contrast agents opens the door to a highly sensitive and specific diagnosis of altered physiological conditions. In this field, manganese dioxide (MnO2) is starting to be a leading contributor due to its susceptibility to conditions relevant to human diseased states, such as cancer. So far, the preclinical application of MnO2 has mainly been in the form of nanosheets, with enhancements of magnetic resonance imaging signals up to 50‐fold upon activation. Herein, we thoroughly investigate, through a simple reaction, a series of MnxOy samples and correlate their phase composition and structure/morphology to the performance as classic/responsive MRI contrast agents in response to redox changes. Signal enhancements as high as 140‐fold were obtained from MnO2 nano‐urchins, and their capability as responsive magnetic resonance imaging contrast agents was demonstrated in vitro. |
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| Autores principais: | Bañobre-Lopéz, M. |
| Outros Autores: | García-Hevia, Lorena; Cerqueira, M. F.; Rivadulla, F.; Gallo, J. |
| Assunto: | MnO2 Magnetic resonance Imaging contrast agents electron spin resonance spectroscopy imaging agents magnetic resonance imaging manganese dioxide nanostructures |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | The development of responsive magnetic resonance imaging contrast agents opens the door to a highly sensitive and specific diagnosis of altered physiological conditions. In this field, manganese dioxide (MnO2) is starting to be a leading contributor due to its susceptibility to conditions relevant to human diseased states, such as cancer. So far, the preclinical application of MnO2 has mainly been in the form of nanosheets, with enhancements of magnetic resonance imaging signals up to 50‐fold upon activation. Herein, we thoroughly investigate, through a simple reaction, a series of MnxOy samples and correlate their phase composition and structure/morphology to the performance as classic/responsive MRI contrast agents in response to redox changes. Signal enhancements as high as 140‐fold were obtained from MnO2 nano‐urchins, and their capability as responsive magnetic resonance imaging contrast agents was demonstrated in vitro. |
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