Publicação
Advances in Candida sp. Biofilm Mannans
| Resumo: | Candida species belong to the normal human microbiota and are commonly responsible for several clinical manifestations from mucocutaneous overgrowth to severe bloodstream infections. Candida albicans is the predominant species involved in disease conditions. Nevertheless, in the last decade, the number of infections due to non-albicans Candida (NAC) species has significantly increased. Candida species have several virulence factors, such as hyphal growth, secretion of hydrolases, and the ability to form biofilms. Biofilm formation is considered one of the main virulence factors of C. albicans. Biofilm production can occur on the host mucosa and on the surface of medical indwelling devices and includes a self-produced polymeric matrix that encloses fungal micro-colonies in a complex structure. The main components of the biofilm matrix are polysaccharides (e.g. B-1,3 glucans and mannans), but proteins, DNA and lipids (e.g. ergosterol) can also be found in variable amounts. In this chapter, we will discuss the role of mannans within Candida biofilms. Additionally, the role of Candida biofilms in fungal structure, pathogenesis, and resistance will also be addressed. |
|---|---|
| Autores principais: | Romo, Jesus A. |
| Outros Autores: | Rodrigues, Maria Elisa Costa; Fernandes, Liliana Sousa; Papp, Csaba; Gácser, Attila; Rodrigues, Célia Fortuna |
| Assunto: | Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438293619048448 |
|---|---|
| author | Romo, Jesus A. |
| author2 | Rodrigues, Maria Elisa Costa Fernandes, Liliana Sousa Papp, Csaba Gácser, Attila Rodrigues, Célia Fortuna |
| author2_role | author author author author author |
| author_facet | Romo, Jesus A. Rodrigues, Maria Elisa Costa Fernandes, Liliana Sousa Papp, Csaba Gácser, Attila Rodrigues, Célia Fortuna |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Romo, Jesus A.\"},{\"Person.name\":\"Rodrigues, Maria Elisa Costa\"},{\"Person.name\":\"Fernandes, Liliana Sousa\"},{\"Person.name\":\"Papp, Csaba\"},{\"Person.name\":\"Gácser, Attila\"},{\"Person.name\":\"Rodrigues, Célia Fortuna\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Romo, Jesus A. Rodrigues, Maria Elisa Costa Fernandes, Liliana Sousa Papp, Csaba Gácser, Attila Rodrigues, Célia Fortuna |
| datacite.date.Accepted.fl_str_mv | 2019-08-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-04-05T09:37:33Z |
| datacite.date.embargoed.fl_str_mv | 2022-04-05T09:37:33Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| datacite.titles.title.fl_str_mv | Advances in Candida sp. Biofilm Mannans |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Romo, Jesus A. Rodrigues, Maria Elisa Costa Fernandes, Liliana Sousa Papp, Csaba Gácser, Attila Rodrigues, Célia Fortuna |
| dc.date.Accepted.fl_str_mv | 2019-08-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-04-05T09:37:33Z |
| dc.date.embargoed.fl_str_mv | 2022-04-05T09:37:33Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/76772 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Nova Science Publishers |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| dc.title.fl_str_mv | Advances in Candida sp. Biofilm Mannans |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_3248 |
| description | Candida species belong to the normal human microbiota and are commonly responsible for several clinical manifestations from mucocutaneous overgrowth to severe bloodstream infections. Candida albicans is the predominant species involved in disease conditions. Nevertheless, in the last decade, the number of infections due to non-albicans Candida (NAC) species has significantly increased. Candida species have several virulence factors, such as hyphal growth, secretion of hydrolases, and the ability to form biofilms. Biofilm formation is considered one of the main virulence factors of C. albicans. Biofilm production can occur on the host mucosa and on the surface of medical indwelling devices and includes a self-produced polymeric matrix that encloses fungal micro-colonies in a complex structure. The main components of the biofilm matrix are polysaccharides (e.g. B-1,3 glucans and mannans), but proteins, DNA and lipids (e.g. ergosterol) can also be found in variable amounts. In this chapter, we will discuss the role of mannans within Candida biofilms. Additionally, the role of Candida biofilms in fungal structure, pathogenesis, and resistance will also be addressed. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | bookPart |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/e24758fe-edee-4f41-9261-1e84048a9f08/download |
| id | rum_99129f342eaffcbf9bbc37ae93ff0e86 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/76772 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/76772 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Romo, Jesus A. Rodrigues, Maria Elisa Costa Fernandes, Liliana Sousa Papp, Csaba Gácser, Attila Rodrigues, Célia Fortuna |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Nova Science Publishers |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engNova Science PublishersporCandida species belong to the normal human microbiota and are commonly responsible for several clinical manifestations from mucocutaneous overgrowth to severe bloodstream infections. Candida albicans is the predominant species involved in disease conditions. Nevertheless, in the last decade, the number of infections due to non-albicans Candida (NAC) species has significantly increased. Candida species have several virulence factors, such as hyphal growth, secretion of hydrolases, and the ability to form biofilms. Biofilm formation is considered one of the main virulence factors of C. albicans. Biofilm production can occur on the host mucosa and on the surface of medical indwelling devices and includes a self-produced polymeric matrix that encloses fungal micro-colonies in a complex structure. The main components of the biofilm matrix are polysaccharides (e.g. B-1,3 glucans and mannans), but proteins, DNA and lipids (e.g. ergosterol) can also be found in variable amounts. In this chapter, we will discuss the role of mannans within Candida biofilms. Additionally, the role of Candida biofilms in fungal structure, pathogenesis, and resistance will also be addressed.application/pdfporAdvances in Candida sp. Biofilm MannansRomo, Jesus A.Rodrigues, Maria Elisa CostaFernandes, Liliana SousaPapp, CsabaGácser, AttilaRodrigues, Célia FortunaHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONRomo, Jesus A.; Rodrigues, M. Elisa; Fernandes, L.; Papp, Csaba; Gácser, Attila; Rodrigues, Célia F., Advances in Candida sp. Biofilm Mannans. In Leon V. Berhardt, Advances in Medicine and Biology, Vol. 151(3), Nova Science Publishers, 2019. ISBN: 978-1-53616-352-0, 99-128ISBNIsPartOf978-1-53616-352-02022-04-05T09:37:33Z2019-082022-04-04T16:18:40Z2019-08-01T00:00:00ZHandlehttps://hdl.handle.net/1822/76772http://purl.org/coar/access_right/c_abf2open accessCandidaMannanB-1,3 glucansBiofilmMatrixPathogenesisCell wallNAC714126 bytesliteraturehttp://purl.org/coar/resource_type/c_3248book parthttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/e24758fe-edee-4f41-9261-1e84048a9f08/download |
| spellingShingle | Advances in Candida sp. Biofilm Mannans Romo, Jesus A. Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| status | SINGLETON |
| subject.fl_str_mv | Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| title | Advances in Candida sp. Biofilm Mannans |
| title_full | Advances in Candida sp. Biofilm Mannans |
| title_fullStr | Advances in Candida sp. Biofilm Mannans |
| title_full_unstemmed | Advances in Candida sp. Biofilm Mannans |
| title_short | Advances in Candida sp. Biofilm Mannans |
| title_sort | Advances in Candida sp. Biofilm Mannans |
| topic | Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| topic_facet | Candida Mannan B-1,3 glucans Biofilm Matrix Pathogenesis Cell wall NAC |
| url | https://hdl.handle.net/1822/76772 |
| visible | 1 |