Publicação
The skin microbiome of infected pressure ulcers: a review and implications for health professionals
| Resumo: | Background Pressure ulcers (PUs) are injuries resulting from ischemia caused by prolonged compression or shear forces on the skin, adjacent tissues, and bones. Advanced stages of PUs are associated with infectious complications and constitute a major clinical challenge, with high social and economic impacts in health care. Goals This study aims to identify and describe the relationship between PUs risk factors, stages, and anatomical locations, and the relevance of microbial cohabitation and biofilm growth. Methods The narrative review method to advocating a critical and objective analysis of the current knowledge on the topic was performed. Indexed databases and direct consultation to specialized and high-impact journals on the subject were used to extract relevant information, guided by co-authors. The Medical Subject Heading of pressure ulcer (or injury), biofilms, infection, and other analogues terms were used. Results Development of PUs and consequent infection depend on several direct and indirect risk factors, including cutaneous/PUs microbiome, microclimate, and behavioral factors. Infected PUs are polymicrobial and characterized by biofilm-associated infection, phenotypic hypervariability of species, and inherent resistance to antimicrobials. The different stages and anatomical locations also play an important role in their colonization. The prevention and monitoring of PUs remain crucial for avoiding the emergence of systemic infections and reducing healthcare-associated costs, improve the quality of life of patients, and reduce de mortality-associated infected PUs. |
|---|---|
| Autores principais: | Gomes, Fernanda Isabel |
| Outros Autores: | Furtado, Guilherme Eustáquio; Henriques, Mariana; Baptista Sousa, Liliana; Santos-Costa, Paulo; Bernardes, Rafael; Apóstolo, João; Parreira, Pedro; Salgueiro-Oliveira, Anabela |
| Assunto: | Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438272459833344 |
|---|---|
| author | Gomes, Fernanda Isabel |
| author2 | Furtado, Guilherme Eustáquio Henriques, Mariana Baptista Sousa, Liliana Santos-Costa, Paulo Bernardes, Rafael Apóstolo, João Parreira, Pedro Salgueiro-Oliveira, Anabela |
| author2_role | author author author author author author author author |
| author_facet | Gomes, Fernanda Isabel Furtado, Guilherme Eustáquio Henriques, Mariana Baptista Sousa, Liliana Santos-Costa, Paulo Bernardes, Rafael Apóstolo, João Parreira, Pedro Salgueiro-Oliveira, Anabela |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gomes, Fernanda Isabel\"},{\"Person.name\":\"Furtado, Guilherme Eustáquio\"},{\"Person.name\":\"Henriques, Mariana\"},{\"Person.name\":\"Baptista Sousa, Liliana\"},{\"Person.name\":\"Santos-Costa, Paulo\"},{\"Person.name\":\"Bernardes, Rafael\"},{\"Person.name\":\"Apóstolo, João\"},{\"Person.name\":\"Parreira, Pedro\"},{\"Person.name\":\"Salgueiro-Oliveira, Anabela\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Gomes, Fernanda Isabel Furtado, Guilherme Eustáquio Henriques, Mariana Baptista Sousa, Liliana Santos-Costa, Paulo Bernardes, Rafael Apóstolo, João Parreira, Pedro Salgueiro-Oliveira, Anabela |
| datacite.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| datacite.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| datacite.titles.title.fl_str_mv | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Gomes, Fernanda Isabel Furtado, Guilherme Eustáquio Henriques, Mariana Baptista Sousa, Liliana Santos-Costa, Paulo Bernardes, Rafael Apóstolo, João Parreira, Pedro Salgueiro-Oliveira, Anabela |
| dc.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| dc.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/75120 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley-Blackwell |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| dc.title.fl_str_mv | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background Pressure ulcers (PUs) are injuries resulting from ischemia caused by prolonged compression or shear forces on the skin, adjacent tissues, and bones. Advanced stages of PUs are associated with infectious complications and constitute a major clinical challenge, with high social and economic impacts in health care. Goals This study aims to identify and describe the relationship between PUs risk factors, stages, and anatomical locations, and the relevance of microbial cohabitation and biofilm growth. Methods The narrative review method to advocating a critical and objective analysis of the current knowledge on the topic was performed. Indexed databases and direct consultation to specialized and high-impact journals on the subject were used to extract relevant information, guided by co-authors. The Medical Subject Heading of pressure ulcer (or injury), biofilms, infection, and other analogues terms were used. Results Development of PUs and consequent infection depend on several direct and indirect risk factors, including cutaneous/PUs microbiome, microclimate, and behavioral factors. Infected PUs are polymicrobial and characterized by biofilm-associated infection, phenotypic hypervariability of species, and inherent resistance to antimicrobials. The different stages and anatomical locations also play an important role in their colonization. The prevention and monitoring of PUs remain crucial for avoiding the emergence of systemic infections and reducing healthcare-associated costs, improve the quality of life of patients, and reduce de mortality-associated infected PUs. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/c305b0bf-cbec-423c-abe9-0fb0df25b767/download |
| id | rum_9c0aba61ba108350f91beef8aee1bec8 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/75120 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/75120 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Gomes, Fernanda Isabel Furtado, Guilherme Eustáquio Henriques, Mariana Baptista Sousa, Liliana Santos-Costa, Paulo Bernardes, Rafael Apóstolo, João Parreira, Pedro Salgueiro-Oliveira, Anabela |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Wiley-Blackwell |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWiley-BlackwellporBackground Pressure ulcers (PUs) are injuries resulting from ischemia caused by prolonged compression or shear forces on the skin, adjacent tissues, and bones. Advanced stages of PUs are associated with infectious complications and constitute a major clinical challenge, with high social and economic impacts in health care. Goals This study aims to identify and describe the relationship between PUs risk factors, stages, and anatomical locations, and the relevance of microbial cohabitation and biofilm growth. Methods The narrative review method to advocating a critical and objective analysis of the current knowledge on the topic was performed. Indexed databases and direct consultation to specialized and high-impact journals on the subject were used to extract relevant information, guided by co-authors. The Medical Subject Heading of pressure ulcer (or injury), biofilms, infection, and other analogues terms were used. Results Development of PUs and consequent infection depend on several direct and indirect risk factors, including cutaneous/PUs microbiome, microclimate, and behavioral factors. Infected PUs are polymicrobial and characterized by biofilm-associated infection, phenotypic hypervariability of species, and inherent resistance to antimicrobials. The different stages and anatomical locations also play an important role in their colonization. The prevention and monitoring of PUs remain crucial for avoiding the emergence of systemic infections and reducing healthcare-associated costs, improve the quality of life of patients, and reduce de mortality-associated infected PUs.application/pdfporThe skin microbiome of infected pressure ulcers: a review and implications for health professionalsGomes, Fernanda IsabelFurtado, Guilherme EustáquioHenriques, MarianaBaptista Sousa, LilianaSantos-Costa, PauloBernardes, RafaelApóstolo, JoãoParreira, PedroSalgueiro-Oliveira, AnabelaHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONGomes, Fernanda Isabel; Furtado, Guilherme Eustáquio; Henriques, Mariana; Baptista Sousa, Liliana; Santos-Costa, Paulo; Bernardes, Rafael; Apóstolo, João; Parreira, Pedro; Salgueiro-Oliveira, Anabela, The skin microbiome of infected pressure ulcers: a review and implications for health professionals. European Journal of Clinical Investigation, 52(1), e13688, 2022PMID34601718ARTICLENUMBERe13688ISSNIsPartOf0014-2972DOIIsPartOf10.1111/eci.1368820222022-01-02T18:13:36Z10000-01-01T00:00:00Z2022-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/75120http://purl.org/coar/access_right/c_16ecrestricted accessBiofilmsCoinfectionMicrobiotaPathogenic agentsPressure ulcerSkin diseases16547169 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_f1cfapplication/pdffulltexthttps://repositorium.uminho.pt/bitstreams/c305b0bf-cbec-423c-abe9-0fb0df25b767/download |
| spellingShingle | The skin microbiome of infected pressure ulcers: a review and implications for health professionals Gomes, Fernanda Isabel Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| status | SINGLETON |
| subject.fl_str_mv | Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| title | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| title_full | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| title_fullStr | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| title_full_unstemmed | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| title_short | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| title_sort | The skin microbiome of infected pressure ulcers: a review and implications for health professionals |
| topic | Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| topic_facet | Biofilms Coinfection Microbiota Pathogenic agents Pressure ulcer Skin diseases |
| url | https://hdl.handle.net/1822/75120 |
| visible | 1 |