Publicação
Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer
| Resumo: | The use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the developed products. Sunscreen formulations composed of HERP in different concentrations (1.5, 2.5 or 3.5% w/w) alone or in combination with a chemical (octyl methoxycinnamate) and/or physical (titanium dioxide) filters were developed using poloxamer 407 as gel basis. The preliminary and accelerated stability tests, texture analysis and spreadability tests were performed. All formulations revealed to be stable in preliminary stability assessment. The formulations containing HERP 1.5 and 2.5% alone or associated with the filters showed intense modifications during accelerated stability test, which were confirmed by rheological analyses. The incorporation of HERP and filters in the poloxamer hydrogel decreased the toughness of product (p<0.05) and the formulation containing HERP alone presented the lowest adhesivity (p<0.001). The incorporation of HERP in the hydrogel decreased the poloxamer transition temperature, showing different rheological behavior with the increase of HERP concentration. The developed formulations were stable, exhibited non-Newtonian and pseudoplastic behavior, showing in vivo skin compatibility and no skin irritancy. |
|---|---|
| Autores principais: | Batista, Cinthia M. |
| Outros Autores: | Queiroz, Luma A. de; Alves, Ângela V. F.; Reis, Elisiane C. A.; Santos, Fagne A.; Castro, Tailaine N.; Lima, Bruno S.; Araújo, Adriano N. S.; Godoy, Charles A. P.; Severino, Patricia; Cano, Amanda; Santini, Antonello; Capasso, Raffaele; Júnior, Ricardo L. C. de Albuquerque; Cardoso, Juliana C.; Souto, Eliana B. |
| Assunto: | Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866270809882886144 |
|---|---|
| author | Batista, Cinthia M. |
| author2 | Queiroz, Luma A. de Alves, Ângela V. F. Reis, Elisiane C. A. Santos, Fagne A. Castro, Tailaine N. Lima, Bruno S. Araújo, Adriano N. S. Godoy, Charles A. P. Severino, Patricia Cano, Amanda Santini, Antonello Capasso, Raffaele Júnior, Ricardo L. C. de Albuquerque Cardoso, Juliana C. Souto, Eliana B. |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Batista, Cinthia M. Queiroz, Luma A. de Alves, Ângela V. F. Reis, Elisiane C. A. Santos, Fagne A. Castro, Tailaine N. Lima, Bruno S. Araújo, Adriano N. S. Godoy, Charles A. P. Severino, Patricia Cano, Amanda Santini, Antonello Capasso, Raffaele Júnior, Ricardo L. C. de Albuquerque Cardoso, Juliana C. Souto, Eliana B. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Batista, Cinthia M.\"},{\"Person.name\":\"Queiroz, Luma A. de\"},{\"Person.name\":\"Alves, Ângela V. F.\"},{\"Person.name\":\"Reis, Elisiane C. A.\"},{\"Person.name\":\"Santos, Fagne A.\"},{\"Person.name\":\"Castro, Tailaine N.\"},{\"Person.name\":\"Lima, Bruno S.\"},{\"Person.name\":\"Araújo, Adriano N. S.\"},{\"Person.name\":\"Godoy, Charles A. P.\"},{\"Person.name\":\"Severino, Patricia\"},{\"Person.name\":\"Cano, Amanda\"},{\"Person.name\":\"Santini, Antonello\"},{\"Person.name\":\"Capasso, Raffaele\"},{\"Person.name\":\"Júnior, Ricardo L. C. de Albuquerque\"},{\"Person.name\":\"Cardoso, Juliana C.\"},{\"Person.name\":\"Souto, Eliana B.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Batista, Cinthia M. Queiroz, Luma A. de Alves, Ângela V. F. Reis, Elisiane C. A. Santos, Fagne A. Castro, Tailaine N. Lima, Bruno S. Araújo, Adriano N. S. Godoy, Charles A. P. Severino, Patricia Cano, Amanda Santini, Antonello Capasso, Raffaele Júnior, Ricardo L. C. de Albuquerque Cardoso, Juliana C. Souto, Eliana B. |
| datacite.date.Accepted.fl_str_mv | 2022-02-03T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-04-19T11:16:15Z |
| datacite.date.embargoed.fl_str_mv | 2022-04-19T11:16:15Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| datacite.titles.title.fl_str_mv | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Batista, Cinthia M. Queiroz, Luma A. de Alves, Ângela V. F. Reis, Elisiane C. A. Santos, Fagne A. Castro, Tailaine N. Lima, Bruno S. Araújo, Adriano N. S. Godoy, Charles A. P. Severino, Patricia Cano, Amanda Santini, Antonello Capasso, Raffaele Júnior, Ricardo L. C. de Albuquerque Cardoso, Juliana C. Souto, Eliana B. |
| dc.date.Accepted.fl_str_mv | 2022-02-03T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-04-19T11:16:15Z |
| dc.date.embargoed.fl_str_mv | 2022-04-19T11:16:15Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/76993 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| dc.title.fl_str_mv | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the developed products. Sunscreen formulations composed of HERP in different concentrations (1.5, 2.5 or 3.5% w/w) alone or in combination with a chemical (octyl methoxycinnamate) and/or physical (titanium dioxide) filters were developed using poloxamer 407 as gel basis. The preliminary and accelerated stability tests, texture analysis and spreadability tests were performed. All formulations revealed to be stable in preliminary stability assessment. The formulations containing HERP 1.5 and 2.5% alone or associated with the filters showed intense modifications during accelerated stability test, which were confirmed by rheological analyses. The incorporation of HERP and filters in the poloxamer hydrogel decreased the toughness of product (p<0.05) and the formulation containing HERP alone presented the lowest adhesivity (p<0.001). The incorporation of HERP in the hydrogel decreased the poloxamer transition temperature, showing different rheological behavior with the increase of HERP concentration. The developed formulations were stable, exhibited non-Newtonian and pseudoplastic behavior, showing in vivo skin compatibility and no skin irritancy. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/b569ce40-ea13-4c02-bef0-f679632ea602/download |
| id | rum_9c417b37e53bd213cbd552b59a3fbfbb |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/76993 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/76993 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Batista, Cinthia M. Queiroz, Luma A. de Alves, Ângela V. F. Reis, Elisiane C. A. Santos, Fagne A. Castro, Tailaine N. Lima, Bruno S. Araújo, Adriano N. S. Godoy, Charles A. P. Severino, Patricia Cano, Amanda Santini, Antonello Capasso, Raffaele Júnior, Ricardo L. C. de Albuquerque Cardoso, Juliana C. Souto, Eliana B. |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engElsevierporThe use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the developed products. Sunscreen formulations composed of HERP in different concentrations (1.5, 2.5 or 3.5% w/w) alone or in combination with a chemical (octyl methoxycinnamate) and/or physical (titanium dioxide) filters were developed using poloxamer 407 as gel basis. The preliminary and accelerated stability tests, texture analysis and spreadability tests were performed. All formulations revealed to be stable in preliminary stability assessment. The formulations containing HERP 1.5 and 2.5% alone or associated with the filters showed intense modifications during accelerated stability test, which were confirmed by rheological analyses. The incorporation of HERP and filters in the poloxamer hydrogel decreased the toughness of product (p<0.05) and the formulation containing HERP alone presented the lowest adhesivity (p<0.001). The incorporation of HERP in the hydrogel decreased the poloxamer transition temperature, showing different rheological behavior with the increase of HERP concentration. The developed formulations were stable, exhibited non-Newtonian and pseudoplastic behavior, showing in vivo skin compatibility and no skin irritancy.application/pdfporPhotoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancerBatista, Cinthia M.Queiroz, Luma A. deAlves, Ângela V. F.Reis, Elisiane C. A.Santos, Fagne A.Castro, Tailaine N.Lima, Bruno S.Araújo, Adriano N. S.Godoy, Charles A. P.Severino, PatriciaCano, AmandaSantini, AntonelloCapasso, RaffaeleJúnior, Ricardo L. C. de AlbuquerqueCardoso, Juliana C.Souto, Eliana B.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf2405-8440DOIIsPartOf10.1016/j.heliyon.2022.e088932022-04-19T11:16:15Z2022-02-032022-02-19T10:39:01Z2022-02-03T00:00:00ZHandlehttps://hdl.handle.net/1822/76993http://purl.org/coar/access_right/c_abf2open accessRed propolisPhotoprotectionHydrogelsPoloxamerSunscreen1264036 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/b569ce40-ea13-4c02-bef0-f679632ea602/download |
| spellingShingle | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer Batista, Cinthia M. Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| status | SINGLETON |
| subject.fl_str_mv | Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| title | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| title_full | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| title_fullStr | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| title_full_unstemmed | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| title_short | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| title_sort | Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer |
| topic | Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| topic_facet | Red propolis Photoprotection Hydrogels Poloxamer Sunscreen |
| url | https://hdl.handle.net/1822/76993 |
| visible | 1 |