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Do stars govern our actions? astrocyte involvement in rodent behavior

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Detalhes bibliográficos
Resumo:Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron–astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.
Autores principais:Oliveira, João F.
Outros Autores:Sardinha, Vanessa Morais; Gomes, Sónia Isabel Nunes Guerra; Araque, Alfonso; Sousa, Nuno
Assunto:astrocyte behavior cognition emotion motor sensorial
Ano:2015
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron–astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.