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Development of poly(vinylidene fluoride)/ionic liquid electrospun fibers for tissue engineering applications

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Resumo:Electroactive electrospun fiber mat composites based on poly (vinylidene fluoride) (PVDF) with 5 and 10% of 1-ethyl-3-methylimidazolium bis (trifluoromethanesulfonyl)amide ([C2mim][NTf2]) ionic liquid (IL) were developed for potential applications in the biomedical area. The morphology and polymer crystalline phase content of the fibers were evaluated as a function of the processing conditions. Hydrophobic random and aligned fibers have been obtained with average fiber diameters between ~700 and 500 nm, the smaller diameters corresponding to the aligned fiber mats. The results show that the charge structure of [C2mim][NTf2] induces the crystallization of the PVDF fibers in the piezoelectric B-phase with full crystallization in this phase for an ionic liquid content of 10 wt%. Furthermore, the presence of the ionic liquid also increases the degree of crystallinity of the fibers. Thermal degradation studies show a single degradation process which is strongly influenced by the polymer-IL interactions. Finally, the non-cytotoxicity of the fiber mats indicates their suitability for biomedical applications.
Autores principais:Dias, Juliana C.
Outros Autores:Correia, D. C.; Lopes, Ana C.; Ribeiro, Sylvie Oliveira; Ribeiro, Clarisse; Sencadas, Vítor João Gomes Silva; Botelho, Gabriela; Esperança, J. M. S. S.; Laza, José M.; Vilas, José L.; León, Luis M.; Lanceros-Méndez, S.
Assunto:Electroactive polymers Smart materials Electrospun fibers, Thermal degradation kinetics Tissue engineering applications
Ano:2016
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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