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Tau protein is essential for stress-induced brain pathology

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Resumo:Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyper-phosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of Tau and enhanced Fyn/GluN2B-driven synaptic signaling. In contrast, mice lacking Tau [Tau knockout (Tau-KO) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. These findings implicate Tau as an essential mediator of the adverse effects of stress on brain structure and function.
Autores principais:Lopes, Sofia
Outros Autores:Silva, João Vaz; Pinto, Vítor; Dalla, Christina; Kokras, N.; Bedenk, Benedikt; Mack, Natalie; Czisch, Michael; Almeida, Osborne F. X.; Sousa, Nuno; Sotiropoulos, Ioannis
Assunto:Tau Stress Hippocampus Depression Memory deficits Emory deficits
Ano:2016
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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