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Antimicrobial enzyme immobilization in bacterial cellulose

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Resumo:This work studied the physical immobilization of laccase on bacterial nanocellulose (BNC) aiming to identify the enzyme antibacterial properties suitable for wound dressings. The pH optimum and activation energy of free laccase depends on the substrate employed. The Michaelis-Menten constant for the immobilized laccase was found to be almost double of that of the free enzyme. However, the specific activities of immobilized and free laccase are similar suggesting that entrapped laccase on BNC maintain some flexibility and favour substrate accessibility. The results clearly show the antimicrobial effect of laccase and cytotoxicity acceptable for wound dressing applications.
Autores principais:Sampaio, Liliana M. P.
Outros Autores:Ribeiro, Jorge Manuel Padrão; Faria, Jorge; Silva, João Pedro Martins Soares Castro; Silva, Carla J.; Dourado, Fernando; Zille, Andrea
Assunto:Bacterial nanocellulose Laccase Antimicrobial Immobilization
Ano:2017
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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