Publicação
IRAK4 gene polymorphism and odontogenic maxillary sinusitis
| Resumo: | Objectives This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin.Materials and methods The study population included 153 Portuguese Caucasians that were selected from a database of 504 retrospectively analysed computed tomography (CT) scans. A genetic test was performed, and a model was created through logistic analysis and regression coefficients. The statistical methodologies included were the independent Chi test, Fisher's exact test, binary logistic regression and the receiver operating characteristic (ROC) curve.Results The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95 %) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed. This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.Conclusions The constructed model should be considered an initial clinical tool. The area under the ROC curve found, AUC=0.91, revealed that the model correctly predicts the outcome in 91.1 % of cases. |
|---|---|
| Autores principais: | Pereira, Ines Guerra |
| Outros Autores: | Vaz, Paula; Almeida, Ricardo Faria; Braga, A. C.; Felino, Antonio |
| Assunto: | Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866878198443147264 |
|---|---|
| author | Pereira, Ines Guerra |
| author2 | Vaz, Paula Almeida, Ricardo Faria Braga, A. C. Felino, Antonio |
| author2_role | author author author author |
| author_facet | Pereira, Ines Guerra Vaz, Paula Almeida, Ricardo Faria Braga, A. C. Felino, Antonio |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pereira, Ines Guerra\"},{\"Person.name\":\"Vaz, Paula\"},{\"Person.name\":\"Almeida, Ricardo Faria\"},{\"Person.name\":\"Braga, A. C.\"},{\"Person.name\":\"Felino, Antonio\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Pereira, Ines Guerra Vaz, Paula Almeida, Ricardo Faria Braga, A. C. Felino, Antonio |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-03-19T11:45:52Z |
| datacite.date.embargoed.fl_str_mv | 2018-03-19T11:45:52Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| datacite.titles.title.fl_str_mv | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Pereira, Ines Guerra Vaz, Paula Almeida, Ricardo Faria Braga, A. C. Felino, Antonio |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-03-19T11:45:52Z |
| dc.date.embargoed.fl_str_mv | 2018-03-19T11:45:52Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/52771 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer Heidelberg |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| dc.title.fl_str_mv | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Objectives This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin.Materials and methods The study population included 153 Portuguese Caucasians that were selected from a database of 504 retrospectively analysed computed tomography (CT) scans. A genetic test was performed, and a model was created through logistic analysis and regression coefficients. The statistical methodologies included were the independent Chi test, Fisher's exact test, binary logistic regression and the receiver operating characteristic (ROC) curve.Results The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95 %) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed. This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.Conclusions The constructed model should be considered an initial clinical tool. The area under the ROC curve found, AUC=0.91, revealed that the model correctly predicts the outcome in 91.1 % of cases. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/408e8472-2fc2-4cb6-802a-31f8e8df5449/download |
| id | rum_b0dd69b2db51b320bb6d05ab9c3b37f6 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/52771 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/52771 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Pereira, Ines Guerra Vaz, Paula Almeida, Ricardo Faria Braga, A. C. Felino, Antonio |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Springer Heidelberg |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engSpringer HeidelbergporObjectives This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin.Materials and methods The study population included 153 Portuguese Caucasians that were selected from a database of 504 retrospectively analysed computed tomography (CT) scans. A genetic test was performed, and a model was created through logistic analysis and regression coefficients. The statistical methodologies included were the independent Chi test, Fisher's exact test, binary logistic regression and the receiver operating characteristic (ROC) curve.Results The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95 %) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed. This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.Conclusions The constructed model should be considered an initial clinical tool. The area under the ROC curve found, AUC=0.91, revealed that the model correctly predicts the outcome in 91.1 % of cases.application/pdfporIRAK4 gene polymorphism and odontogenic maxillary sinusitisPereira, Ines GuerraVaz, PaulaAlmeida, Ricardo FariaBraga, A. C.Felino, AntonioHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1432-6981DOIIsPartOf10.1007/s00784-015-1424-52018-03-19T11:45:52Z20152018-03-14T17:05:42Z2015-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/52771http://purl.org/coar/access_right/c_abf2open accessGenetic polymorphismMaxillary sinusitisIRAK-4 human proteinGenetic predisposition539264 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/408e8472-2fc2-4cb6-802a-31f8e8df5449/download |
| spellingShingle | IRAK4 gene polymorphism and odontogenic maxillary sinusitis Pereira, Ines Guerra Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| status | SINGLETON |
| subject.fl_str_mv | Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| title | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| title_full | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| title_fullStr | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| title_full_unstemmed | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| title_short | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| title_sort | IRAK4 gene polymorphism and odontogenic maxillary sinusitis |
| topic | Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| topic_facet | Genetic polymorphism Maxillary sinusitis IRAK-4 human protein Genetic predisposition |
| url | https://hdl.handle.net/1822/52771 |
| visible | 1 |