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Decreasing arterial aging by controlling blood pressure levels and hypertension: a step forward

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Resumo:Arterial aging, characterized by arterial stiffening that is clinically evaluable as aortic pulse wave velocity, is risky for CV events, disability, and loss of cognitive function. Today the only adopted strategy to decrease arterial aging/ arterial stiffness is represented by decreasing BP. Selective antihypertensive drug classes (calcium channel blockers, converting enzyme inhibitors, angiotensin type 1 receptor antagonists) showed a beneficial effect on the arterial wall and on both large and small arteries over and above the reduction in BP levels. Still, the lower the better paradigm seems only to expose older subjects to higher rate of side effects, that via hypotension result in even transient organ hypoperfusion. This vicious circle may be particularly detrimental for cerebral district and, thus, for cognitive impairment onset and progression until dementia.
Autores principais:Scuteri, Angelo
Outros Autores:Cunha, Pedro Guimarães
Assunto:Age Factors Antihypertensive Agents Blood Pressure Cerebrovascular Circulation Cognition Humans Hypertension Hypotension Risk Assessment Risk Factors Risk Reduction Behavior Treatment Outcome Vascular Stiffness Aging Arterial aging pulse wave velocity hypertension treatment cognitive impairment
Ano:2012
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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