Publicação
Hypericum perforatum and Its potential antiplatelet effect
| Resumo: | Background: <i>Hypericum perforatum</i> (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (<i>Guan Ye Lian Qiao</i>) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties. |
|---|---|
| Autores principais: | Monteiro, Maria-do-Céu |
| Outros Autores: | Dias, Alberto Carlos Pires; Costa, Daniela; Almeida-Dias, António; Criado, Maria Begoña |
| Assunto: | Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866875591548993536 |
|---|---|
| author | Monteiro, Maria-do-Céu |
| author2 | Dias, Alberto Carlos Pires Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
| author2_role | author author author author |
| author_facet | Monteiro, Maria-do-Céu Dias, Alberto Carlos Pires Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Monteiro, Maria-do-Céu\"},{\"Person.name\":\"Dias, Alberto Carlos Pires\"},{\"Person.name\":\"Costa, Daniela\"},{\"Person.name\":\"Almeida-Dias, António\"},{\"Person.name\":\"Criado, Maria Begoña\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Monteiro, Maria-do-Céu Dias, Alberto Carlos Pires Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
| datacite.date.Accepted.fl_str_mv | 2022-09-15T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-11-21T10:55:48Z |
| datacite.date.embargoed.fl_str_mv | 2022-11-21T10:55:48Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| datacite.titles.title.fl_str_mv | Hypericum perforatum and Its potential antiplatelet effect |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Monteiro, Maria-do-Céu Dias, Alberto Carlos Pires Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
| dc.date.Accepted.fl_str_mv | 2022-09-15T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-11-21T10:55:48Z |
| dc.date.embargoed.fl_str_mv | 2022-11-21T10:55:48Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/80744 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| dc.title.fl_str_mv | Hypericum perforatum and Its potential antiplatelet effect |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: <i>Hypericum perforatum</i> (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (<i>Guan Ye Lian Qiao</i>) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/a945f472-b04f-4af2-9556-8037b192e1a8/download |
| id | rum_b8c76ec39f623ca71bc3d2b41ba77bf3 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/80744 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/80744 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Monteiro, Maria-do-Céu Dias, Alberto Carlos Pires Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMultidisciplinary Digital Publishing InstituteporBackground: <i>Hypericum perforatum</i> (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (<i>Guan Ye Lian Qiao</i>) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties.application/pdfengHypericum perforatum and Its potential antiplatelet effectMonteiro, Maria-do-CéuDias, Alberto Carlos PiresCosta, DanielaAlmeida-Dias, AntónioCriado, Maria BegoñaHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptDOIIsPartOf10.3390/healthcare100917742022-11-21T10:55:48Z2022-09-152022-09-22T12:02:38Z2022-09-15T00:00:00ZHandlehttps://hdl.handle.net/1822/80744http://purl.org/coar/access_right/c_abf2open accessHypericum perforatumplatelet activationflow cytometrytraditional Chinesemedicinetraditional Chinese medicine1531829 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2022-09-15http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/a945f472-b04f-4af2-9556-8037b192e1a8/download |
| spellingShingle | Hypericum perforatum and Its potential antiplatelet effect Monteiro, Maria-do-Céu Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| status | SINGLETON |
| subject.fl_str_mv | Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| title | Hypericum perforatum and Its potential antiplatelet effect |
| title_full | Hypericum perforatum and Its potential antiplatelet effect |
| title_fullStr | Hypericum perforatum and Its potential antiplatelet effect |
| title_full_unstemmed | Hypericum perforatum and Its potential antiplatelet effect |
| title_short | Hypericum perforatum and Its potential antiplatelet effect |
| title_sort | Hypericum perforatum and Its potential antiplatelet effect |
| topic | Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| topic_facet | Hypericum perforatum platelet activation flow cytometry traditional Chinese medicine traditional Chinese medicine |
| url | https://hdl.handle.net/1822/80744 |
| visible | 1 |