Publication
Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study
| Summary: | Obsessive-compulsive personality (OCPD) disorder is characterized by a pattern of excessive self-control, perfectionism and behavioral and cognitive rigidity. Despite the fact that OCPD is the most common personality disorder in the general population, published studies looking at the brain correlates of this disorder are practically nonexistent. The main goal of this study was to analyze the presence of brain alterations in OCPD when compared to healthy controls, specifically at the level of the Default Mode Network (DMN). The DMN is a well-established resting state network which was found to be associated with psychological processes that may play a key role in OCPD (e.g., self-awareness, episodic future thinking and mental simulation). Ten individuals diagnosed with OCPD and ten healthy controls underwent a clinical assessment interview and a resting-state functional magnetic resonance imaging (fMRI) acquisition. The results show that OCPD patients presented an increased functional connectivity in the precuneus (i.e., a posterior node of the DMN), known to be involved in the retrieval manipulation of past events in order to solve current problems and develop plans for the future. These results suggest that this key node of the DMN may play an important role in the pathophysiology of OCPD. |
|---|---|
| Main Authors: | Coutinho, Joana Fernandes Pereira |
| Other Authors: | Gonçalves, Óscar F.; Soares, José Miguel Montenegro; Marques, Paulo César Gonçalves; Sampaio, Adriana |
| Subject: | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| Year: | 2016 |
| Country: | Portugal |
| Document type: | article |
| Access type: | restricted access |
| Associated institution: | Universidade do Minho |
| Language: | English |
| Origin: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438421729869824 |
|---|---|
| author | Coutinho, Joana Fernandes Pereira |
| author2 | Gonçalves, Óscar F. Soares, José Miguel Montenegro Marques, Paulo César Gonçalves Sampaio, Adriana |
| author2_role | author author author author |
| author_facet | Coutinho, Joana Fernandes Pereira Gonçalves, Óscar F. Soares, José Miguel Montenegro Marques, Paulo César Gonçalves Sampaio, Adriana |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Coutinho, Joana Fernandes Pereira\"},{\"Person.name\":\"Gonçalves, Óscar F.\"},{\"Person.name\":\"Soares, José Miguel Montenegro\"},{\"Person.name\":\"Marques, Paulo César Gonçalves\"},{\"Person.name\":\"Sampaio, Adriana\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Coutinho, Joana Fernandes Pereira Gonçalves, Óscar F. Soares, José Miguel Montenegro Marques, Paulo César Gonçalves Sampaio, Adriana |
| datacite.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| datacite.titles.title.fl_str_mv | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Coutinho, Joana Fernandes Pereira Gonçalves, Óscar F. Soares, José Miguel Montenegro Marques, Paulo César Gonçalves Sampaio, Adriana |
| dc.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/52216 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| dc.title.fl_str_mv | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Obsessive-compulsive personality (OCPD) disorder is characterized by a pattern of excessive self-control, perfectionism and behavioral and cognitive rigidity. Despite the fact that OCPD is the most common personality disorder in the general population, published studies looking at the brain correlates of this disorder are practically nonexistent. The main goal of this study was to analyze the presence of brain alterations in OCPD when compared to healthy controls, specifically at the level of the Default Mode Network (DMN). The DMN is a well-established resting state network which was found to be associated with psychological processes that may play a key role in OCPD (e.g., self-awareness, episodic future thinking and mental simulation). Ten individuals diagnosed with OCPD and ten healthy controls underwent a clinical assessment interview and a resting-state functional magnetic resonance imaging (fMRI) acquisition. The results show that OCPD patients presented an increased functional connectivity in the precuneus (i.e., a posterior node of the DMN), known to be involved in the retrieval manipulation of past events in order to solve current problems and develop plans for the future. These results suggest that this key node of the DMN may play an important role in the pathophysiology of OCPD. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/d6368486-a5a5-4bcd-b107-40c08ca4c9a2/download |
| id | rum_bbc8e7c8b88871bcaf39b7e8d977bb84 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/52216 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
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| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/52216 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Coutinho, Joana Fernandes Pereira Gonçalves, Óscar F. Soares, José Miguel Montenegro Marques, Paulo César Gonçalves Sampaio, Adriana |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
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| spelling | engElsevierporObsessive-compulsive personality (OCPD) disorder is characterized by a pattern of excessive self-control, perfectionism and behavioral and cognitive rigidity. Despite the fact that OCPD is the most common personality disorder in the general population, published studies looking at the brain correlates of this disorder are practically nonexistent. The main goal of this study was to analyze the presence of brain alterations in OCPD when compared to healthy controls, specifically at the level of the Default Mode Network (DMN). The DMN is a well-established resting state network which was found to be associated with psychological processes that may play a key role in OCPD (e.g., self-awareness, episodic future thinking and mental simulation). Ten individuals diagnosed with OCPD and ten healthy controls underwent a clinical assessment interview and a resting-state functional magnetic resonance imaging (fMRI) acquisition. The results show that OCPD patients presented an increased functional connectivity in the precuneus (i.e., a posterior node of the DMN), known to be involved in the retrieval manipulation of past events in order to solve current problems and develop plans for the future. These results suggest that this key node of the DMN may play an important role in the pathophysiology of OCPD.application/pdfporAlterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot studyCoutinho, Joana Fernandes PereiraGonçalves, Óscar F.Soares, José Miguel MontenegroMarques, Paulo César GonçalvesSampaio, AdrianaHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID27591486ISSNIsPartOf0925-4927DOIIsPartOf10.1016/j.pscychresns.2016.08.00720162018-02-26T16:25:06Z2016-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/52216http://purl.org/coar/access_right/c_16ecrestricted accessObsessive-compulsive personality disorderNeuroimagingFunctional MRIDefault-mode networkFunctional connectivity610091 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorium.uminho.pt/bitstreams/d6368486-a5a5-4bcd-b107-40c08ca4c9a2/download |
| spellingShingle | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study Coutinho, Joana Fernandes Pereira Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| status | SINGLETON |
| subject.fl_str_mv | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| title | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| title_full | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| title_fullStr | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| title_full_unstemmed | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| title_short | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| title_sort | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
| topic | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| topic_facet | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
| url | https://hdl.handle.net/1822/52216 |
| visible | 1 |