Publicação
Aptamer-based therapy for fighting biofilm-associated infections
| Resumo: | Biofilms are key players in the pathogenesis of most of chronic infections associated with host tissue or fluids and indwelling medical devices. These chronic infections are hard to be treated due to the increased biofilms tolerance towards antibiotics in comparison to planktonic (or free living) cells. Despite the advanced understanding of their formation and physiology, biofilms continue to be a challenge and there is no standardized therapeutic approach in clinical practice to eradicate them. Aptamers offer distinctive properties, including excellent affinity, selectivity, stability, making them valuable tools for therapeutic purposes. This review explores the flexibility and designability of aptamers as antibiofilm drugs but, importantly, as targeting tools for diverse drug and delivery systems. It highlights specific examples of application of aptamers in biofilms of diverse species according to different modes of action including inhibition of motility and adhesion, blocking of quorum sensing molecules, and dispersal of biofilm-cells to planktonic state. Moreover, it discusses the limitations and challenges that impaired an increased success of the use of aptamers on biofilm management, as well as the opportunities related to aptamers modifications that can significantly expand their applicability on the biofilm field. |
|---|---|
| Autores principais: | Sousa, Ana Margarida |
| Outros Autores: | Ferreira, Débora; Rodrigues, L. R.; Pereira, Maria Olívia |
| Assunto: | Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866875658355867648 |
|---|---|
| author | Sousa, Ana Margarida |
| author2 | Ferreira, Débora Rodrigues, L. R. Pereira, Maria Olívia |
| author2_role | author author author |
| author_facet | Sousa, Ana Margarida Ferreira, Débora Rodrigues, L. R. Pereira, Maria Olívia |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sousa, Ana Margarida\"},{\"Person.name\":\"Ferreira, Débora\"},{\"Person.name\":\"Rodrigues, L. R.\"},{\"Person.name\":\"Pereira, Maria Olívia\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Sousa, Ana Margarida Ferreira, Débora Rodrigues, L. R. Pereira, Maria Olívia |
| datacite.date.Accepted.fl_str_mv | 2024-03-01T00:00:00Z |
| datacite.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| datacite.titles.title.fl_str_mv | Aptamer-based therapy for fighting biofilm-associated infections |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Sousa, Ana Margarida Ferreira, Débora Rodrigues, L. R. Pereira, Maria Olívia |
| dc.date.Accepted.fl_str_mv | 2024-03-01T00:00:00Z |
| dc.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/88591 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.rights.rights.copyright.fl_str_mv | restrictedAccess |
| dc.subject.none.fl_str_mv | Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| dc.title.fl_str_mv | Aptamer-based therapy for fighting biofilm-associated infections |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Biofilms are key players in the pathogenesis of most of chronic infections associated with host tissue or fluids and indwelling medical devices. These chronic infections are hard to be treated due to the increased biofilms tolerance towards antibiotics in comparison to planktonic (or free living) cells. Despite the advanced understanding of their formation and physiology, biofilms continue to be a challenge and there is no standardized therapeutic approach in clinical practice to eradicate them. Aptamers offer distinctive properties, including excellent affinity, selectivity, stability, making them valuable tools for therapeutic purposes. This review explores the flexibility and designability of aptamers as antibiofilm drugs but, importantly, as targeting tools for diverse drug and delivery systems. It highlights specific examples of application of aptamers in biofilms of diverse species according to different modes of action including inhibition of motility and adhesion, blocking of quorum sensing molecules, and dispersal of biofilm-cells to planktonic state. Moreover, it discusses the limitations and challenges that impaired an increased success of the use of aptamers on biofilm management, as well as the opportunities related to aptamers modifications that can significantly expand their applicability on the biofilm field. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/4a81cf91-3b46-4829-b748-f3d8ea9bfdc4/download |
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| identifier.url.fl_str_mv | https://hdl.handle.net/1822/88591 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
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| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/88591 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Sousa, Ana Margarida Ferreira, Débora Rodrigues, L. R. Pereira, Maria Olívia |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engElsevierporBiofilms are key players in the pathogenesis of most of chronic infections associated with host tissue or fluids and indwelling medical devices. These chronic infections are hard to be treated due to the increased biofilms tolerance towards antibiotics in comparison to planktonic (or free living) cells. Despite the advanced understanding of their formation and physiology, biofilms continue to be a challenge and there is no standardized therapeutic approach in clinical practice to eradicate them. Aptamers offer distinctive properties, including excellent affinity, selectivity, stability, making them valuable tools for therapeutic purposes. This review explores the flexibility and designability of aptamers as antibiofilm drugs but, importantly, as targeting tools for diverse drug and delivery systems. It highlights specific examples of application of aptamers in biofilms of diverse species according to different modes of action including inhibition of motility and adhesion, blocking of quorum sensing molecules, and dispersal of biofilm-cells to planktonic state. Moreover, it discusses the limitations and challenges that impaired an increased success of the use of aptamers on biofilm management, as well as the opportunities related to aptamers modifications that can significantly expand their applicability on the biofilm field.application/pdfporAptamer-based therapy for fighting biofilm-associated infectionsSousa, Ana MargaridaFerreira, DéboraRodrigues, L. R.Pereira, Maria OlíviaHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf0168-3659DOIIsPartOf10.1016/j.jconrel.2024.01.0612024-032024-02-06T13:48:23Z2024-03-01T00:00:00Z10000-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/88591http://purl.org/coar/access_right/c_16ecrestricted accessAptamersAntibiofilm therapyBiofilm detectionBiofilm inhibitionBiofilm disassembly1763733 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2024-03http://creativecommons.org/licenses/by-nc/4.0/restrictedAccesshttp://purl.org/coar/access_right/c_f1cfapplication/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/4a81cf91-3b46-4829-b748-f3d8ea9bfdc4/download |
| spellingShingle | Aptamer-based therapy for fighting biofilm-associated infections Sousa, Ana Margarida Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| status | SINGLETON |
| subject.fl_str_mv | Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| title | Aptamer-based therapy for fighting biofilm-associated infections |
| title_full | Aptamer-based therapy for fighting biofilm-associated infections |
| title_fullStr | Aptamer-based therapy for fighting biofilm-associated infections |
| title_full_unstemmed | Aptamer-based therapy for fighting biofilm-associated infections |
| title_short | Aptamer-based therapy for fighting biofilm-associated infections |
| title_sort | Aptamer-based therapy for fighting biofilm-associated infections |
| topic | Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| topic_facet | Aptamers Antibiofilm therapy Biofilm detection Biofilm inhibition Biofilm disassembly |
| url | https://hdl.handle.net/1822/88591 |
| visible | 1 |