Publicação
A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis
| Resumo: | Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec = 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8(rs13266634) SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1B(rs7501939) SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men. |
|---|---|
| Autores principais: | Ríos-Tamayo, Rafael |
| Outros Autores: | Lupiañez, Carmen Belén; Campa, Daniele; Hielscher, Thomas; Weinhold, Niels; Martínez-López, Joaquin; Jerez, Andrés; Landi, Stefano; Reis, R. M.; Marques, Herlander |
| Assunto: | multiple myeloma diabetes genetic variants survival Ciências Médicas::Medicina Básica |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438690936029184 |
|---|---|
| author | Ríos-Tamayo, Rafael |
| author2 | Lupiañez, Carmen Belén Campa, Daniele Hielscher, Thomas Weinhold, Niels Martínez-López, Joaquin Jerez, Andrés Landi, Stefano Reis, R. M. Marques, Herlander |
| author2_role | author author author author author author author author author |
| author_facet | Ríos-Tamayo, Rafael Lupiañez, Carmen Belén Campa, Daniele Hielscher, Thomas Weinhold, Niels Martínez-López, Joaquin Jerez, Andrés Landi, Stefano Reis, R. M. Marques, Herlander |
| author_role | author |
| contributor_name_str_mv | [et. al.] RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ríos-Tamayo, Rafael\"},{\"Person.name\":\"Lupiañez, Carmen Belén\"},{\"Person.name\":\"Campa, Daniele\"},{\"Person.name\":\"Hielscher, Thomas\"},{\"Person.name\":\"Weinhold, Niels\"},{\"Person.name\":\"Martínez-López, Joaquin\"},{\"Person.name\":\"Jerez, Andrés\"},{\"Person.name\":\"Landi, Stefano\"},{\"Person.name\":\"Reis, R. M.\"},{\"Person.name\":\"Marques, Herlander\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | [et. al.] RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Ríos-Tamayo, Rafael Lupiañez, Carmen Belén Campa, Daniele Hielscher, Thomas Weinhold, Niels Martínez-López, Joaquin Jerez, Andrés Landi, Stefano Reis, R. M. Marques, Herlander |
| datacite.date.Accepted.fl_str_mv | 2016-09-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2017-04-19T10:30:10Z |
| datacite.date.embargoed.fl_str_mv | 2017-04-19T10:30:10Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | multiple myeloma diabetes genetic variants survival Ciências Médicas::Medicina Básica |
| datacite.titles.title.fl_str_mv | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| dc.contributor.none.fl_str_mv | [et. al.] RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Ríos-Tamayo, Rafael Lupiañez, Carmen Belén Campa, Daniele Hielscher, Thomas Weinhold, Niels Martínez-López, Joaquin Jerez, Andrés Landi, Stefano Reis, R. M. Marques, Herlander |
| dc.date.Accepted.fl_str_mv | 2016-09-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2017-04-19T10:30:10Z |
| dc.date.embargoed.fl_str_mv | 2017-04-19T10:30:10Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/45370 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Impact Journals |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | multiple myeloma diabetes genetic variants survival Ciências Médicas::Medicina Básica |
| dc.title.fl_str_mv | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec = 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8(rs13266634) SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1B(rs7501939) SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/e9c8ec32-a728-4913-bb86-ad1402335519/download |
| id | rum_be24ea2f539f5a5c85edf7f8283f028a |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/45370 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/45370 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Ríos-Tamayo, Rafael Lupiañez, Carmen Belén Campa, Daniele Hielscher, Thomas Weinhold, Niels Martínez-López, Joaquin Jerez, Andrés Landi, Stefano Reis, R. M. Marques, Herlander |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Impact Journals |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engImpact JournalsporDiabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec = 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8(rs13266634) SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1B(rs7501939) SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.application/pdfporA common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysisRíos-Tamayo, RafaelLupiañez, Carmen BelénCampa, DanieleHielscher, ThomasWeinhold, NielsMartínez-López, JoaquinJerez, AndrésLandi, StefanoReis, R. M.Marques, Herlander[et. al.]HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONRíos-Tamayo, R., Lupiañez, C. B., Campa, D., Hielscher, T., Weinhold, N., Martínez-López, J., et. al.(2016). A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: Results from the IMMEnSE consortium and meta-analysis. Oncotarget, 7(37), 59029PMID27437873ISSNIsPartOf1949-2553EISSNIsPartOf1949-2553DOIIsPartOf10.18632/oncotarget.106652017-04-19T10:30:10Z2016-092016-042017-03-01T11:16:13Z2016-09-01T00:00:00ZHandlehttps://hdl.handle.net/1822/45370http://purl.org/coar/access_right/c_abf2open accessmultiple myelomadiabetesgenetic variantssurvivalhttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Ciências Médicas::Medicina Básica5917893 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/e9c8ec32-a728-4913-bb86-ad1402335519/download |
| spellingShingle | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis Ríos-Tamayo, Rafael multiple myeloma diabetes genetic variants survival Ciências Médicas::Medicina Básica |
| status | SINGLETON |
| subject.fl_str_mv | multiple myeloma diabetes genetic variants survival |
| subject.other.fl_str_mv | Ciências Médicas::Medicina Básica |
| title | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| title_full | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| title_fullStr | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| title_full_unstemmed | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| title_short | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| title_sort | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
| topic | multiple myeloma diabetes genetic variants survival Ciências Médicas::Medicina Básica |
| topic_facet | multiple myeloma diabetes genetic variants survival Ciências Médicas::Medicina Básica |
| url | https://hdl.handle.net/1822/45370 |
| visible | 1 |