Publicação
Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium
| Resumo: | Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies. |
|---|---|
| Autores principais: | Reis, R. M. |
| Outros Autores: | Campa, Danielr; Martino, Alessandro; Sainz, Juan; Buda, Gabriele; Jamroziak, Krzysztof; Weinhold, Niels; García-Sanz, Ramón; Jurado, Manuel; Ríos, Rafael; Szemraj-Rogucka, Zofia; Marques, Herlander; Lesueur, Fabienne; Bugert, Peter; Moreno, Victor; Szemraj, Janusz; Orciuolo, Enrico; Gemignani, Federica; Petrini, Mario; Goldschmidt, Hartmut; Landi, Stefano; Canzian, Federico |
| Assunto: | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866876173921812480 |
|---|---|
| author | Reis, R. M. |
| author2 | Campa, Danielr Martino, Alessandro Sainz, Juan Buda, Gabriele Jamroziak, Krzysztof Weinhold, Niels García-Sanz, Ramón Jurado, Manuel Ríos, Rafael Szemraj-Rogucka, Zofia Marques, Herlander Lesueur, Fabienne Bugert, Peter Moreno, Victor Szemraj, Janusz Orciuolo, Enrico Gemignani, Federica Petrini, Mario Goldschmidt, Hartmut Landi, Stefano Canzian, Federico |
| author2_role | author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Reis, R. M. Campa, Danielr Martino, Alessandro Sainz, Juan Buda, Gabriele Jamroziak, Krzysztof Weinhold, Niels García-Sanz, Ramón Jurado, Manuel Ríos, Rafael Szemraj-Rogucka, Zofia Marques, Herlander Lesueur, Fabienne Bugert, Peter Moreno, Victor Szemraj, Janusz Orciuolo, Enrico Gemignani, Federica Petrini, Mario Goldschmidt, Hartmut Landi, Stefano Canzian, Federico |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Reis, R. M.\"},{\"Person.name\":\"Campa, Danielr\"},{\"Person.name\":\"Martino, Alessandro\"},{\"Person.name\":\"Sainz, Juan\"},{\"Person.name\":\"Buda, Gabriele\"},{\"Person.name\":\"Jamroziak, Krzysztof\"},{\"Person.name\":\"Weinhold, Niels\"},{\"Person.name\":\"García-Sanz, Ramón\"},{\"Person.name\":\"Jurado, Manuel\"},{\"Person.name\":\"Ríos, Rafael\"},{\"Person.name\":\"Szemraj-Rogucka, Zofia\"},{\"Person.name\":\"Marques, Herlander\"},{\"Person.name\":\"Lesueur, Fabienne\"},{\"Person.name\":\"Bugert, Peter\"},{\"Person.name\":\"Moreno, Victor\"},{\"Person.name\":\"Szemraj, Janusz\"},{\"Person.name\":\"Orciuolo, Enrico\"},{\"Person.name\":\"Gemignani, Federica\"},{\"Person.name\":\"Petrini, Mario\"},{\"Person.name\":\"Goldschmidt, Hartmut\"},{\"Person.name\":\"Landi, Stefano\"},{\"Person.name\":\"Canzian, Federico\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Reis, R. M. Campa, Danielr Martino, Alessandro Sainz, Juan Buda, Gabriele Jamroziak, Krzysztof Weinhold, Niels García-Sanz, Ramón Jurado, Manuel Ríos, Rafael Szemraj-Rogucka, Zofia Marques, Herlander Lesueur, Fabienne Bugert, Peter Moreno, Victor Szemraj, Janusz Orciuolo, Enrico Gemignani, Federica Petrini, Mario Goldschmidt, Hartmut Landi, Stefano Canzian, Federico |
| datacite.date.Accepted.fl_str_mv | 2012-05-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-02-05T12:39:52Z |
| datacite.date.embargoed.fl_str_mv | 2015-02-05T12:39:52Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| datacite.titles.title.fl_str_mv | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Reis, R. M. Campa, Danielr Martino, Alessandro Sainz, Juan Buda, Gabriele Jamroziak, Krzysztof Weinhold, Niels García-Sanz, Ramón Jurado, Manuel Ríos, Rafael Szemraj-Rogucka, Zofia Marques, Herlander Lesueur, Fabienne Bugert, Peter Moreno, Victor Szemraj, Janusz Orciuolo, Enrico Gemignani, Federica Petrini, Mario Goldschmidt, Hartmut Landi, Stefano Canzian, Federico |
| dc.date.Accepted.fl_str_mv | 2012-05-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-02-05T12:39:52Z |
| dc.date.embargoed.fl_str_mv | 2015-02-05T12:39:52Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/33602 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Blackwell Publishing |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| dc.title.fl_str_mv | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/9bc52a26-9ca4-4bec-b3f0-a7d13c29779d/download |
| id | rum_c6dfd5f4f6012c059f7a4db04f2c35e8 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/33602 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/33602 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Reis, R. M. Campa, Danielr Martino, Alessandro Sainz, Juan Buda, Gabriele Jamroziak, Krzysztof Weinhold, Niels García-Sanz, Ramón Jurado, Manuel Ríos, Rafael Szemraj-Rogucka, Zofia Marques, Herlander Lesueur, Fabienne Bugert, Peter Moreno, Victor Szemraj, Janusz Orciuolo, Enrico Gemignani, Federica Petrini, Mario Goldschmidt, Hartmut Landi, Stefano Canzian, Federico |
| publishDate | 2012 |
| publisher.none.fl_str_mv | Blackwell Publishing |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engBlackwell PublishingporGenome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.application/pdfporComprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortiumReis, R. M.Campa, DanielrMartino, AlessandroSainz, JuanBuda, GabrieleJamroziak, KrzysztofWeinhold, NielsGarcía-Sanz, RamónJurado, ManuelRíos, RafaelSzemraj-Rogucka, ZofiaMarques, HerlanderLesueur, FabienneBugert, PeterMoreno, VictorSzemraj, JanuszOrciuolo, EnricoGemignani, FedericaPetrini, MarioGoldschmidt, HartmutLandi, StefanoCanzian, FedericoHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf0007-1048DOIIsPartOf10.1111/j.1365-2141.2012.09047.x2015-02-05T12:39:52Z2012-052015-01-30T16:29:34Z2012-05-01T00:00:00ZHandlehttps://hdl.handle.net/1822/33602http://purl.org/coar/access_right/c_16ecrestricted accessGeneticsCancer geneticsCancerEpidemiologyHaematological malignanciesMyeloma90639 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/9bc52a26-9ca4-4bec-b3f0-a7d13c29779d/download |
| spellingShingle | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium Reis, R. M. Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| status | SINGLETON |
| subject.fl_str_mv | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| title | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| title_full | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| title_fullStr | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| title_full_unstemmed | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| title_short | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| title_sort | Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium |
| topic | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| topic_facet | Genetics Cancer genetics Cancer Epidemiology Haematological malignancies Myeloma |
| url | https://hdl.handle.net/1822/33602 |
| visible | 1 |