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Light-induced cleavage of model phenylalanine conjugates based on coumarins and quinolones

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Resumo:In order to evaluate the application of quinolone as a new photocleavable protecting group, in comparison with coumarin, a series of model phenylalanine conjugates were prepared by reaction with chloromethylated O and N heterocycles. The photophysical properties of the resulting ester conjugates were evaluated as well as the photosensitivity under irradiation at 250, 300, 350, and 419 nm. The results obtained showed that the quinolone conjugates were readily photolysed, with complete release of the amino acid in short irradiation times and could be considered a new addition to the family of photocleavable protecting groups for the carboxylic acid function of amino acids.
Autores principais:Fonseca, Andrea S. C.
Outros Autores:Gonçalves, M. Sameiro T.; Costa, Susana P. G.
Assunto:Coumarin Quinolone Bioconjugates Amino acids Photocleavable protecting groups
Ano:2010
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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