Publicação
PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour
| Resumo: | The use of animals is essential in biomedical research. The laboratory environment where the animals are housed has a major impact on them throughout their lives and influences the outcome of animal experiments. Therefore, there has been an increased effort in the refinement of laboratory housing conditions which is explicitly reflected in international regulations and recommendations. Since housing conditions affect behaviour and brain function as well as well-being, the validation of an animal model or paradigm to study the brain and central nervous system disorders is not complete without an evaluation of its implication on animal welfare. Here we discuss several aspects of animal welfare, comparing groups of six rats living in the PhenoWorld (PhW), a recently developed and validated paradigm for studying rodent behaviour, with standard-housed animals (in cages of six rats or pair-housed). In this study we present new data on home-cage behaviour showing that PhW animals have a clearer circadian pattern of sleep and social interaction. We conclude that, by promoting good basic health and functioning, together with the performance of natural behaviours, and maintaining animals' control over some of their environment but still keeping some physical and social challenges, the PhW stimulates positive affective states and higher motivation in rats, which might contribute to an increased welfare for animals living in the PhW. |
|---|---|
| Autores principais: | Castelhano-Carlos, Magda João |
| Outros Autores: | Baumans, Vera; Sousa, Nuno |
| Assunto: | Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438885585289216 |
|---|---|
| author | Castelhano-Carlos, Magda João |
| author2 | Baumans, Vera Sousa, Nuno |
| author2_role | author author |
| author_facet | Castelhano-Carlos, Magda João Baumans, Vera Sousa, Nuno |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Castelhano-Carlos, Magda João\"},{\"Person.name\":\"Baumans, Vera\"},{\"Person.name\":\"Sousa, Nuno\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Castelhano-Carlos, Magda João Baumans, Vera Sousa, Nuno |
| datacite.date.Accepted.fl_str_mv | 2017-02-01T00:00:00Z |
| datacite.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| datacite.titles.title.fl_str_mv | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Castelhano-Carlos, Magda João Baumans, Vera Sousa, Nuno |
| dc.date.Accepted.fl_str_mv | 2017-02-01T00:00:00Z |
| dc.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/62009 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | SAGE Publications |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| dc.title.fl_str_mv | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The use of animals is essential in biomedical research. The laboratory environment where the animals are housed has a major impact on them throughout their lives and influences the outcome of animal experiments. Therefore, there has been an increased effort in the refinement of laboratory housing conditions which is explicitly reflected in international regulations and recommendations. Since housing conditions affect behaviour and brain function as well as well-being, the validation of an animal model or paradigm to study the brain and central nervous system disorders is not complete without an evaluation of its implication on animal welfare. Here we discuss several aspects of animal welfare, comparing groups of six rats living in the PhenoWorld (PhW), a recently developed and validated paradigm for studying rodent behaviour, with standard-housed animals (in cages of six rats or pair-housed). In this study we present new data on home-cage behaviour showing that PhW animals have a clearer circadian pattern of sleep and social interaction. We conclude that, by promoting good basic health and functioning, together with the performance of natural behaviours, and maintaining animals' control over some of their environment but still keeping some physical and social challenges, the PhW stimulates positive affective states and higher motivation in rats, which might contribute to an increased welfare for animals living in the PhW. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/0f0dfb1d-d85f-4950-89d0-53bc51d3acb8/download |
| id | rum_cdf619cf5dae49ff894e877b18ca2b08 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/62009 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/62009 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Castelhano-Carlos, Magda João Baumans, Vera Sousa, Nuno |
| publishDate | 2017 |
| publisher.none.fl_str_mv | SAGE Publications |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engSAGE PublicationsporThe use of animals is essential in biomedical research. The laboratory environment where the animals are housed has a major impact on them throughout their lives and influences the outcome of animal experiments. Therefore, there has been an increased effort in the refinement of laboratory housing conditions which is explicitly reflected in international regulations and recommendations. Since housing conditions affect behaviour and brain function as well as well-being, the validation of an animal model or paradigm to study the brain and central nervous system disorders is not complete without an evaluation of its implication on animal welfare. Here we discuss several aspects of animal welfare, comparing groups of six rats living in the PhenoWorld (PhW), a recently developed and validated paradigm for studying rodent behaviour, with standard-housed animals (in cages of six rats or pair-housed). In this study we present new data on home-cage behaviour showing that PhW animals have a clearer circadian pattern of sleep and social interaction. We conclude that, by promoting good basic health and functioning, together with the performance of natural behaviours, and maintaining animals' control over some of their environment but still keeping some physical and social challenges, the PhW stimulates positive affective states and higher motivation in rats, which might contribute to an increased welfare for animals living in the PhW.application/pdfporPhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviourCastelhano-Carlos, Magda JoãoBaumans, VeraSousa, NunoHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID26985009ISSNIsPartOf0023-6772EISSNIsPartOf1758-1117DOIIsPartOf10.1177/00236772166386422017-022017-02-01T00:00:00Z10000-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/62009http://purl.org/coar/access_right/c_16ecrestricted accessAnimal WelfareAnimalsHousing, AnimalMaleRatsRats, WistarSpecific Pathogen-Free OrganismsSleepSocial BehaviorEnvironmental enrichmentLaboratory animal welfareRefinementhousingsocial behaviour133332 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_f1cfapplication/pdffulltexthttps://repositorium.uminho.pt/bitstreams/0f0dfb1d-d85f-4950-89d0-53bc51d3acb8/download |
| spellingShingle | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour Castelhano-Carlos, Magda João Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| status | SINGLETON |
| subject.fl_str_mv | Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| title | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| title_full | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| title_fullStr | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| title_full_unstemmed | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| title_short | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| title_sort | PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour |
| topic | Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| topic_facet | Animal Welfare Animals Housing, Animal Male Rats Rats, Wistar Specific Pathogen-Free Organisms Sleep Social Behavior Environmental enrichment Laboratory animal welfare Refinement housing social behaviour |
| url | https://hdl.handle.net/1822/62009 |
| visible | 1 |