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Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: the quality of liquid-based preparation of cytological slides

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Resumo:The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. bjectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduodenoscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.
Autores principais:Mariano, Vânia S.
Outros Autores:Pastrez, Paula R. A.; Mafra Costa, Allini; Guimarães, Denise P.; Cunha, Thiago R.; Neto, Said A. Z.; Scapulatempo-Neto, Christóvam; Syrjänen, Kari J.; Longatto, Adhemar
Assunto:Biopsy Cross-Sectional Studies Cytodiagnosis Cytological Techniques Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Esophagus Female Humans Male Middle Aged Preservatives, Pharmaceutical Prospective Studies Sensitivity and Specificity Tissue Preservation Esophageal squamous cell cancer Brush cytology Liquid-based cytology SurePath Ciências Médicas::Medicina Básica
Ano:2019
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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