Publicação
Transthyretin is involved in depression-like behaviour and exploratory activity
| Resumo: | Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system. |
|---|---|
| Autores principais: | Sousa, João Carlos |
| Outros Autores: | Grandela, Catarina; Fernández-Ruiz, Javier; Miguel, Rosário de; Sousa, Liliana de; Magalhães, Ana Isabel; Saraiva, Maria João; Sousa, Nuno; Palha, Joana Almeida |
| Assunto: | Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| Ano: | 2004 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866876871064420352 |
|---|---|
| author | Sousa, João Carlos |
| author2 | Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
| author2_role | author author author author author author author author |
| author_facet | Sousa, João Carlos Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sousa, João Carlos\"},{\"Person.name\":\"Grandela, Catarina\"},{\"Person.name\":\"Fernández-Ruiz, Javier\"},{\"Person.name\":\"Miguel, Rosário de\"},{\"Person.name\":\"Sousa, Liliana de\"},{\"Person.name\":\"Magalhães, Ana Isabel\"},{\"Person.name\":\"Saraiva, Maria João\"},{\"Person.name\":\"Sousa, Nuno\"},{\"Person.name\":\"Palha, Joana Almeida\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Sousa, João Carlos Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
| datacite.date.Accepted.fl_str_mv | 2004-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2005-05-18T14:10:12Z |
| datacite.date.embargoed.fl_str_mv | 2005-05-18T14:10:12Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| datacite.titles.title.fl_str_mv | Transthyretin is involved in depression-like behaviour and exploratory activity |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Sousa, João Carlos Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
| dc.date.Accepted.fl_str_mv | 2004-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2005-05-18T14:10:12Z |
| dc.date.embargoed.fl_str_mv | 2005-05-18T14:10:12Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/1657 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| dc.title.fl_str_mv | Transthyretin is involved in depression-like behaviour and exploratory activity |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/a618d25f-47cd-4390-86f9-72f474283d74/download |
| id | rum_d6d2b907f5ef3cdf1f039b3a2d2f7b01 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/1657 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/1657 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Sousa, João Carlos Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
| publishDate | 2004 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWileyengTransthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system.application/pdfengTransthyretin is involved in depression-like behaviour and exploratory activitySousa, João CarlosGrandela, CatarinaFernández-Ruiz, JavierMiguel, Rosário deSousa, Liliana deMagalhães, Ana IsabelSaraiva, Maria JoãoSousa, NunoPalha, Joana AlmeidaHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf0022-3042ISSNIsPartOf1471-4159DOIIsPartOf10.1046/j.1471-4159.2003.02309.x2005-05-18T14:10:12Z20042004-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/1657http://purl.org/coar/access_right/c_abf2open accessBehaviourRetinoidsNorepinephrineThyroid hormoneThyroxineTransthyretin299757 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/a618d25f-47cd-4390-86f9-72f474283d74/download |
| spellingShingle | Transthyretin is involved in depression-like behaviour and exploratory activity Sousa, João Carlos Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| status | SINGLETON |
| subject.fl_str_mv | Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| title | Transthyretin is involved in depression-like behaviour and exploratory activity |
| title_full | Transthyretin is involved in depression-like behaviour and exploratory activity |
| title_fullStr | Transthyretin is involved in depression-like behaviour and exploratory activity |
| title_full_unstemmed | Transthyretin is involved in depression-like behaviour and exploratory activity |
| title_short | Transthyretin is involved in depression-like behaviour and exploratory activity |
| title_sort | Transthyretin is involved in depression-like behaviour and exploratory activity |
| topic | Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| topic_facet | Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin |
| url | https://hdl.handle.net/1822/1657 |
| visible | 1 |