Publicação
Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis
| Resumo: | Aim: Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to distant organ metastasis. The systemic chemotherapy has a minimal effect in peritoneal metastasis so new types of treatment have emerged. The authors revised the main studies done in pressurized intraperitoneal aerosol chemotherapy (PIPAC) and presented the main conclusions. Methods: A PubMed search was conducted focusing on PIPAC in gastric cancer. The MeSH database was searched with the terms: “Gastric cancer [MeSH] and intraperitoneal aerosol chemotherapy”. Results: Seven studies were analyzed. All the studies performed the technique with aerosol of doxorubicin and cisplatin. All cases were well tolerated, with minor adverse effects. Patients presented resolution of their abdominal symptoms and regression of macroscopic carcinomatosis. Cytoreductive surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to PIPAC. The peritonitis caused by the chemotherapy was well tolerated. Conclusion: PIPAC can induce remission in end-stage and resistant disease with acceptable side effects, good safety levels for patients and health professionals, and quality of life improvement. |
|---|---|
| Autores principais: | Macedo, Filipa |
| Outros Autores: | Ladeira, Kátia; Longatto, Adhemar; Martins, Sandra |
| Assunto: | Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis Ciências Médicas::Medicina Básica |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867439516894101504 |
|---|---|
| author | Macedo, Filipa |
| author2 | Ladeira, Kátia Longatto, Adhemar Martins, Sandra |
| author2_role | author author author |
| author_facet | Macedo, Filipa Ladeira, Kátia Longatto, Adhemar Martins, Sandra |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Macedo, Filipa\"},{\"Person.name\":\"Ladeira, Kátia\"},{\"Person.name\":\"Longatto, Adhemar\"},{\"Person.name\":\"Martins, Sandra\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Macedo, Filipa Ladeira, Kátia Longatto, Adhemar Martins, Sandra |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-01-14T17:27:35Z |
| datacite.date.embargoed.fl_str_mv | 2019-01-14T17:27:35Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis Ciências Médicas::Medicina Básica |
| datacite.titles.title.fl_str_mv | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Macedo, Filipa Ladeira, Kátia Longatto, Adhemar Martins, Sandra |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-01-14T17:27:35Z |
| dc.date.embargoed.fl_str_mv | 2019-01-14T17:27:35Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/58183 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | OAE Publishing Inc. (OAE) |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis Ciências Médicas::Medicina Básica |
| dc.title.fl_str_mv | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Aim: Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to distant organ metastasis. The systemic chemotherapy has a minimal effect in peritoneal metastasis so new types of treatment have emerged. The authors revised the main studies done in pressurized intraperitoneal aerosol chemotherapy (PIPAC) and presented the main conclusions. Methods: A PubMed search was conducted focusing on PIPAC in gastric cancer. The MeSH database was searched with the terms: “Gastric cancer [MeSH] and intraperitoneal aerosol chemotherapy”. Results: Seven studies were analyzed. All the studies performed the technique with aerosol of doxorubicin and cisplatin. All cases were well tolerated, with minor adverse effects. Patients presented resolution of their abdominal symptoms and regression of macroscopic carcinomatosis. Cytoreductive surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to PIPAC. The peritonitis caused by the chemotherapy was well tolerated. Conclusion: PIPAC can induce remission in end-stage and resistant disease with acceptable side effects, good safety levels for patients and health professionals, and quality of life improvement. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/5cb0e50e-8070-4c40-b83f-cd93e87d2989/download |
| id | rum_db389e8fccfee22dbaec251e2b1d754d |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/58183 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/58183 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Macedo, Filipa Ladeira, Kátia Longatto, Adhemar Martins, Sandra |
| publishDate | 2018 |
| publisher.none.fl_str_mv | OAE Publishing Inc. (OAE) |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engOAE Publishing Inc. (OAE)porAim: Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to distant organ metastasis. The systemic chemotherapy has a minimal effect in peritoneal metastasis so new types of treatment have emerged. The authors revised the main studies done in pressurized intraperitoneal aerosol chemotherapy (PIPAC) and presented the main conclusions. Methods: A PubMed search was conducted focusing on PIPAC in gastric cancer. The MeSH database was searched with the terms: “Gastric cancer [MeSH] and intraperitoneal aerosol chemotherapy”. Results: Seven studies were analyzed. All the studies performed the technique with aerosol of doxorubicin and cisplatin. All cases were well tolerated, with minor adverse effects. Patients presented resolution of their abdominal symptoms and regression of macroscopic carcinomatosis. Cytoreductive surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to PIPAC. The peritonitis caused by the chemotherapy was well tolerated. Conclusion: PIPAC can induce remission in end-stage and resistant disease with acceptable side effects, good safety levels for patients and health professionals, and quality of life improvement.application/pdfporGastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosisMacedo, FilipaLadeira, KátiaLongatto, AdhemarMartins, SandraHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf2394-4722EISSNIsPartOf2454-2857DOIIsPartOf10.20517/2394-4722.2017.722019-01-14T17:27:35Z20182018-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/58183http://purl.org/coar/access_right/c_abf2open accessPressurized intraperitoneal aerosol chemotherapyGastric cancerPeritoneal carcinomatosishttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Ciências Médicas::Medicina Básica517843 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/5cb0e50e-8070-4c40-b83f-cd93e87d2989/download |
| spellingShingle | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis Macedo, Filipa Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis Ciências Médicas::Medicina Básica |
| status | SINGLETON |
| subject.fl_str_mv | Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis |
| subject.other.fl_str_mv | Ciências Médicas::Medicina Básica |
| title | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| title_full | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| title_fullStr | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| title_full_unstemmed | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| title_short | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| title_sort | Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis |
| topic | Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis Ciências Médicas::Medicina Básica |
| topic_facet | Pressurized intraperitoneal aerosol chemotherapy Gastric cancer Peritoneal carcinomatosis Ciências Médicas::Medicina Básica |
| url | https://hdl.handle.net/1822/58183 |
| visible | 1 |