Publicação
Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells
| Resumo: | Aim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115â 140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35â 42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells. |
|---|---|
| Autores principais: | Oliveira, Catarina |
| Outros Autores: | Neves, N. M.; Reis, R. L.; Martins, A.; Silva, T. H. |
| Assunto: | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866270366711676928 |
|---|---|
| author | Oliveira, Catarina |
| author2 | Neves, N. M. Reis, R. L. Martins, A. Silva, T. H. |
| author2_role | author author author author |
| author_facet | Oliveira, Catarina Neves, N. M. Reis, R. L. Martins, A. Silva, T. H. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Oliveira, Catarina\"},{\"Person.name\":\"Neves, N. M.\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Martins, A.\"},{\"Person.name\":\"Silva, T. H.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Oliveira, Catarina Neves, N. M. Reis, R. L. Martins, A. Silva, T. H. |
| datacite.date.Accepted.fl_str_mv | 2018-09-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-01-30T11:05:23Z |
| datacite.date.embargoed.fl_str_mv | 2019-01-30T11:05:23Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| datacite.titles.title.fl_str_mv | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Oliveira, Catarina Neves, N. M. Reis, R. L. Martins, A. Silva, T. H. |
| dc.date.Accepted.fl_str_mv | 2018-09-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-01-30T11:05:23Z |
| dc.date.embargoed.fl_str_mv | 2019-01-30T11:05:23Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/58734 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Future Medicine Ltd |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| dc.title.fl_str_mv | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Aim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115â 140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35â 42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/c4f8150e-28c4-4800-bbef-b7cb33abb66b/download |
| id | rum_dcbf4df4d0660443f89fe6fb2d24c8bb |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/58734 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/58734 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Oliveira, Catarina Neves, N. M. Reis, R. L. Martins, A. Silva, T. H. |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Future Medicine Ltd |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engFuture Medicine LtdporAim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115â 140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35â 42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells.application/pdfporGemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cellsOliveira, CatarinaNeves, N. M.Reis, R. L.Martins, A.Silva, T. H.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1743-5889DOIIsPartOf10.2217/nnm-2018-00042019-01-30T11:05:23Z2018-092018-112019-01-30T09:50:11Z2018-09-01T00:00:00ZHandlehttps://hdl.handle.net/1822/58734http://purl.org/coar/access_right/c_abf2open accessbreast cancer cellsChitosanDrug Delivery Systemendothelial cellsFucoidangemcitabineNanoparticlesPolyelectrolyte complexation2933782 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/c4f8150e-28c4-4800-bbef-b7cb33abb66b/download |
| spellingShingle | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells Oliveira, Catarina breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| status | SINGLETON |
| subject.fl_str_mv | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| title | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| title_full | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| title_fullStr | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| title_full_unstemmed | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| title_short | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| title_sort | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
| topic | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| topic_facet | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
| url | https://hdl.handle.net/1822/58734 |
| visible | 1 |