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A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation

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Resumo:The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via the integration of Transcriptional Regulatory Networks and/or gene expression data. Although the surveyed methods are aimed at improving phenotype simulations obtained from these models, the perspective of reconstructing integrated genome-scale models of metabolism and gene expression for diverse prokaryotes is still an open challenge.
Autores principais:Cruz, Fernando
Outros Autores:Faria, José Pedro; Rocha, Miguel; Rocha, Isabel; Dias, Oscar
Assunto:Flux balance analysis Gene expression and regulation Genome-scale metabolic models Genome-scale regulatory networks Metabolism Transcriptional regulatory networks
Ano:2020
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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