Detalhes bibliográficos
| Resumo: | Bone marrow mesenchymal stem cells have been extensively used for tissue engineering and regenerative medicine applications due to their ease of isolation and expansion and their ability to differentiate towards various lineages of mesodermal origin. Despite these properties, their clinical potential is often hampered by the simplicity of the in vitro environment and its inability to resemble the complex in vivo niche. Herein, different microenvironmental cues (e.g. surface topography, substrate stiffness, mechanical stimulation, oxygen tension and co-culture systems) that have been utilised to enhance the therapeutic efficacy of bone marrow mesenchymal stem cells are discussed. |
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| Autores principais: | Tsiapalis, D. |
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| Outros Autores: | Ribeiro, S.; De Pieri, A.; Sallent, I.; Guillaumin, S.; Gaspar, D.; Korntner, S.; Bayon, Y.; Gomes, Manuela E.; Reis, R. L.; Zeugolis, D. I. |
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| Assunto: | Microenvironmental cues Surface topography Tissue engineering Bone marrow mesenchymal stem cells Coculture systems Low oxygen tension Mechanical loading Substrate stiffness |
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| Ano: | 2019 |
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| País: | Portugal |
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| Tipo de documento: | capítulo de livro |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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