Publicação
Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion
| Resumo: | Nanoemulsions can be used to improve the bioaccessibility of lipophilic bioactive compounds, such as curcumin, being their behaviour highly influenced by their interfacial properties. The effect of chitosan and alginate layers deposition on curcumin nanoemulsions behaviour during in vitro digestion was evaluated using a dynamic gastrointestinal system. Results showed that polyelectrolyte layers deposition improved curcumin antioxidant capacity during in vitro digestion. In addition, multilayer nanoemulsions showed a better control of the rate and extent of lipid digestibility by decreasing free fatty acids release, compared to uncoated nanoemulsions. However, a lower curcumin bioaccessibility was observed for multilayer nanoemulsions. Although cytotoxicity assays revealed that both nanosystems are toxic due to the use of sodium dodecyl sulphate (SDS), nanosystems were 3.3-fold less toxic than SDS itself. This study showed that multilayer nanoemulsions could be used to increase satiety by retarding lipid digestion, which can be important for functional foods development for combating obesity. |
|---|---|
| Autores principais: | Silva, Hélder D. |
| Outros Autores: | Poejo, Joana; Pinheiro, Ana Cristina; Donsì, Francesco; Serra, Ana Teresa; Duarte, Catarina M. M.; Ferrari, Giovanna; Cerqueira, Miguel Ângelo Parente Ribeiro; Vicente, A. A. |
| Assunto: | Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866270093160218624 |
|---|---|
| author | Silva, Hélder D. |
| author2 | Poejo, Joana Pinheiro, Ana Cristina Donsì, Francesco Serra, Ana Teresa Duarte, Catarina M. M. Ferrari, Giovanna Cerqueira, Miguel Ângelo Parente Ribeiro Vicente, A. A. |
| author2_role | author author author author author author author author |
| author_facet | Silva, Hélder D. Poejo, Joana Pinheiro, Ana Cristina Donsì, Francesco Serra, Ana Teresa Duarte, Catarina M. M. Ferrari, Giovanna Cerqueira, Miguel Ângelo Parente Ribeiro Vicente, A. A. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Silva, Hélder D.\"},{\"Person.name\":\"Poejo, Joana\"},{\"Person.name\":\"Pinheiro, Ana Cristina\"},{\"Person.name\":\"Donsì, Francesco\"},{\"Person.name\":\"Serra, Ana Teresa\"},{\"Person.name\":\"Duarte, Catarina M. M.\"},{\"Person.name\":\"Ferrari, Giovanna\"},{\"Person.name\":\"Cerqueira, Miguel Ângelo Parente Ribeiro\"},{\"Person.name\":\"Vicente, A. A.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Silva, Hélder D. Poejo, Joana Pinheiro, Ana Cristina Donsì, Francesco Serra, Ana Teresa Duarte, Catarina M. M. Ferrari, Giovanna Cerqueira, Miguel Ângelo Parente Ribeiro Vicente, A. A. |
| datacite.date.Accepted.fl_str_mv | 2018-09-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-09-05T14:48:20Z |
| datacite.date.embargoed.fl_str_mv | 2018-09-05T14:48:20Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| datacite.titles.title.fl_str_mv | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Silva, Hélder D. Poejo, Joana Pinheiro, Ana Cristina Donsì, Francesco Serra, Ana Teresa Duarte, Catarina M. M. Ferrari, Giovanna Cerqueira, Miguel Ângelo Parente Ribeiro Vicente, A. A. |
| dc.date.Accepted.fl_str_mv | 2018-09-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-09-05T14:48:20Z |
| dc.date.embargoed.fl_str_mv | 2018-09-05T14:48:20Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/55757 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| dc.title.fl_str_mv | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Nanoemulsions can be used to improve the bioaccessibility of lipophilic bioactive compounds, such as curcumin, being their behaviour highly influenced by their interfacial properties. The effect of chitosan and alginate layers deposition on curcumin nanoemulsions behaviour during in vitro digestion was evaluated using a dynamic gastrointestinal system. Results showed that polyelectrolyte layers deposition improved curcumin antioxidant capacity during in vitro digestion. In addition, multilayer nanoemulsions showed a better control of the rate and extent of lipid digestibility by decreasing free fatty acids release, compared to uncoated nanoemulsions. However, a lower curcumin bioaccessibility was observed for multilayer nanoemulsions. Although cytotoxicity assays revealed that both nanosystems are toxic due to the use of sodium dodecyl sulphate (SDS), nanosystems were 3.3-fold less toxic than SDS itself. This study showed that multilayer nanoemulsions could be used to increase satiety by retarding lipid digestion, which can be important for functional foods development for combating obesity. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/fa8f1fae-2ff3-4be7-a2b0-2deae92306c9/download |
| id | rum_e9e2a8ff07a1f97fb83fd215cdf73afc |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/55757 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/55757 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Silva, Hélder D. Poejo, Joana Pinheiro, Ana Cristina Donsì, Francesco Serra, Ana Teresa Duarte, Catarina M. M. Ferrari, Giovanna Cerqueira, Miguel Ângelo Parente Ribeiro Vicente, A. A. |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engElsevierporNanoemulsions can be used to improve the bioaccessibility of lipophilic bioactive compounds, such as curcumin, being their behaviour highly influenced by their interfacial properties. The effect of chitosan and alginate layers deposition on curcumin nanoemulsions behaviour during in vitro digestion was evaluated using a dynamic gastrointestinal system. Results showed that polyelectrolyte layers deposition improved curcumin antioxidant capacity during in vitro digestion. In addition, multilayer nanoemulsions showed a better control of the rate and extent of lipid digestibility by decreasing free fatty acids release, compared to uncoated nanoemulsions. However, a lower curcumin bioaccessibility was observed for multilayer nanoemulsions. Although cytotoxicity assays revealed that both nanosystems are toxic due to the use of sodium dodecyl sulphate (SDS), nanosystems were 3.3-fold less toxic than SDS itself. This study showed that multilayer nanoemulsions could be used to increase satiety by retarding lipid digestion, which can be important for functional foods development for combating obesity.application/pdfporEvaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestionSilva, Hélder D.Poejo, JoanaPinheiro, Ana CristinaDonsì, FrancescoSerra, Ana TeresaDuarte, Catarina M. M.Ferrari, GiovannaCerqueira, Miguel Ângelo Parente RibeiroVicente, A. A.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1756-4646DOIIsPartOf10.1016/j.jff.2018.08.0022018-09-05T14:48:20Z2018-092018-09-04T16:56:17Z2018-09-01T00:00:00ZHandlehttps://hdl.handle.net/1822/55757http://purl.org/coar/access_right/c_abf2open accessLayer-by-layerPolyelectrolytesMultilayer nanoemulsionsLipid digestionBioaccessibility and cytotoxicity1070600 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/fa8f1fae-2ff3-4be7-a2b0-2deae92306c9/download |
| spellingShingle | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion Silva, Hélder D. Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| status | SINGLETON |
| subject.fl_str_mv | Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| title | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| title_full | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| title_fullStr | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| title_full_unstemmed | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| title_short | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| title_sort | Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion |
| topic | Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| topic_facet | Layer-by-layer Polyelectrolytes Multilayer nanoemulsions Lipid digestion Bioaccessibility and cytotoxicity |
| url | https://hdl.handle.net/1822/55757 |
| visible | 1 |