Publicação
Microbes and cancer: friends or faux?
| Resumo: | Cancer is one of the most aggressive and deadly diseases in the world, representing the second leading cause of death. It is a multifactorial disease, in which genetic alterations play a key role, but several environmental factors also contribute to its development and progression. Infections induced by certain viruses, bacteria, fungi and parasites constitute risk factors for cancer, being chronic infection associated to the development of certain types of cancer. On the other hand, susceptibility to infectious diseases is higher in cancer patients. The state of the host immune system plays a crucial role in the susceptibility to both infection and cancer. Importantly, immunosuppressive cancer treatments increase the risk of infection, by decreasing the host defenses. Furthermore, alterations in the host microbiota is also a key factor in the susceptibility to develop cancer. More recently, the identification of a tumor microbiota, in which bacteria establish a symbiotic relationship with cancer cells, opened a new area of research. There is evidence demonstrating that the interaction between bacteria and cancer cells can modulate the anticancer drug response and toxicity. The present review focuses on the interaction between microbes and cancer, specifically aiming to: (1) review the main infectious agents associated with development of cancer and the role of microbiota in cancer susceptibility; (2) highlight the higher vulnerability of cancer patients to acquire infectious diseases; (3) document the relationship between cancer cells and tissue microbiota; (4) describe the role of intratumoral bacteria in the response and toxicity to cancer therapy. |
|---|---|
| Autores principais: | Azevedo, Maria Manuel |
| Outros Autores: | Pina-Vaz, Cidália; Baltazar, Fátima |
| Assunto: | cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866875658651566080 |
|---|---|
| author | Azevedo, Maria Manuel |
| author2 | Pina-Vaz, Cidália Baltazar, Fátima |
| author2_role | author author |
| author_facet | Azevedo, Maria Manuel Pina-Vaz, Cidália Baltazar, Fátima |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Azevedo, Maria Manuel\"},{\"Person.name\":\"Pina-Vaz, Cidália\"},{\"Person.name\":\"Baltazar, Fátima\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Azevedo, Maria Manuel Pina-Vaz, Cidália Baltazar, Fátima |
| datacite.date.Accepted.fl_str_mv | 2020-04-28T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-05-18T09:33:05Z |
| datacite.date.embargoed.fl_str_mv | 2020-05-18T09:33:05Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| datacite.titles.title.fl_str_mv | Microbes and cancer: friends or faux? |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Azevedo, Maria Manuel Pina-Vaz, Cidália Baltazar, Fátima |
| dc.date.Accepted.fl_str_mv | 2020-04-28T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-05-18T09:33:05Z |
| dc.date.embargoed.fl_str_mv | 2020-05-18T09:33:05Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/65395 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| dc.title.fl_str_mv | Microbes and cancer: friends or faux? |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Cancer is one of the most aggressive and deadly diseases in the world, representing the second leading cause of death. It is a multifactorial disease, in which genetic alterations play a key role, but several environmental factors also contribute to its development and progression. Infections induced by certain viruses, bacteria, fungi and parasites constitute risk factors for cancer, being chronic infection associated to the development of certain types of cancer. On the other hand, susceptibility to infectious diseases is higher in cancer patients. The state of the host immune system plays a crucial role in the susceptibility to both infection and cancer. Importantly, immunosuppressive cancer treatments increase the risk of infection, by decreasing the host defenses. Furthermore, alterations in the host microbiota is also a key factor in the susceptibility to develop cancer. More recently, the identification of a tumor microbiota, in which bacteria establish a symbiotic relationship with cancer cells, opened a new area of research. There is evidence demonstrating that the interaction between bacteria and cancer cells can modulate the anticancer drug response and toxicity. The present review focuses on the interaction between microbes and cancer, specifically aiming to: (1) review the main infectious agents associated with development of cancer and the role of microbiota in cancer susceptibility; (2) highlight the higher vulnerability of cancer patients to acquire infectious diseases; (3) document the relationship between cancer cells and tissue microbiota; (4) describe the role of intratumoral bacteria in the response and toxicity to cancer therapy. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/1b7a0284-9205-4da4-865e-1a8429a3312b/download |
| id | rum_ea0bc000cecd59f72eadde0472ebaa1f |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/65395 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/65395 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Azevedo, Maria Manuel Pina-Vaz, Cidália Baltazar, Fátima |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMultidisciplinary Digital Publishing InstituteporCancer is one of the most aggressive and deadly diseases in the world, representing the second leading cause of death. It is a multifactorial disease, in which genetic alterations play a key role, but several environmental factors also contribute to its development and progression. Infections induced by certain viruses, bacteria, fungi and parasites constitute risk factors for cancer, being chronic infection associated to the development of certain types of cancer. On the other hand, susceptibility to infectious diseases is higher in cancer patients. The state of the host immune system plays a crucial role in the susceptibility to both infection and cancer. Importantly, immunosuppressive cancer treatments increase the risk of infection, by decreasing the host defenses. Furthermore, alterations in the host microbiota is also a key factor in the susceptibility to develop cancer. More recently, the identification of a tumor microbiota, in which bacteria establish a symbiotic relationship with cancer cells, opened a new area of research. There is evidence demonstrating that the interaction between bacteria and cancer cells can modulate the anticancer drug response and toxicity. The present review focuses on the interaction between microbes and cancer, specifically aiming to: (1) review the main infectious agents associated with development of cancer and the role of microbiota in cancer susceptibility; (2) highlight the higher vulnerability of cancer patients to acquire infectious diseases; (3) document the relationship between cancer cells and tissue microbiota; (4) describe the role of intratumoral bacteria in the response and toxicity to cancer therapy.application/pdfporMicrobes and cancer: friends or faux?Azevedo, Maria ManuelPina-Vaz, CidáliaBaltazar, FátimaHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1661-6596DOIIsPartOf10.3390/ijms210931152020-05-18T09:33:05Z2020-04-282020-05-14T13:55:59Z2020-04-28T00:00:00ZHandlehttps://hdl.handle.net/1822/65395http://purl.org/coar/access_right/c_abf2open accesscancerinfectionmicrobiomecancer dysbiosistumor microbiomecancer therapy response1883261 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020-04-28http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/1b7a0284-9205-4da4-865e-1a8429a3312b/download |
| spellingShingle | Microbes and cancer: friends or faux? Azevedo, Maria Manuel cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| status | SINGLETON |
| subject.fl_str_mv | cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| title | Microbes and cancer: friends or faux? |
| title_full | Microbes and cancer: friends or faux? |
| title_fullStr | Microbes and cancer: friends or faux? |
| title_full_unstemmed | Microbes and cancer: friends or faux? |
| title_short | Microbes and cancer: friends or faux? |
| title_sort | Microbes and cancer: friends or faux? |
| topic | cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| topic_facet | cancer infection microbiome cancer dysbiosis tumor microbiome cancer therapy response |
| url | https://hdl.handle.net/1822/65395 |
| visible | 1 |