Bibliographic Details
| Summary: | The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERalpha, both encoding for transcription factors with a potential involvement in the ERalpha-mediated action in breast cancer. The purpose of this study was to explore if the expression of FOXA1 and GATA-3 may provide an opportunity to stratify subsets of patients that could have better outcome, among the ERalpha-negative/poor prognosis breast cancer group. |
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| Main Authors: | Albergaria, André |
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| Other Authors: | Paredes, Joana; Sousa, Bárbara; Milanezi, Maria Fernanda Grillo; Carneiro, Vítor; Bastos, Joana; Costa, Sandra; Vieira, Daniella; Lopes, Nair; Lam, Eric W.; Lunet, Nuno; Schmitt, Fernando |
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| Subject: | Adult Aged Aged, 80 and over Disease-Free Survival Female GATA3 Transcription Factor Hepatocyte Nuclear Factor 3-alpha Humans Immunohistochemistry Middle Aged Prognosis Proportional Hazards Models Receptors, Estrogen Treatment Outcome Gene Expression Regulation, Neoplastic Ciências Médicas::Medicina Básica |
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| Year: | 2009 |
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| Country: | Portugal |
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| Document type: | article |
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| Access type: | open access |
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| Associated institution: | Universidade do Minho |
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| Language: | English |
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| Origin: | RepositóriUM - Universidade do Minho |
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