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The ACE Project: a synopsis of in vivo studies to predict estrogenic mixture effects in freshwater and marine fish

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Resumo:This work is part of the ACE project (ACE, EVK1-CT-2001-100) which aim is to investigate multi-component mixtures of estrogenic compounds in aquatic ecosystems. Here we present a synopsis of in vivo data related with the joint estrogenic action of five estrogenic compounds (17ß-estradiol, ethynylestradiol, nonylphenol, octylphenol and bisphenol-A) on vitellogenesis in fathead minnow (Pimephales promelas) and sea bass (Dicentrarchus labrax). The studies were conducted with freshwater adult males and marine juveniles under flow through exposure conditions for two weeks. In the first step, fish were exposed to the five compounds individually in order to generate concentration- response curves. Therefore mixture effects were predicted on the basis of the potency of each compound by using the model of concentration addition (CA). Finally, the compounds were tested as a mixture at equipotent concentrations, and the observed mixture effects were compared to the predictions. The mixture studies showed an good agreement between observed and predicted effects and provided evidence that CA can be used as a predictive tool for the effect assessment of mixtures of (xeno)estrogens in freshwater or marine ecosystems. The differences/limitations of running in vivo mixture studies with freshwater and marine species will be discussed.
Autores principais:Correia, Ana D.
Outros Autores:Freitas, S.; Rodrigues, P.; Brian, Jayne; Harris, C.; Scholze, M.; Booij, P.; Lamoree, M. H.; Jonkers, N.; Pojana, G.; Marcomini, A.; Sumpter, J.; Henriques, M. A. Reis
Assunto:Estrogenic chemicals Mixture effects Prediction Fathead minnow Sea bass
Ano:2005
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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