Publicação
Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage
| Resumo: | Long-term exposure to dietary xenobiotics can induce oxidative stress in the gastrointestinal tract, possibly causing DNA damage and contributing to the initiation of carcinogenesis. Halophytes are exposed to constant abiotic stresses, which are believed to promote the accumulation of antioxidant metabolites like polyphenols. The aim of this study was to evaluate the antioxidant and antigenotoxic properties of the ethanol extract of the aerial part of the halophyte Polygonum maritimum L. (PME), which can represent a dietary source of bioactive compounds with potential to attenuate oxidative stress-related damage. The PME exhibited a high antioxidant potential, revealed by the in vitro capacity to scavenge the free radical DPPH (IC50 = 2.29 ± 0.10 μg/mL) and the improved viability of the yeast Saccharomyces cerevisiae under oxidative stress (p < 0.001, 10 min). An antigenotoxic effect of PME against H2O2-induced oxidative stress was found in S. cerevisiae (p < 0.05) with the dominant deletion assay. In vitro colorimetric assays and LC-DAD-ESI/MSn analysis showed that PME is a polyphenol-rich extract composed of catechin, (epi)catechin dimer and trimers, quercetin and myricetin glycosides. Hence, P. maritimum is a source of antioxidant and antigenotoxic metabolites for application in industries that develop products to provide health benefits. |
|---|---|
| Autores principais: | Oliveira, Daniela |
| Outros Autores: | Dias, Maria Inês; Barros, Lillian; Custódio, Luísa; Oliveira, Rui Pedro Soares de |
| Assunto: | Ciências Naturais::Ciências Biológicas |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867439013599641600 |
|---|---|
| author | Oliveira, Daniela |
| author2 | Dias, Maria Inês Barros, Lillian Custódio, Luísa Oliveira, Rui Pedro Soares de |
| author2_role | author author author author |
| author_facet | Oliveira, Daniela Dias, Maria Inês Barros, Lillian Custódio, Luísa Oliveira, Rui Pedro Soares de |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Oliveira, Daniela\"},{\"Person.name\":\"Dias, Maria Inês\"},{\"Person.name\":\"Barros, Lillian\"},{\"Person.name\":\"Custódio, Luísa\"},{\"Person.name\":\"Oliveira, Rui Pedro Soares de\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Oliveira, Daniela Dias, Maria Inês Barros, Lillian Custódio, Luísa Oliveira, Rui Pedro Soares de |
| datacite.date.Accepted.fl_str_mv | 2023-03-06T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-03-29T14:53:04Z |
| datacite.date.embargoed.fl_str_mv | 2024-03-29T14:53:04Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Ciências Naturais::Ciências Biológicas |
| datacite.titles.title.fl_str_mv | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Oliveira, Daniela Dias, Maria Inês Barros, Lillian Custódio, Luísa Oliveira, Rui Pedro Soares de |
| dc.date.Accepted.fl_str_mv | 2023-03-06T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-03-29T14:53:04Z |
| dc.date.embargoed.fl_str_mv | 2024-03-29T14:53:04Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/90300 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | Ciências Naturais::Ciências Biológicas |
| dc.title.fl_str_mv | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Long-term exposure to dietary xenobiotics can induce oxidative stress in the gastrointestinal tract, possibly causing DNA damage and contributing to the initiation of carcinogenesis. Halophytes are exposed to constant abiotic stresses, which are believed to promote the accumulation of antioxidant metabolites like polyphenols. The aim of this study was to evaluate the antioxidant and antigenotoxic properties of the ethanol extract of the aerial part of the halophyte Polygonum maritimum L. (PME), which can represent a dietary source of bioactive compounds with potential to attenuate oxidative stress-related damage. The PME exhibited a high antioxidant potential, revealed by the in vitro capacity to scavenge the free radical DPPH (IC50 = 2.29 ± 0.10 μg/mL) and the improved viability of the yeast Saccharomyces cerevisiae under oxidative stress (p < 0.001, 10 min). An antigenotoxic effect of PME against H2O2-induced oxidative stress was found in S. cerevisiae (p < 0.05) with the dominant deletion assay. In vitro colorimetric assays and LC-DAD-ESI/MSn analysis showed that PME is a polyphenol-rich extract composed of catechin, (epi)catechin dimer and trimers, quercetin and myricetin glycosides. Hence, P. maritimum is a source of antioxidant and antigenotoxic metabolites for application in industries that develop products to provide health benefits. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/62390c78-f892-41a2-8b89-b935703dcfbc/download |
| id | rum_ebbf42998dfdee3b5c716dac3ff93d45 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/90300 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/90300 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Oliveira, Daniela Dias, Maria Inês Barros, Lillian Custódio, Luísa Oliveira, Rui Pedro Soares de |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Springer Nature |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engSpringer NatureporLong-term exposure to dietary xenobiotics can induce oxidative stress in the gastrointestinal tract, possibly causing DNA damage and contributing to the initiation of carcinogenesis. Halophytes are exposed to constant abiotic stresses, which are believed to promote the accumulation of antioxidant metabolites like polyphenols. The aim of this study was to evaluate the antioxidant and antigenotoxic properties of the ethanol extract of the aerial part of the halophyte Polygonum maritimum L. (PME), which can represent a dietary source of bioactive compounds with potential to attenuate oxidative stress-related damage. The PME exhibited a high antioxidant potential, revealed by the in vitro capacity to scavenge the free radical DPPH (IC50 = 2.29 ± 0.10 μg/mL) and the improved viability of the yeast Saccharomyces cerevisiae under oxidative stress (p < 0.001, 10 min). An antigenotoxic effect of PME against H2O2-induced oxidative stress was found in S. cerevisiae (p < 0.05) with the dominant deletion assay. In vitro colorimetric assays and LC-DAD-ESI/MSn analysis showed that PME is a polyphenol-rich extract composed of catechin, (epi)catechin dimer and trimers, quercetin and myricetin glycosides. Hence, P. maritimum is a source of antioxidant and antigenotoxic metabolites for application in industries that develop products to provide health benefits.application/pdfporAntigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damageOliveira, DanielaDias, Maria InêsBarros, LillianCustódio, LuísaOliveira, Rui Pedro Soares deHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONOliveira, D., Dias, M. I., Barros, L., Custódio, L., & Oliveira, R. (2023, March 6). Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage. Scientific Reports. Springer Science and Business Media LLC. http://doi.org/10.1038/s41598-022-20402-5PMID36878934DOIIsPartOf10.1038/s41598-022-20402-52024-03-29T14:53:04Z2023-03-062023-03-06T00:00:00ZHandlehttps://hdl.handle.net/1822/90300http://purl.org/coar/access_right/c_abf2open accesshttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Ciências Naturais::Ciências Biológicas1240644 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2023-03-06http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/62390c78-f892-41a2-8b89-b935703dcfbc/download |
| spellingShingle | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage Oliveira, Daniela Ciências Naturais::Ciências Biológicas |
| status | SINGLETON |
| subject.other.fl_str_mv | Ciências Naturais::Ciências Biológicas |
| title | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| title_full | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| title_fullStr | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| title_full_unstemmed | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| title_short | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| title_sort | Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage |
| topic | Ciências Naturais::Ciências Biológicas |
| topic_facet | Ciências Naturais::Ciências Biológicas |
| url | https://hdl.handle.net/1822/90300 |
| visible | 1 |